2. Cell Cycle/DNA Damage Stem Cell/Wnt Cytoskeleton TGF-beta/Smad
  3. ROCK
  4. GSK269962A hydrochloride

GSK269962A hydrochloride  (Synonyms: GSK 269962 hydrochloride)

目录号: HY-15556A
产品使用指南

摩尔计算器

GSK269962A hydrochloride (GSK 269962 hydrochloride) 是一种有效的 ROCK 抑制剂，作用于重组人 ROCK1 和 ROCK2，IC50 分别为 1.6 和 4 nM。GSK269962A hydrochloride 具有抗炎和血管舒张作用。

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GSK269962A hydrochloride Chemical Structure

GSK269962A hydrochloride Chemical Structure

CAS No. : 2095432-71-4

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GSK269962A hydrochloride 的其他形式现货产品:

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Other Forms of GSK269962A hydrochloride:

GSK269962A hydrochloride 相关抗体

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查看 ROCK 亚型特异性产品:

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ROCK ROCK1 ROCK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK269962A hydrochloride (GSK 269962 hydrochloride) is a potent ROCK inhibitor with IC50s of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively. GSK269962A hydrochloride has anti-inflammatory and vasodilatory activities[1].

IC50 & Target[1]

ROCK1

1.6 nM (IC50)

ROCK2

4 nM (IC50)

RSK1

132 nM (IC50)

MSK1

49 nM (IC50)

AKT1

955 nM (IC50)

AKT2

1350 nM (IC50)

AKT3

1510 nM (IC50)

CDK2

3500 nM (IC50)

GSK3α

1260 nM (IC50)

体外研究
(In Vitro)

GSK269962A has an IC50 of 1.6 nM toward recombinant human ROCK1. GSK269962A exhibits more than 30-fold selectivity against a panel of serine/threonine kinases[1].
GSK269962A induces vasorelaxation in preconstricted rat aorta with an IC50 of 35 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GSK269962A hydrochloride 相关抗体:
体内研究
(In Vivo)

GSK269962A is a potent antihypertensive agent. GSK269962A (0.3, 1, and 3 mg/kg; oral gavage) induces a dose-dependent reduction in blood pressure in spontaneously hypertensive rat (SHR). The reduction of blood pressure is acute and substantial[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (350-400g)[1]
Dosage: 0.3, 1, and 3 mg/kg
Administration: Oral gavage; 12 hours
Result: Induced a dose-dependent reduction in blood pressure.
分子量

607.06

Formula

C29H31ClN8O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK269962A hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK269962A2095432-71-4GSK 269962GSK269962GSK-269962ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKROCK1ROCK2anti-inflammatoryvasodilatorycardiovascularantihypertensivebloodpressureInhibitorinhibitorinhibit

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目录号：
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