KPNA1 - karyopherin subunit alpha 1 Gene

中文名称：核转运蛋白亚基 alpha 1

种属: Homo sapiens

同用名: RCH2; SRP1; IPOA5; NPI-1

基因 ID: 3836 | 基因类型: protein coding

关于 KPNA1

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,421,902-122,514,939 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 10.0), testis (RPKM 7.9) and 25 other tissues.

功能概要

真核细胞中分子在细胞核和细胞质之间的运输是由核孔复合体 (NPC) 介导的，它由 60-100 种蛋白质组成。小分子 (高达 70 kD) 可以通过非选择性扩散穿过核孔，而大分子则通过活性过程运输。该基因编码的蛋白属于 importin alpha 家族，参与核蛋白导入。该蛋白与重组激活基因 1 (RAG1) 蛋白相互作用，是 RAG1 泛素连接酶的推定底物。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 11 月]

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin Ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

KPNA1 基因产物(1)

mRNA	Protein	Name
NM_002264.4	NP_002255.3	importin subunit alpha-5

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables nuclear import signal receptor activity	IDA IDA: 通过直接分析推断	7892216	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10523667	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in NLS-bearing protein import into nucleus	IDA IDA: 通过直接分析推断	7892216	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of NLS-dependent protein nuclear import complex	IPI IPI: 通过物理相互作用推断	10523667	GOA
is active in cytosol	IDA IDA: 通过直接分析推断	7892216	GOA
is active in nucleoplasm	IDA IDA: 通过直接分析推断	7892216	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KPNA1 蛋白结构

IBB

Arm

0
100
200
300
400
500
538 a.a.

蛋白主名

其他名称

importin subunit alpha-5

RAG cohort protein 2

KPNA1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	KPNA1	P52294	STAT1	Homo sapiens	P42224	Anti Tag CoIP	17596301
种属内	KPNA1	P52294	NUP50	Homo sapiens	Q9UKX7	Y2H Prey Pooling	25416956
种属内	KPNA1	P52294	NUP50	Homo sapiens	Q9UKX7	Validated Y2H	25416956
种属内	KPNA1	P52294	NUP50	Homo sapiens	Q9UKX7	Anti Tag CoIP	26496610
种属内	KPNA1	P52294	NUP50	Homo sapiens	Q9UKX7	Validated Y2H	32296183
种属内	KPNA1	P52294	NUP50	Homo sapiens	Q9UKX7	Anti Tag CoIP	35271311
种属内	KPNA1	P52294	KPNB1	Homo sapiens	Q14974	Anti Tag CoIP	17596301
种属内	KPNA1	P52294	KPNB1	Homo sapiens	Q14974	Anti Tag CoIP	35271311
种属内	KPNA1	P52294	NMNAT1	Homo sapiens	Q9HAN9	Validated Y2H	32296183
种属内	KPNA1	P52294	MACROD1	Homo sapiens	Q9BQ69	Validated Y2H	32296183
种属内	KPNA1	P52294	POLR3C	Homo sapiens	Q9BUI4	Validated Y2H	32296183
种属内	KPNA1	P52294	POLR3C	Homo sapiens	Q9BUI4	Anti Tag CoIP	33961781
种属内	KPNA1	P52294	CLK4	Homo sapiens	Q9HAZ1	Validated Y2H	25416956
种属内	KPNA1	P52294	SF1	Homo sapiens	Q15637	Y2H Fragment Pooling	26420826
种属内	KPNA1	P52294	ANP32B	Homo sapiens	Q92688	Y2H	21988832
种属内	KPNA1	P52294	ANP32B	Homo sapiens	Q92688	Confocal	21988832
种属内	KPNA1	P52294	ANP32B	Homo sapiens	Q92688	Validated Y2H	25416956
种属内	KPNA1	P52294	ANP32B	Homo sapiens	Q92688	Validated Y2H	32296183
种属内	KPNA1	P52294	ANP32B	Homo sapiens	Q92688	Anti Tag CoIP	35271311
种属内	KPNA1	P52294	ANP32B	Homo sapiens	Q92688	Y2H Prey Pooling	25416956
种属内	KPNA1	P52294	GRM1	Homo sapiens	Q13255	Anti Tag CoIP	19084525
种属内	KPNA1	P52294	GRM1	Homo sapiens	Q13255	Anti Bait CoIP	19084525
种属内	KPNA1	P52294	LMNB1	Homo sapiens	P20700	Anti Tag CoIP	26496610
种属间	KPNA1	P52294	PB2	Influenza A virus	B4URF7	Pull Down	21994455
种属间	KPNA1	P52294	PB2	Influenza A virus	P31345	X-Ray Diffraction	17310249
种属间	KPNA1	P52294	PB2	Influenza A virus	P31345	GMS	17310249
种属间	KPNA1	P52294	Q9WMX2-PRO_0000037548	Hepatitis C virus	Q9WMX2-PRO_0000037548	Y2H Prey Pooling	18985028
种属间	KPNA1	P52294	Q9WMX2-PRO_0000037548	Hepatitis C virus	Q9WMX2-PRO_0000037548	Pull Down	18985028

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Plica Syndrome

Synovitis

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07415	KPNA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	KPNA1	RGD	RGD:735064
Felis catus	KPNA1	VGNC	VGNC:102766
Mus musculus	KPNA1	MGD	MGI:103560
Bos taurus	KPNA1	VGNC	VGNC:30700
Macaca mulatta	KPNA1	VGNC	VGNC:74199
Canis familiaris	KPNA1	VGNC	VGNC:42500

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KPNA1 - karyopherin subunit alpha 1 Gene

关于 KPNA1

功能概要

KPNA1 基因产物(1)

KPNA1 蛋白结构

KPNA1 蛋白互作信息

关联疾病

直系同源

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KPNA1 - karyopherin subunit alpha 1 Gene

关于 KPNA1

功能概要

KPNA1 基因产物(1)

KPNA1 蛋白结构

KPNA1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z