2. Gene
  3. POLR3C - RNA polymerase III subunit C Gene

POLR3C - RNA polymerase III subunit C Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RNA 聚合酶 III 亚基 C

种属: Homo sapiens

同用名: C82; RPC3; RPC62

基因 ID: 10623 | 基因类型: protein coding

关于 POLR3C

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:145,824,200-145,844,402 (from NCBI)

This gene has 27 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 7.3), lymph node (RPKM 3.9) and 25 other tissues.

功能概要

启用单链 DNA 结合活性。参与先天免疫反应的正向调节和干扰素-β 产生的正向调节。位于核质中。 RNA 聚合酶 III 复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables single-stranded DNA binding activity. Involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Located in nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]

POLR3C 基因产物(2)

mRNA Protein Name
NM_001303456.1 NP_001290385.1 DNA-directed RNA polymerase III subunit RPC3 isoform 2
NM_006468.8 NP_006459.3 DNA-directed RNA polymerase III subunit RPC3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11416169 GOA
enables single-stranded DNA binding IDA
IDA: 通过直接分析推断
21358628 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of innate immune response IMP
IMP: 通过突变表型推断
19609254 GOA
involved in positive regulation of interferon-beta production IMP
IMP: 通过突变表型推断
19609254 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase III complex IDA
IDA: 通过直接分析推断
24107381 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POLR3C 蛋白结构

HTH_9

HTH_9: RNA polymerase III subunit RPC82 helix-turn-helix domain (7 - 67)

RNA_pol_Rpc82

RNA_pol_Rpc82: RNA polymerase III subunit RPC82 (146 - 345)

