2. Cell Cycle/DNA Damage Stem Cell/Wnt Cytoskeleton TGF-beta/Smad Metabolic Enzyme/Protease Epigenetics
  3. ROCK SGK PKA PKC
  4. PF-4950834

PF-4950834 是一种有效的、选择性的、具有口服活性的、ATP竞争性的 rho kinase 抑制剂，对 ROCK2 和 ROCK1 的 IC50 分别为 8.35 nM 和 33.12 nM。PF-4950834 抑制中性粒细胞迁移。

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PF-4950834 Chemical Structure

PF-4950834 Chemical Structure

CAS No. : 1256264-62-6

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规格 价格 是否有货 数量
1 mg ￥1920
In-stock
5 mg ￥4800
In-stock
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PF-4950834 相关抗体

Top Publications Citing Use of Products

查看 ROCK 亚型特异性产品:

查看所有亚型
ROCK ROCK1 ROCK2

查看 SGK 亚型特异性产品:

查看所有亚型
SGK1 SGK3

查看 PKA 亚型特异性产品:

查看所有亚型
PKA PKAR

查看 PKC 亚型特异性产品:

查看所有亚型
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive rho kinase inhibitor with IC50 values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration[1].

IC50 & Target

ROCK2

8.35 nM (IC50)

ROCK1

33.12 nM (IC50)

PKCη

756 nM (IC50)

PKA

424 nM (IC50)

体外研究
(In Vitro)

PF-4950834 shows inhibition against the AGC (cAMP-dependent protein kinase/protein kinase G/protein kinase C) kinase family with IC50 values of 8.35, 33.12, 102, 216, 321, 384, 411, 424, 457, 578, 736, 756 and 2900 nM for ROCK2, ROCK1, PRKG1, PKN1, SGK2, PRKG2, MSK1, PKA, PRKX, MSK2, P70S6K, PKCη and SGK1, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PF-4950834 相关抗体:
分子量

345.39

Formula

C21H19N3O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

PF-4950834 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-49508341256264-62-6PF4950834PF 4950834ROCKSGKPKAPKCRho-associated protein kinaseRho-associated kinaseRho-kinaseROKSerum-glucocorticoid regulated kinaseSerum and glucocorticoid-regulated kinaseProtein kinase AProtein kinase Cneutrophil migrationanti-inflammatoryAGC kinase familyorally bioavailableInhibitorinhibitorinhibit

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产品名称：
PF-4950834
目录号：
HY-122011
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