RGS2 - regulator of G protein signaling 2 Gene

中文名称：G 蛋白信号调节器 2

种属: Homo sapiens

同用名: G0S8

基因 ID: 5997 | 基因类型: protein coding

关于 RGS2

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:192,809,039-192,812,275 (from NCBI)

This gene has 4 transcripts (splice variants), 242 orthologues and 23 paralogues. Broad expression in bone marrow (RPKM 211.2), adrenal (RPKM 208.4) and 20 other tissues.

功能概要

G 蛋白信号转导调节子 (RGS) 家族成员是调节分子，可作为异源三聚体 G 蛋白的 G α 亚基的 GTP 酶激活蛋白 (GAP) 。 RGS 蛋白能够使 Gi α、Go α 和 Gq α 亚型的 G 蛋白亚基失活。它们将 G 蛋白驱动为无活性的 GDP 结合形式。 G 蛋白信号调节器 2 属于该家族。该蛋白质充当骨髓分化的介质，并可能在白血病发生中发挥作用。[RefSeq 提供，2009 年 8 月]

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]

RGS2 基因产物(1)

mRNA	Protein	Name
NM_002923.4	NP_002914.1	regulator of G-protein signaling 2

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G-protein alpha-subunit binding	IPI IPI: 通过物理相互作用推断	19478087	GOA
enables GTPase activator activity	IMP IMP: 通过突变表型推断	19478087	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14608379	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	11278586	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10791963	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	11278586	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RGS2 蛋白结构

RGS

0
100
211 a.a.

蛋白主名

其他名称

regulator of G-protein signaling 2

G0 to G1 switch regulatory 8, 24kD

RGS2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RGS2	P41220	MTUS2	Homo sapiens	Q5JR59-3	Y2H Bait-Prey Pool	25910212
Intra	RGS2	P41220	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	25910212
Intra	RGS2	P41220	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	25910212
Intra	RGS2	P41220	PPP1R9A	Homo sapiens	Q9ULJ8	Pull Down	17464283
Intra	RGS2	P41220	LRRK2	Homo sapiens	Q5S007	Confocal	24794857
Intra	RGS2	P41220	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	RGS2	P41220	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Agoraphobia

Fear Of Open Spaces

Phobia Of Going Out

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-169282	RGS2–Galpha-q interaction-IN-1		/	否
HY-RS11916	RGS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	RGS2	VGNC	VGNC:45529
Macaca mulatta	RGS2	VGNC	VGNC:106484
Mus musculus	RGS2	MGD	MGI:1098271
Rattus norvegicus	RGS2	RGD	RGD:621665
Felis catus	RGS2	VGNC	VGNC:69314

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