2. Gene
  3. ANP32B - acidic nuclear phosphoprotein 32 family member B Gene

ANP32B - acidic nuclear phosphoprotein 32 family member B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：酸性核磷蛋白 32 家族成员 B

种属: Homo sapiens

同用名: APRIL; SSP29; PHAPI2

基因 ID: 10541 | 基因类型: protein coding

关于 ANP32B

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:97,983,341-98,015,943 (from NCBI)

This gene has 3 transcripts (splice variants), 302 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 88.8), lymph node (RPKM 73.8) and 25 other tissues.

功能概要

启用 RNA 聚合酶结合活性和组蛋白结合活性。参与多个过程，包括参与细胞凋亡过程的半胱氨酸型内肽酶活性的激活；核小体组装；和细胞核蛋白质输出的正调控。位于细胞质和核质中。与核仁共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase binding activity and histone binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; nucleosome assembly; and positive regulation of protein export from nucleus. Located in cytoplasm and nucleoplasm. Colocalizes with nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

ANP32B 基因产物(1)

mRNA Protein Name
NM_006401.3 NP_006392.1 acidic leucine-rich nuclear phosphoprotein 32 family member B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase binding IDA
IDA: 通过直接分析推断
9285060 GOA
enables histone binding IDA
IDA: 通过直接分析推断
20538007 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21988832 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
20015864 GOA
involved in negative regulation of cell differentiation IDA
IDA: 通过直接分析推断
22705300 GOA
involved in nucleosome assembly IDA
IDA: 通过直接分析推断
20538007 GOA
involved in positive regulation of protein export from nucleus IMP
IMP: 通过突变表型推断
17178712 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17178712 GOA
colocalizes with nucleolus IDA
IDA: 通过直接分析推断
9285060 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9285060 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ANP32B 蛋白结构

LRR_9

LRR_9: Leucine-rich repeat (17 - 149)

  • 0
  • 100
  • 200
  • 251 a.a.
蛋白主名 其他名称

acidic leucine-rich nuclear phosphoprotein 32 family member B

acidic (leucine-rich) nuclear phosphoprotein 32 family, member B

ANP32B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ANP32B Q92688 BEND7 Homo sapiens Q8N7W2-2
Y2H Prey Pooling
32296183
Intra ANP32B Q92688 BEND7 Homo sapiens Q8N7W2-2
Y2H Array
32296183
Intra ANP32B Q92688 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra ANP32B Q92688 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra ANP32B Q92688 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra ANP32B Q92688 YAF2 Homo sapiens Q8IY57-5
Y2H Array
32296183
Intra ANP32B Q92688 YAF2 Homo sapiens Q8IY57-5
Y2H Prey Pooling
32296183
Intra ANP32B Q92688 FAM217B Homo sapiens Q9NTX9
Validated Y2H
32296183
Intra ANP32B Q92688 FAM217B Homo sapiens Q9NTX9
Y2H Prey Pooling
32296183
Intra ANP32B Q92688 FAM217B Homo sapiens Q9NTX9
Y2H Array
32296183
Intra ANP32B Q92688 DNTTIP1 Homo sapiens Q9H147
Validated Y2H
32296183
Intra ANP32B Q92688 DNTTIP1 Homo sapiens Q9H147
Y2H Array
32296183
Intra ANP32B Q92688 DNTTIP1 Homo sapiens Q9H147
Y2H Prey Pooling
32296183
Intra ANP32B Q92688 MYNN Homo sapiens Q9NPC7
Y2H Prey Pooling
32296183
Intra ANP32B Q92688 MYNN Homo sapiens Q9NPC7
Validated Y2H
32296183
Intra ANP32B Q92688 MYNN Homo sapiens Q9NPC7
Y2H Array
32296183
Intra ANP32B Q92688 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra ANP32B Q92688 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra ANP32B Q92688 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra ANP32B Q92688 KPNA1 Homo sapiens P52294
Y2H Prey Pooling
32296183
Intra ANP32B Q92688 KPNA1 Homo sapiens P52294
Y2H Array
25416956
Intra ANP32B Q92688 KPNA1 Homo sapiens P52294
Y2H Array
32296183
Intra ANP32B Q92688 KPNA6 Homo sapiens O60684
Y2H Array
32296183
Intra ANP32B Q92688 KPNA6 Homo sapiens O60684
Y2H Prey Pooling
32296183
Intra ANP32B Q92688 KPNA5 Homo sapiens O15131
Y2H Prey Pooling
32296183
Intra ANP32B Q92688 KPNA5 Homo sapiens O15131
Y2H Array
31515488
Intra ANP32B Q92688 KPNA5 Homo sapiens O15131
Y2H Array
32296183
Intra ANP32B Q92688 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra ANP32B Q92688 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra ANP32B Q92688 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra ANP32B Q92688 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra ANP32B Q92688 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra ANP32B Q92688 SDCBP Homo sapiens O00560
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Myopathy, Congenital, Compton-North

Compton-North Congenital Myopathy

MYPCN

Congenital Lethal Myopathy, Compton-North Type
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00752 ANP32B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ANP32B VGNC VGNC:59835
Rattus norvegicus ANP32B RGD RGD:621285
Macaca mulatta ANP32B VGNC VGNC:103240
Canis familiaris ANP32B VGNC VGNC:37933
Bos taurus ANP32B VGNC VGNC:25958
Mus musculus ANP32B MGD MGI:1914878
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