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  • 534 a.a.
蛋白主名 其他名称

DNA-directed RNA polymerase III subunit RPC3

DNA-directed III 62 kDa polypeptide

POLR3C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra POLR3C Q9BUI4 PNMA5 Homo sapiens Q96PV4
Y2H Prey Pooling
25416956
Intra POLR3C Q9BUI4 PNMA5 Homo sapiens Q96PV4
Validated Y2H
25416956
Intra POLR3C Q9BUI4 PNMA5 Homo sapiens Q96PV4
Y2H Array
25416956
Intra POLR3C Q9BUI4 TNR Homo sapiens A1L306
Y2H Prey Pooling
25416956
Intra POLR3C Q9BUI4 TNR Homo sapiens A1L306
Y2H Array
25416956
Intra POLR3C Q9BUI4 NCKIPSD Homo sapiens Q9NZQ3-3
Validated Y2H
32296183
Intra POLR3C Q9BUI4 NCKIPSD Homo sapiens Q9NZQ3-3
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 NCKIPSD Homo sapiens Q9NZQ3-3
Y2H Array
32296183
Intra POLR3C Q9BUI4 RBBP8NL Homo sapiens Q8NC74
Y2H Array
32296183
Intra POLR3C Q9BUI4 RBBP8NL Homo sapiens Q8NC74
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 CEP63 Homo sapiens Q96MT8-3
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 CEP63 Homo sapiens Q96MT8-3
Y2H Array
32296183
Intra POLR3C Q9BUI4 CAMK2B Homo sapiens Q13554-3
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 CAMK2B Homo sapiens Q13554-3
Y2H Array
32296183
Intra POLR3C Q9BUI4 UBXN1 Homo sapiens Q04323-2
Y2H Array
32296183
Intra POLR3C Q9BUI4 UBXN1 Homo sapiens Q04323-2
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra POLR3C Q9BUI4 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra POLR3C Q9BUI4 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra POLR3C Q9BUI4 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra POLR3C Q9BUI4 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra POLR3C Q9BUI4 VAX1 Homo sapiens Q5SQQ9-2
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 VAX1 Homo sapiens Q5SQQ9-2
Y2H Array
32296183
Intra POLR3C Q9BUI4 POLR3G Homo sapiens O15318
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 POLR3G Homo sapiens O15318
Anti Tag CoIP
35271311
Intra POLR3C Q9BUI4 POLR3G Homo sapiens O15318
Y2H
21358628
Intra POLR3C Q9BUI4 POLR3G Homo sapiens O15318
Y2H Array
32296183
Intra POLR3C Q9BUI4 VRTN Homo sapiens Q9H8Y1
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 VRTN Homo sapiens Q9H8Y1
Validated Y2H
32296183
Intra POLR3C Q9BUI4 VRTN Homo sapiens Q9H8Y1
Y2H Array
32296183
Intra POLR3C Q9BUI4 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
25416956
Intra POLR3C Q9BUI4 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 HAUS1 Homo sapiens Q96CS2
Y2H Array
32296183
Intra POLR3C Q9BUI4 POLR3GL Homo sapiens Q9BT43
Y2H
21358628
Intra POLR3C Q9BUI4 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra POLR3C Q9BUI4 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra POLR3C Q9BUI4 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 KPNA3 Homo sapiens O00505
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 KPNA3 Homo sapiens O00505
Y2H Array
32296183
Intra POLR3C Q9BUI4 KPNA1 Homo sapiens P52294
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 KPNA1 Homo sapiens P52294
Y2H Array
32296183
Intra POLR3C Q9BUI4 KPNA6 Homo sapiens O60684
Y2H Array
32296183
Intra POLR3C Q9BUI4 KPNA6 Homo sapiens O60684
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 KPNA5 Homo sapiens O15131
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 KPNA5 Homo sapiens O15131
Y2H Array
32296183
Intra POLR3C Q9BUI4 ANKRD23 Homo sapiens Q86SG2
Y2H Array
32296183
Intra POLR3C Q9BUI4 ANKRD23 Homo sapiens Q86SG2
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra POLR3C Q9BUI4 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra POLR3C Q9BUI4 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 SP100 Homo sapiens P23497-2
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 SP100 Homo sapiens P23497-2
Y2H Array
32296183
Intra POLR3C Q9BUI4 POLR3F Homo sapiens Q9H1D9
Anti Tag CoIP
35271311
Intra POLR3C Q9BUI4 POLR3F Homo sapiens Q9H1D9
Pull Down
21358628
Intra POLR3C Q9BUI4 KATNBL1 Homo sapiens Q9H079
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 KATNBL1 Homo sapiens Q9H079
Validated Y2H
32296183
Intra POLR3C Q9BUI4 KATNBL1 Homo sapiens Q9H079
Y2H Array
32296183
Intra POLR3C Q9BUI4 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra POLR3C Q9BUI4 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra POLR3C Q9BUI4 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra POLR3C Q9BUI4 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 KIAA0408 Homo sapiens Q6ZU52
MAPPIT
32296183
Intra POLR3C Q9BUI4 KIAA0408 Homo sapiens Q6ZU52
Y2H Array
32296183
Intra POLR3C Q9BUI4 KIAA0408 Homo sapiens Q6ZU52
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra POLR3C Q9BUI4 ENKD1 Homo sapiens Q9H0I2
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 ENKD1 Homo sapiens Q9H0I2
Y2H Array
32296183
Intra POLR3C Q9BUI4 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 CEP44 Homo sapiens Q9C0F1
Validated Y2H
32296183
Intra POLR3C Q9BUI4 CEP44 Homo sapiens Q9C0F1
Y2H Array
32296183
Intra POLR3C Q9BUI4 KLHL2 Homo sapiens O95198
Y2H Array
32296183
Intra POLR3C Q9BUI4 KLHL2 Homo sapiens O95198
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra POLR3C Q9BUI4 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra POLR3C Q9BUI4 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra POLR3C Q9BUI4 ROCK1 Homo sapiens Q13464
Y2H Prey Pooling
25416956
Intra POLR3C Q9BUI4 ROCK1 Homo sapiens Q13464
Validated Y2H
25416956
Intra POLR3C Q9BUI4 COIL Homo sapiens P38432
Y2H Prey Pooling
32296183
Intra POLR3C Q9BUI4 COIL Homo sapiens P38432
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Petroclival Meningioma
Skull Base Meningioma

Meningioma Of The Skull Base
Skull Base Cancer

Tumors Of Skull Base

Skull Base Neoplasms
Atrial Septal Defect 2

ASD2

Atrial Heart Septal Defect 2

Atrial Septal Defect-2

Asd Ii

Septal Defect, Atrial, Type 2
Chickenpox

Varicella

Varicella Nos
Hypomyelinating Leukodystrophy

Hld

Leukodystrophy, Hypomyelinating
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10857 POLR3C Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus POLR3C VGNC VGNC:64291
Rattus norvegicus POLR3C RGD RGD:1311545
Canis familiaris POLR3C VGNC VGNC:44802
Mus musculus POLR3C MGD MGI:1921664
Macaca mulatta POLR3C VGNC VGNC:76139
Bos taurus POLR3C VGNC VGNC:33147
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