2. Gene
  3. KPNA1 - karyopherin subunit alpha 1 Gene

KPNA1 - karyopherin subunit alpha 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核转运蛋白亚基 alpha 1

种属: Homo sapiens

同用名: RCH2; SRP1; IPOA5; NPI-1

基因 ID: 3836 | 基因类型: protein coding

关于 KPNA1

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,421,902-122,514,939 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 10.0), testis (RPKM 7.9) and 25 other tissues.

功能概要

真核细胞中分子在细胞核和细胞质之间的运输是由核孔复合体 (NPC) 介导的，它由 60-100 种蛋白质组成。小分子 (高达 70 kD) 可以通过非选择性扩散穿过核孔，而大分子则通过活性过程运输。该基因编码的蛋白属于 importin alpha 家族，参与核蛋白导入。该蛋白与重组激活基因 1 (RAG1) 蛋白相互作用，是 RAG1 泛素连接酶的推定底物。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 11 月]

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin Ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

KPNA1 基因产物(1)

mRNA Protein Name
NM_002264.4 NP_002255.3 importin subunit alpha-5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear import signal receptor activity IDA
IDA: 通过直接分析推断
7892216 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10523667 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in NLS-bearing protein import into nucleus IDA
IDA: 通过直接分析推断
7892216 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NLS-dependent protein nuclear import complex IPI
IPI: 通过物理相互作用推断
10523667 GOA
is active in cytosol IDA
IDA: 通过直接分析推断
7892216 GOA
is active in nucleoplasm IDA
IDA: 通过直接分析推断
7892216 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KPNA1 蛋白结构

IBB

IBB: Importin beta binding domain (3 - 94)

Arm

Arm: Armadillo/beta-catenin-like repeat (115 - 156)

Arm

Arm: Armadillo/beta-catenin-like repeat (158 - 197)

Arm

Arm: Armadillo/beta-catenin-like repeat (203 - 241)

Arm

Arm: Armadillo/beta-catenin-like repeat (254 - 283)

Arm

Arm: Armadillo/beta-catenin-like repeat (286 - 324)

Arm

Arm: Armadillo/beta-catenin-like repeat (330 - 367)

Arm

Arm: Armadillo/beta-catenin-like repeat (369 - 408)

Arm

Arm: Armadillo/beta-catenin-like repeat (412 - 451)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 538 a.a.
蛋白主名 其他名称

importin subunit alpha-5

RAG cohort protein 2

KPNA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KPNA1 P52294 STAT1 Homo sapiens P42224
Anti Tag CoIP
17596301
Intra KPNA1 P52294 NUP50 Homo sapiens Q9UKX7
Y2H Prey Pooling
25416956
Intra KPNA1 P52294 NUP50 Homo sapiens Q9UKX7
Validated Y2H
25416956
Intra KPNA1 P52294 NUP50 Homo sapiens Q9UKX7
Anti Tag CoIP
26496610
Intra KPNA1 P52294 NUP50 Homo sapiens Q9UKX7
Validated Y2H
32296183
Intra KPNA1 P52294 NUP50 Homo sapiens Q9UKX7
Anti Tag CoIP
35271311
Intra KPNA1 P52294 KPNB1 Homo sapiens Q14974
Anti Tag CoIP
17596301
Intra KPNA1 P52294 KPNB1 Homo sapiens Q14974
Anti Tag CoIP
35271311
Intra KPNA1 P52294 NMNAT1 Homo sapiens Q9HAN9
Validated Y2H
32296183
Intra KPNA1 P52294 MACROD1 Homo sapiens Q9BQ69
Validated Y2H
32296183
Intra KPNA1 P52294 POLR3C Homo sapiens Q9BUI4
Validated Y2H
32296183
Intra KPNA1 P52294 POLR3C Homo sapiens Q9BUI4
Anti Tag CoIP
33961781
Intra KPNA1 P52294 CLK4 Homo sapiens Q9HAZ1
Validated Y2H
25416956
Intra KPNA1 P52294 SF1 Homo sapiens Q15637
Y2H Fragment Pooling
26420826
Intra KPNA1 P52294 ANP32B Homo sapiens Q92688
Y2H
21988832
Intra KPNA1 P52294 ANP32B Homo sapiens Q92688
Confocal
21988832
Intra KPNA1 P52294 ANP32B Homo sapiens Q92688
Validated Y2H
25416956
Intra KPNA1 P52294 ANP32B Homo sapiens Q92688
Validated Y2H
32296183
Intra KPNA1 P52294 ANP32B Homo sapiens Q92688
Anti Tag CoIP
35271311
Intra KPNA1 P52294 ANP32B Homo sapiens Q92688
Y2H Prey Pooling
25416956
Intra KPNA1 P52294 GRM1 Homo sapiens Q13255
Anti Tag CoIP
19084525
Intra KPNA1 P52294 GRM1 Homo sapiens Q13255
Anti Bait CoIP
19084525
Intra KPNA1 P52294 LMNB1 Homo sapiens P20700
Anti Tag CoIP
26496610
Cross KPNA1 P52294 PB2 Influenza A virus B4URF7
Pull Down
21994455
Cross KPNA1 P52294 PB2 Influenza A virus P31345
X-Ray Diffraction
17310249
Cross KPNA1 P52294 PB2 Influenza A virus P31345
GMS
17310249
Cross KPNA1 P52294 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Y2H Prey Pooling
18985028
Cross KPNA1 P52294 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Pull Down
18985028
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Venezuelan Equine Encephalitis

Venezuelan Equine Fever

Venezuelan Equine Encephalomyelitis

Encephalitis Venezuelan Equine

Encephalomyelitis, Venezuelan Equine

Venezuelan Encephalitis

Disorder Due To Venezuelan Equine Encephalitis Virus

Venezuelan Equine Encephalitis Virus Infection

Venezuelan Equine Encephalomyelitis Virus Disease
Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Plica Syndrome

Synovitis
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07415 KPNA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus KPNA1 RGD RGD:735064
Felis catus KPNA1 VGNC VGNC:102766
Mus musculus KPNA1 MGD MGI:103560
Bos taurus KPNA1 VGNC VGNC:30700
Macaca mulatta KPNA1 VGNC VGNC:74199
Canis familiaris KPNA1 VGNC VGNC:42500
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z