2. Gene
  3. APOC4 - apolipoprotein C4 Gene

APOC4 - apolipoprotein C4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：载脂蛋白 C4

种属: Homo sapiens

同用名: APO-CIV; APOC-IV

基因 ID: 346 | 基因类型: protein coding

关于 APOC4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,942,237-44,945,496 (from NCBI)

This gene has 2 transcripts (splice variants) and 77 orthologues. Restricted expression toward liver (RPKM 124.3).

功能概要

该基因编码属于载脂蛋白基因家族的脂质结合蛋白。该蛋白质被认为在脂质代谢中发挥作用。该基因的多态性可能影响循环脂质水平，并可能与冠状动脉疾病风险相关。该基因与其他相关载脂蛋白基因一起存在于 19 号染色体上的簇中。该基因与邻近的下游载脂蛋白 C-II (APOC2) 基因之间存在自然发生的通读转录。[RefSeq 提供，2011 年 3 月]

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011]

APOC4 基因产物(1)

mRNA Protein Name
NM_001646.3 NP_001637.1 apolipoprotein C-IV precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of sequestering of triglyceride IMP
IMP: 通过突变表型推断
18809223 GOA
involved in triglyceride homeostasis IMP
IMP: 通过突变表型推断
8827523 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of high-density lipoprotein particle IDA
IDA: 通过直接分析推断
12700345 GOA
part of very-low-density lipoprotein particle IDA
IDA: 通过直接分析推断
12700345 GOA
part of very-low-density lipoprotein particle IMP
IMP: 通过突变表型推断
8827523 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

APOC4 蛋白结构

APOC4

APOC4: Apolipoprotein C4 (27 - 125)

  • 0
  • 100
  • 127 a.a.
蛋白主名 其他名称

apolipoprotein C-IV

APOC4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra APOC4 P55056 SYT16 Homo sapiens Q17RD7
Validated Y2H
32296183
Intra APOC4 P55056 SNAP47 Homo sapiens Q5SQN1
Validated Y2H
32296183
Intra APOC4 P55056 MAIP1 Homo sapiens Q8WWC4
Validated Y2H
32296183
Intra APOC4 P55056 MICOS13 Homo sapiens Q5XKP0
Validated Y2H
32296183
Intra APOC4 P55056 GSDMA Homo sapiens Q96QA5
Validated Y2H
32296183
Intra APOC4 P55056 RSAD2 Homo sapiens Q8WXG1
Validated Y2H
32296183
Intra APOC4 P55056 MICOS10 Homo sapiens Q5TGZ0
Validated Y2H
32296183
Intra APOC4 P55056 LETMD1 Homo sapiens Q6P1Q0
Validated Y2H
32296183
Intra APOC4 P55056 TPRG1 Homo sapiens Q6ZUI0
Validated Y2H
32296183
Intra APOC4 P55056 PORCN Homo sapiens Q9H237-2
Validated Y2H
32296183
Intra APOC4 P55056 APOL2 Homo sapiens Q9BQE5
Validated Y2H
32296183
Intra APOC4 P55056 DIABLO Homo sapiens Q9NR28
Validated Y2H
32296183
Intra APOC4 P55056 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra APOC4 P55056 BCL2L2 Homo sapiens Q92843
Validated Y2H
32296183
Intra APOC4 P55056 SENP2 Homo sapiens Q9HC62
Validated Y2H
32296183
Intra APOC4 P55056 NFU1 Homo sapiens Q9UMS0
Validated Y2H
32296183
Intra APOC4 P55056 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra APOC4 P55056 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra APOC4 P55056 TBC1D20 Homo sapiens Q96BZ9
Validated Y2H
32296183
Intra APOC4 P55056 TBC1D20 Homo sapiens Q96BZ9
Y2H Array
32296183
Intra APOC4 P55056 GAD2 Homo sapiens Q05329
Validated Y2H
32296183
Intra APOC4 P55056 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hyperlipoproteinemia, Type Iv

Hyperlipoproteinemia Type Iv

Carbohydrate-Inducible Hyperlipemia

Endogenous Hyperlipidaemia

Familial Hypertriglyceridemia

Fredrickson Type Iv Hyperlipoproteinemia

Fredrickson Type Iv Lipidaemia

Fredrickson Type Iv Lipidemia

Vldl Hyperlipoproteinemia

Hyperlipoproteinemia Type 4

Carbohydrate Inducible Hyperlipemia

Familial Type Iv Hyperlipoproteinemia

Familial Hyperlipoproteinemia Type Iv
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00847 APOC4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus APOC4 MGD MGI:87878
Felis catus APOC4 VGNC VGNC:103060
Canis familiaris APOC4 VGNC VGNC:53523
Bos taurus APOC4 VGNC VGNC:52177
Macaca mulatta APOC4 VGNC VGNC:109594
Rattus norvegicus APOC4 RGD RGD:70959
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