2. Cell Cycle/DNA Damage Stem Cell/Wnt Cytoskeleton TGF-beta/Smad
  3. ROCK
  4. Verosudil hydrochloride

Verosudil hydrochloride  (Synonyms: AR-12286 hydrochloride)

目录号: HY-16758A
产品使用指南

摩尔计算器

Verosudil hydrochloride (AR-12286 hydrochloride) 是 Verosudil (HY-16758) 的盐酸盐形式。Verosudil hydrochloride 是 Rho 激酶 (ROCK) 的抑制剂，可以抑制 ROCK1 和 ROCK2，Ki 分别为 2 和 2 nM。Verosudil hydrochloride 通过增加通过小梁网的房水外流来降低眼压 (IOP)。

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Verosudil hydrochloride Chemical Structure

Verosudil hydrochloride Chemical Structure

CAS No. : 1414854-44-6

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Verosudil hydrochloride 的其他形式现货产品:

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Other Forms of Verosudil hydrochloride:

Verosudil hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 ROCK 亚型特异性产品:

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ROCK ROCK1 ROCK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Verosudil hydrochloride (AR-12286 hydrochloride) is the hydrochloride form of Verosudil (HY-16758). Verosudil hydrochloride is an inhibitor for Rho-kinase (ROCK) with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. Verosudil hydrochloride lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2].

IC50 & Target

ROCK1

2 nM (Ki)

ROCK2

2 nM (Ki)

分子量

363.86

Formula

C17H18ClN3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Verosudil hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Verosudil1414854-44-6AR-12286AR12286AR 12286ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKselectiveaqueoushumourintraocularpressureIOPglaucomaInhibitorinhibitorinhibit

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