KPNA5 - karyopherin subunit alpha 5 Gene

中文名称：karyopherin 亚基 alpha 5

种属: Homo sapiens

同用名: SRP6; IPOA6

关于 KPNA5

功能概要

真核细胞中分子在细胞核和细胞质之间的运输是由核孔复合体 (NPC) 介导的，它由 60-100 种蛋白质组成，分子大小可能为 1.2 亿道尔顿。小分子 (最大 70 kD) 可以通过非选择性扩散穿过核孔；较大的分子通过活跃的过程运输。大多数核蛋白包含称为核定位信号 (NLS) 的短碱性氨基酸序列。 KPNA5 蛋白属于 importin α 蛋白家族，被认为参与 NLS 依赖性蛋白向细胞核的输入。[RefSeq 提供，2008 年 7 月]

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]