1. Gene
  2. CIAO1 - cytosolic iron-sulfur assembly component 1 Gene

CIAO1 - cytosolic iron-sulfur assembly component 1 Gene

中文名称:胞质铁硫组装组分 1

种属: Homo sapiens

同用名: CIA1; WDR39

基因 ID: 9391 | 基因类型: protein coding

关于 CIAO1

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,266,225-96,274,173 (from NCBI)

This gene has 4 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in adrenal (RPKM 18.1), kidney (RPKM 17.3) and 25 other tissues.

功能概要

通过铁硫簇转移参与铁硫簇组装和蛋白质成熟。位于细胞质中。 CIA 复合体和 MMXD 复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Located in cytoplasm. Part of CIA complex and MMXD complex. [provided by Alliance of Genome Resources, Apr 2022]

CIAO1 基因产物(1)

mRNA Protein Name
NM_004804.3 NP_004795.1 probable cytosolic iron-sulfur protein assembly protein CIAO1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in iron-sulfur cluster assembly IGI
IGI: 通过遗传相互作用推断
17937914 GOA
involved in iron-sulfur cluster assembly IMP
IMP: 通过突变表型推断
23891004 GOA
involved in protein maturation by iron-sulfur cluster transfer IMP
IMP: 通过突变表型推断
23891004 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MMXD complex IDA
IDA: 通过直接分析推断
20797633 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
23585563 GOA
part of cytosolic [4Fe-4S] assembly targeting complex IDA
IDA: 通过直接分析推断
22678361 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CIAO1 蛋白结构

WD40

WD40: WD domain, G-beta repeat (17 - 43)

WD40

WD40: WD domain, G-beta repeat (50 - 89)

WD40

WD40: WD domain, G-beta repeat (96 - 133)

WD40

WD40: WD domain, G-beta repeat (141 - 177)

WD40

WD40: WD domain, G-beta repeat (184 - 221)

WD40

WD40: WD domain, G-beta repeat (241 - 279)

WD40

WD40: WD domain, G-beta repeat (299 - 332)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
蛋白主名 其他名称

