1. Gene
  2. RSAD2 - radical S-adenosyl methionine domain containing 2 Gene

RSAD2 - radical S-adenosyl methionine domain containing 2 Gene

中文名称:含自由基 S-腺苷甲硫氨酸结构域 2

种属: Homo sapiens

同用名: cig5; vig1; cig33

基因 ID: 91543 | 基因类型: protein coding

关于 RSAD2

Cytogenetic location: 2p25.2 Genomic coordinates (GRCh38): 2:6,865,885-6,898,239 (from NCBI)

This gene has 9 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in spleen (RPKM 6.0), lung (RPKM 5.3) and 24 other tissues.

功能概要

该基因编码的蛋白质是一种干扰素诱导型抗病毒蛋白,属于 S-腺苷-L-甲硫氨酸 (SAM) 酶超家族。该蛋白在细胞抗病毒反应和先天免疫信号中发挥作用。抗病毒作用源于病毒 RNA 复制的抑制、分泌途径的干扰、与病毒蛋白的结合以及细胞脂质代谢的失调。已发现该蛋白质可抑制 DNA 和 RNA 病毒,包括流感病毒、人类免疫缺陷病毒 (HIV-1) 和寨卡病毒。[RefSeq 提供,2020 年 9 月]

The protein encoded by this gene is an interferon-inducible Antiviral protein that belongs to the S-adenosyl-L-methionine (SAM) superfamily of Enzymes. The protein plays a role in cellular Antiviral response and innate immune signaling. Antiviral effects result from inhibition of viral RNA replication, interference in the secretory pathway, binding to Viral Proteins and dysregulation of cellular lipid metabolism. The protein has been found to inhibit both DNA and RNA viruses, including Influenza Virus, human immunodeficiency virus (HIV-1) and Zika virus. [provided by RefSeq, Sep 2020]

RSAD2 基因产物(2)

mRNA Protein Name
NM_001410702.1 NP_001397631.1 radical S-adenosyl methionine domain-containing protein 2 isoform 2
NM_080657.5 NP_542388.2 radical S-adenosyl methionine domain-containing protein 2 isoform 1

RSAD2 蛋白结构

Fer4_12

Fer4_12: 4Fe-4S single cluster domain (78 - 176)

Radical_SAM

Radical_SAM: Radical SAM superfamily (79 - 209)

  • 0
  • 100
  • 200
  • 300
  • 361 a.a.
蛋白主名 其他名称

radical S-adenosyl methionine domain-containing protein 2

cytomegalovirus-induced gene 5 protein

RSAD2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RSAD2 Q8WXG1 VAPA Homo sapiens Q9P0L0
Anti Tag CoIP
21957124
Intra RSAD2 Q8WXG1 VAPA Homo sapiens Q9P0L0
Confocal
22045669
Intra RSAD2 Q8WXG1 VAPA Homo sapiens Q9P0L0
FRET
22045669
Intra RSAD2 Q8WXG1 APOC1 Homo sapiens P02654
Y2H Array
32296183
Intra RSAD2 Q8WXG1 APOC1 Homo sapiens P02654
Y2H Prey Pooling
32296183
Intra RSAD2 Q8WXG1 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
Intra RSAD2 Q8WXG1 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
Intra RSAD2 Q8WXG1 APOC4 Homo sapiens P55056
Y2H Prey Pooling
32296183
Intra RSAD2 Q8WXG1 APOC4 Homo sapiens P55056
Y2H Array
32296183
Intra RSAD2 Q8WXG1 CIAO1 Homo sapiens O76071
Anti Bait CoIP
24245804
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Yellow Fever

Urban Yellow Fever

Jungle Yellow Fever

Sylvatic Yellow Fever

Yf

Yellow Fever, Sylvan

Bronze John

Yellow Jack

Yf- [Yellow Fever]

Febris Flava

Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever

Stomatitis
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Japanese Encephalitis

Japanese B Encephalitis

Je

Encephalitis Japanese

Encephalitis, Japanese

Russian Autumnal Encephalitis

Je - [Japanese Encephalitis]

Japanese Encephalitis Virus Disease

Jbe - [Japanese B Encephalitis}

B Type Encephalitis

Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis

West Nile Virus

West Nile Virus, Susceptibility To

Wnv

Wnv, Susceptibility To

West Nile Viral Infection

Encephalitis, West Nile Fever

West Nile Fever

Dengue Virus

Dengue Virus, Susceptibility To

Dengue Fever, Protection Against

Dengue Fever

Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome

Ophthalmoacromelic Syndrome

OAS

MLA

Anophthalmia-Syndactyly

Anophthalmia-Syndactyly Syndrome

Anophthalmos With Limb Anomalies

Anophthalmia Waardenburg Syndrome

Anophthalmos-Syndactyly

Ophthalmo-Acromelic Syndrome

Anophthalmia-Waardenburg Syndrome

Anophthalmos-Limb Anomalies Syndrome

Syndactyly-Anophthalmos Syndrome

Microphthalmia, With Limb Anomalies

Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus RSAD2 MGD MGI:1929628
Rattus norvegicus RSAD2 RGD RGD:620495
Bos taurus RSAD2 VGNC VGNC:34176
Macaca mulatta RSAD2 VGNC VGNC:77143
Canis familiaris RSAD2 VGNC VGNC:45770
Felis catus RSAD2 VGNC VGNC:81214