NUP50 - nucleoporin 50 Gene

中文名称：核孔蛋白 50

种属: Homo sapiens

同用名: NPAP60; NPAP60L

关于 NUP50

功能概要

核孔复合体是一个巨大的结构，延伸穿过核膜，形成调节细胞核和细胞质之间大分子流动的通道。核孔蛋白是真核细胞核孔复合体的主要成分。由该基因编码的蛋白质是含有核孔蛋白的 FG 重复的成员，在 importin-alpha:beta 介导的核蛋白导入中起可溶性辅助因子的作用。在 5、6 和 14 号染色体上发现了该基因的假基因。已发现该基因编码不同亚型的两个转录变体。[RefSeq 提供，2008 年 7 月]

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]