SF1 - splicing factor 1 Gene

中文名称：剪接因子 1

种属: Homo sapiens

同用名: BBP; MBBP; ZFM1; ZNF162; D11S636; ZCCHC25

关于 SF1

功能概要

该基因编码核前 mRNA 剪接因子。编码的蛋白质特异性识别 3' 剪接位点的内含子分支点序列，以及 U2 辅助因子 (U2AF) 的大亚基，并且是剪接体组装早期阶段所必需的。它还在核前体 mRNA 保留和转录抑制中发挥作用。编码的蛋白质包含一个 N 末端 U2AF 配体基序、一个中心 hnRNP K 同源基序和 quaking 2 区域，它结合分支点序列中的一个关键分支位点腺苷、一个锌关节结构域和一个 C 末端富含脯氨酸的结构域.可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 10 月]

This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]