probable cytosolic iron-sulfur protein assembly protein CIAO1

WD repeat domain 39

CIAO1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CIAO1 O76071 MMS19 Homo sapiens Q96T76-8
Y2H Array
25416956
Intra CIAO1 O76071 MMS19 Homo sapiens Q96T76-8
Y2H Prey Pooling
25416956
Intra CIAO1 O76071 MMS19 Homo sapiens Q96T76
Anti Bait CoIP
17353931
Intra CIAO1 O76071 MMS19 Homo sapiens Q96T76
Anti Tag CoIP
28178521
Intra CIAO1 O76071 MMS19 Homo sapiens Q96T76
TAP
24981860
Intra CIAO1 O76071 SLC4A7 Homo sapiens Q9Y6M7
Y2H Prey Pooling
32296183
Intra CIAO1 O76071 SLC4A7 Homo sapiens Q9Y6M7
Validated Y2H
32296183
Intra CIAO1 O76071 SLC4A7 Homo sapiens Q9Y6M7
Y2H Array
32296183
Intra CIAO1 O76071 SHISA6 Homo sapiens Q6ZSJ9
Y2H Array
32296183
Intra CIAO1 O76071 SHISA6 Homo sapiens Q6ZSJ9
Y2H Prey Pooling
32296183
Intra CIAO1 O76071 SHISA6 Homo sapiens Q6ZSJ9
Validated Y2H
32296183
Intra CIAO1 O76071 ANKRD55 Homo sapiens Q3KP44
Validated Y2H
32296183
Intra CIAO1 O76071 ANKRD55 Homo sapiens Q3KP44
Y2H Prey Pooling
32296183
Intra CIAO1 O76071 ANKRD55 Homo sapiens Q3KP44
Y2H Array
32296183
Intra CIAO1 O76071 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra CIAO1 O76071 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra CIAO1 O76071 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra CIAO1 O76071 C19orf2 Homo sapiens Q6NX55
Y2H Array
32296183
Intra CIAO1 O76071 C19orf2 Homo sapiens Q6NX55
Y2H Prey Pooling
32296183
Intra CIAO1 O76071 C19orf2 Homo sapiens Q6NX55
Validated Y2H
32296183
Intra CIAO1 O76071 HAUS3 Homo sapiens Q68CZ6
Y2H Array
32296183
Intra CIAO1 O76071 HAUS3 Homo sapiens Q68CZ6
Y2H Prey Pooling
32296183
Intra CIAO1 O76071 HAUS3 Homo sapiens Q68CZ6
Validated Y2H
32296183
Intra CIAO1 O76071 MEOX1 Homo sapiens P50221
Y2H Array
25416956
Intra CIAO1 O76071 TOP3B Homo sapiens O95985
Validated Y2H
32296183
Intra CIAO1 O76071 TCP10L Homo sapiens Q8TDR4
Validated Y2H
32296183
Intra CIAO1 O76071 TCP10L Homo sapiens Q8TDR4
Y2H Prey Pooling
32296183
Intra CIAO1 O76071 TCP10L Homo sapiens Q8TDR4
Y2H Array
32296183
Intra CIAO1 O76071 ERCC2 Homo sapiens P18074
Anti Tag CoIP
23585563
Intra CIAO1 O76071 RGS2 Homo sapiens P41220
Y2H Prey Pooling
32296183
Intra CIAO1 O76071 RGS2 Homo sapiens P41220
Validated Y2H
32296183
Intra CIAO1 O76071 RGS2 Homo sapiens P41220
Y2H Array
32296183
Intra CIAO1 O76071 CIAO2B Homo sapiens Q9Y3D0
Y2H Array
32296183
Intra CIAO1 O76071 CIAO2B Homo sapiens Q9Y3D0
Anti Tag CoIP
28178521
Intra CIAO1 O76071 CIAO2B Homo sapiens Q9Y3D0
Y2H Prey Pooling
32296183
Intra CIAO1 O76071 CIAO2B Homo sapiens Q9Y3D0
TAP
24981860
Intra CIAO1 O76071 CIAO2B Homo sapiens Q9Y3D0
Y2H Pooling
16189514
Intra CIAO1 O76071 CIAO2B Homo sapiens Q9Y3D0
Validated Y2H
32296183
Intra CIAO1 O76071 CIAO2B Homo sapiens Q9Y3D0
Y2H Array
25416956
Intra CIAO1 O76071 SF1 Homo sapiens Q15637
Y2H Prey Pooling
25416956
Intra CIAO1 O76071 SF1 Homo sapiens Q15637
Validated Y2H
25416956
Intra CIAO1 O76071 CIAO2A Homo sapiens Q9H5X1
Y2H Prey Pooling
25416956
Intra CIAO1 O76071 CIAO2A Homo sapiens Q9H5X1
Y2H Prey Pooling
32296183
Intra CIAO1 O76071 CIAO2A Homo sapiens Q9H5X1
Validated Y2H
32296183
Intra CIAO1 O76071 CIAO2A Homo sapiens Q9H5X1
Y2H Array
25416956
Intra CIAO1 O76071 CIAO2A Homo sapiens Q9H5X1
Y2H Array
32296183
Intra CIAO1 O76071 CIAO2A Homo sapiens Q9H5X1
TAP
24981860
Intra CIAO1 O76071 CIAO2A Homo sapiens Q9H5X1
Y2H Pooling
16189514
Intra CIAO1 O76071 CIAO2A Homo sapiens Q9H5X1
GMS
32222833
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 6

Mitochondrial Dna Deletion Syndrome With Progressive Myopathy

PEOA6

Autosomal Dominant Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions 6

Dna2-Related Mitochondrial Dna Deletion Syndrome

Mitochondrial Dna Deletion Syndrome With Limb-Girdle Weakness

Mtdna Deletion Syndrome With Limb-Girdle Weakness

Mtdna Deletion Syndrome With Progressive Myopathy

Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 6

Progressive External Ophthalmoplegia, Autosomal Dominant 6

Autosomal Dominant Progressive External Ophthalmoplegia 6

Progressive External Ophthalmoplegia Autosomal Dominant 6

Ophthalmoplegia, External, Progressive, With Mitochondrial Dna Deletions, Autosomal Dominant, Type 6

Xeroderma Pigmentosum, Complementation Group D

Xeroderma Pigmentosum, Group D

Xpdc

Xeroderma Pigmentosum Iv

XPD

Xeroderma Pigmentosum Group D

Xeroderma Pigmentosum Viii

Xp Group D

Xp Group H

Xp4

Xp8

Xph

Xp, Group D

Xp4 Xeroderma Pigmentosum Viii, Formerly

Xp8, Formerly

Xp, Group H, Formerly

Xph, Formerly

Xeroderma Pigmentosum Complementation Group D

XP-D

Xp-D/Cs

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CIAO1 MGD MGI:1346998
Canis familiaris CIAO1 VGNC VGNC:39263
Felis catus CIAO1 VGNC VGNC:80065
Rattus norvegicus CIAO1 RGD RGD:1307285
Macaca mulatta CIAO1 VGNC VGNC:70950
Bos taurus CIAO1 VGNC VGNC:27356
Others CIAO1 NCBI