2. Gene
  3. SHISA6 - shisa family member 6 Gene

SHISA6 - shisa family member 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：shisa 家族成员 6

种属: Homo sapiens

基因 ID: 388336 | 基因类型: protein coding

关于 SHISA6

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:11,241,213-11,564,063 (from NCBI)

This gene has 4 transcripts (splice variants), 281 orthologues and 3 paralogues. Biased expression in brain (RPKM 3.7), endometrium (RPKM 2.0) and 9 other tissues.

功能概要

预测启用离子型谷氨酸受体结合活性。预计参与多个过程，包括兴奋性化学突触传递；调节短期神经元突触可塑性；和信号转导的调节。预计位于不对称、谷氨酸能、兴奋性突触中。预计是 AMPA 谷氨酸受体复合物的一部分。预计在谷氨酸能突触中活跃；突触后密度；和突触膜。预计是突触后密度膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including excitatory chemical synaptic transmission; regulation of short-term neuronal synaptic plasticity; and regulation of signal transduction. Predicted to be located in asymmetric, glutamatergic, excitatory synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in glutamatergic synapse; postsynaptic density; and synaptic membrane. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022]

SHISA6 基因产物(3)

mRNA Protein Name
NM_001173461.1 NP_001166932.1 protein shisa-6 isoform 2 precursor
NM_001173462.2 NP_001166933.1 protein shisa-6 isoform 3 precursor
NM_207386.4 NP_997269.2 protein shisa-6 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SHISA6 蛋白结构

Shisa

Shisa: Wnt and FGF inhibitory regulator (90 - 271)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500 a.a.
蛋白主名 其他名称

protein shisa-6

protein shisa-6 homolog

SHISA6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SHISA6 Q6ZSJ9 CTBP2 Homo sapiens P56545-3
Y2H Array
32296183
Intra SHISA6 Q6ZSJ9 CTBP2 Homo sapiens P56545-3
Y2H Prey Pooling
32296183
Intra SHISA6 Q6ZSJ9 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra SHISA6 Q6ZSJ9 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra SHISA6 Q6ZSJ9 NEDD4 Homo sapiens P46934-3
Y2H Prey Pooling
32296183
Intra SHISA6 Q6ZSJ9 NEDD4 Homo sapiens P46934-3
Y2H Array
32296183
Intra SHISA6 Q6ZSJ9 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
Intra SHISA6 Q6ZSJ9 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
Intra SHISA6 Q6ZSJ9 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra SHISA6 Q6ZSJ9 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra SHISA6 Q6ZSJ9 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
Intra SHISA6 Q6ZSJ9 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra SHISA6 Q6ZSJ9 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra SHISA6 Q6ZSJ9 EXOSC5 Homo sapiens Q9NQT4
Validated Y2H
32296183
Intra SHISA6 Q6ZSJ9 FBLIM1 Homo sapiens Q8WUP2
Validated Y2H
32296183
Intra SHISA6 Q6ZSJ9 FBLIM1 Homo sapiens Q8WUP2
Y2H Array
32296183
Intra SHISA6 Q6ZSJ9 FBLIM1 Homo sapiens Q8WUP2
Y2H Prey Pooling
32296183
Intra SHISA6 Q6ZSJ9 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra SHISA6 Q6ZSJ9 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra SHISA6 Q6ZSJ9 TSSK3 Homo sapiens Q96PN8
Validated Y2H
32296183
Intra SHISA6 Q6ZSJ9 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra SHISA6 Q6ZSJ9 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra SHISA6 Q6ZSJ9 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra SHISA6 Q6ZSJ9 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra SHISA6 Q6ZSJ9 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra SHISA6 Q6ZSJ9 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra SHISA6 Q6ZSJ9 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra SHISA6 Q6ZSJ9 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra SHISA6 Q6ZSJ9 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra SHISA6 Q6ZSJ9 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra SHISA6 Q6ZSJ9 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra SHISA6 Q6ZSJ9 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra SHISA6 Q6ZSJ9 ARMC7 Homo sapiens Q9H6L4
Validated Y2H
32296183
Intra SHISA6 Q6ZSJ9 KIF9 Homo sapiens Q9HAQ2
Validated Y2H
32296183
Intra SHISA6 Q6ZSJ9 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra SHISA6 Q6ZSJ9 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra SHISA6 Q6ZSJ9 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra SHISA6 Q6ZSJ9 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Scleral Staphyloma

Scleral Ectasia

Staphyloma Of Sclera
Degenerative Myopia

Pathological Myopia

Myopia, Degenerative

Degenerative Progressive High Myopia

Progressive High Myopia

Progressive High Myopia
Griscelli Syndrome, Type 3

Griscelli Syndrome Type 3

GS3

Griscelli-Prunieras Syndrome Type 3

Hypomelanosis With No Immunologic Or Neurologic Manifestations

Griscelli Syndrome 3
Myopia

Near-Sightedness

Short-Sightedness

Nearsightedness

Nearsighted

Near Vision

Close Sighted

Myopic

Short-Sighted

Near Sighted
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked

Christ-Siemens-Touraine Syndrome

XHED

Ectodermal Dysplasia 1

Xlhed

Ed1

Cst Syndrome

Ectodermal Dysplasia 1, Hypohidrotic/Hair/Tooth Type, X-Linked

Ectd1

Ectodermal Dysplasia, Anhidrotic, X-Linked

Eda

Eda1

Hed1

Ectodermal Dysplasia 1, Anhidrotic

X-Linked Anhidrotic Ectodermal Dysplasia

X-Linked Hypohidrotic Ectodermal Dysplasia

Hypohidrotic X-Linked Ectodermal Dysplasia

Ectodermal Dysplasia, Hypohidrotic, 1

Hypohidrotic Ectodermal Dysplasia, X-Linked

Anhidrotic Ectodermal Dysplasia X-Linked

Hypohidrotic Ectodermal Dysplasia X-Linked

Ectodermal Dysplasia 1 Hypohidrotic/Hair/Tooth Type X-Linked

Ectodermal Dysplasia Anhidrotic
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12869 SHISA6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SHISA6 VGNC VGNC:99449
Macaca mulatta SHISA6 VGNC VGNC:104650
Rattus norvegicus SHISA6 RGD RGD:1564618
Canis familiaris SHISA6 VGNC VGNC:46148
Mus musculus SHISA6 MGD MGI:2685725
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