1. Gene
  2. ROCK1 - Rho associated coiled-coil containing protein kinase 1 Gene

ROCK1 - Rho associated coiled-coil containing protein kinase 1 Gene

中文名称:含 Rho 相关卷曲螺旋蛋白激酶 1

种属: Homo sapiens

同用名: ROCK-I; P160ROCK

基因 ID: 6093 | 基因类型: protein coding

关于 ROCK1

Cytogenetic location: 18q11.1 Genomic coordinates (GRCh38): 18:20,946,906-21,111,813 (from NCBI)

This gene has 7 transcripts (splice variants), 212 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 22.1), fat (RPKM 16.6) and 25 other tissues.

功能概要

该基因编码一种蛋白丝氨酸/苏氨酸激酶,当与 Rho 的 GTP 结合形式结合时会被激活。小 GTPase Rho 通过在非活性 GDP 结合形式和活性 GTP 结合形式之间穿梭来调节成纤维细胞粘着斑和应力纤维的形成,以及血小板和淋巴细胞的粘附和聚集。 Rho 在胞质分裂中也是必不可少的,并且在血清反应因子的转录激活中发挥作用。这种蛋白质是 Rho 的下游效应子,磷酸化并激活 LIM 激酶,后者反过来磷酸化 cofilin,抑制其肌动蛋白解聚活性。与该基因相关的假基因也位于 18 号染色体上。[RefSeq 提供,2015 年 8 月]

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]

ROCK1 基因产物(1)

mRNA Protein Name
NM_005406.3 NP_005397.1 rho-associated protein kinase 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Rho-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18573880 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10652353 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
10652353 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Rho protein signal transduction IGI
IGI: 通过遗传相互作用推断
27160703 GOA
involved in canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
25816133 GOA
involved in cortical actin cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
25816133 GOA
involved in cortical actin cytoskeleton organization IMP
IMP: 通过突变表型推断
25816133 GOA
involved in leukocyte cell-cell adhesion IDA
IDA: 通过直接分析推断
12082081 GOA
involved in leukocyte migration IDA
IDA: 通过直接分析推断
12082081 GOA
involved in leukocyte tethering or rolling IDA
IDA: 通过直接分析推断
12082081 GOA
involved in membrane to membrane docking IDA
IDA: 通过直接分析推断
12082081 GOA
involved in negative regulation of amyloid precursor protein catabolic process IMP
IMP: 通过突变表型推断
24305806 GOA
involved in negative regulation of amyloid-beta formation IMP
IMP: 通过突变表型推断
24305806 GOA
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
19181962 GOA
involved in negative regulation of bicellular tight junction assembly IGI
IGI: 通过遗传相互作用推断
25816133 GOA
involved in negative regulation of protein binding IDA
IDA: 通过直接分析推断
18573880 GOA
involved in neuron projection arborization IGI
IGI: 通过遗传相互作用推断
27160703 GOA
involved in neuron projection development IGI
IGI: 通过遗传相互作用推断
27160703 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
18573880 GOA
involved in positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
28679962 GOA
involved in positive regulation of amyloid-beta clearance IGI
IGI: 通过遗传相互作用推断
27853422 GOA
involved in positive regulation of autophagy IGI
IGI: 通过遗传相互作用推断
27853422 GOA
involved in positive regulation of cardiac muscle hypertrophy IMP
IMP: 通过突变表型推断
28679962 GOA
involved in positive regulation of connective tissue replacement IMP
IMP: 通过突变表型推断
28679962 GOA
involved in positive regulation of dephosphorylation IMP
IMP: 通过突变表型推断
27221467 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
27853422 GOA
involved in positive regulation of phosphatase activity IMP
IMP: 通过突变表型推断
27221467 GOA
involved in protein localization to plasma membrane IGI
IGI: 通过遗传相互作用推断
25816133 GOA
involved in protein localization to plasma membrane IMP
IMP: 通过突变表型推断
25816133 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
23093407 GOA
involved in regulation of actin cytoskeleton organization IDA
IDA: 通过直接分析推断
25911094 GOA
involved in regulation of angiotensin-activated signaling pathway IMP
IMP: 通过突变表型推断
28679962 GOA
involved in regulation of cell migration IDA
IDA: 通过直接分析推断
23093407 GOA
involved in regulation of establishment of endothelial barrier IGI
IGI: 通过遗传相互作用推断
25816133 GOA
involved in regulation of establishment of endothelial barrier IMP
IMP: 通过突变表型推断
25816133 GOA
involved in regulation of keratinocyte differentiation IMP
IMP: 通过突变表型推断
19997641 GOA
involved in regulation of microtubule cytoskeleton organization IDA
IDA: 通过直接分析推断
23093407 GOA
involved in regulation of neuron differentiation IGI
IGI: 通过遗传相互作用推断
27160703 GOA
involved in regulation of synaptic vesicle endocytosis IGI
IGI: 通过遗传相互作用推断
27160703 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ROCK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (76 - 338)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (358 - 400)

HR1

HR1: Hr1 repeat (459 - 537)

Rho_Binding

Rho_Binding: Rho Binding (948 - 1014)

PH

PH: PH domain (1121 - 1312)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1354 a.a.
蛋白主名 其他名称

rho-associated protein kinase 1

p160 ROCK-1

renal carcinoma antigen NY-REN-35

ROCK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ROCK1 Q13464 TSG101 Homo sapiens Q99816
Y2H
17853893
Intra ROCK1 Q13464 TSG101 Homo sapiens Q99816
Anti Tag CoIP
17853893
Intra ROCK1 Q13464 RHOA Homo sapiens P61586
X-Ray Diffraction
14660612
Intra ROCK1 Q13464 RHOA Homo sapiens P61586
Pull Down
21281639
Intra ROCK1 Q13464 POLR3C Homo sapiens Q9BUI4
Y2H Array
25416956
Intra ROCK1 Q13464 FRMD5 Homo sapiens Q7Z6J6
Anti Bait CoIP
25448675
Intra ROCK1 Q13464 LMO2 Homo sapiens P25791
Validated Y2H
25416956
Intra ROCK1 Q13464 FAM124A Homo sapiens Q86V42
Validated Y2H
25416956
Intra ROCK1 Q13464 FAM124A Homo sapiens Q86V42
Y2H Array
25416956
Intra ROCK1 Q13464 CFAP206 Homo sapiens Q8IYR0
Y2H Prey Pooling
25416956
Intra ROCK1 Q13464 MAGEB4 Homo sapiens O15481
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Atrial Septal Defect 2

ASD2

Atrial Heart Septal Defect 2

Atrial Septal Defect-2

Asd Ii

Septal Defect, Atrial, Type 2

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Coronary Artery Vasospasm

Coronary Vasospasm

Coronary Artery Spasm

Omphalocele

Omphalocoele

Congenital Omphalocele

Exomphalos

Exumbilication

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ROCK1 MGD MGI:107927
Macaca mulatta ROCK1 VGNC VGNC:81559
Bos taurus ROCK1 VGNC VGNC:56371
Canis familiaris ROCK1 VGNC VGNC:45688
Felis catus ROCK1 VGNC VGNC:97608
Rattus norvegicus ROCK1 RGD RGD:620424
Others ROCK1 NCBI