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  2. POLR3G - RNA polymerase III subunit G Gene

POLR3G - RNA polymerase III subunit G Gene

中文名称:RNA 聚合酶 III 亚基 G

种属: Homo sapiens

同用名: C31; RPC7; RPC32

基因 ID: 10622 | 基因类型: protein coding

关于 POLR3G

Cytogenetic location: 5q14.3 Genomic coordinates (GRCh38): 5:90,473,929-90,514,557 (from NCBI)

This gene has 7 transcripts (splice variants) and 19 orthologues. Broad expression in testis (RPKM 1.8), esophagus (RPKM 1.0) and 24 other tissues.

功能概要

启用染色质结合活性。参与先天免疫反应的正向调节;干扰素-β 产生的正向调节;和 RNA 聚合酶 III 的转录。作用于细胞群增殖的上游或内部。位于细胞质和核体中。 RNA 聚合酶 III 复合物的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables chromatin binding activity. Involved in positive regulation of innate immune response; positive regulation of interferon-beta production; and transcription by RNA polymerase III. Acts upstream of or within cell population proliferation. Located in cytosol and nuclear body. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]

POLR3G 基因产物(5)

mRNA Protein Name
NM_001370351.1 NP_001357280.1 DNA-directed RNA polymerase III subunit RPC7 isoform 1
NM_001370352.1 NP_001357281.1 DNA-directed RNA polymerase III subunit RPC7 isoform 2
NM_001370353.1 NP_001357282.1 DNA-directed RNA polymerase III subunit RPC7 isoform 2
NM_001370354.1 NP_001357283.1 DNA-directed RNA polymerase III subunit RPC7 isoform 1
NM_006467.3 NP_006458.2 DNA-directed RNA polymerase III subunit RPC7 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
24107381 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20154270 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell population proliferation IEP
IEP: 通过表达模式推断
24107381 GOA
involved in positive regulation of innate immune response IMP
IMP: 通过突变表型推断
19609254 GOA
involved in positive regulation of interferon-beta production IMP
IMP: 通过突变表型推断
19609254 GOA
involved in transcription by RNA polymerase III IDA
IDA: 通过直接分析推断
20154270 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase III complex IDA
IDA: 通过直接分析推断
24107381 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20154270 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

POLR3G 蛋白结构

RNA_pol_3_Rpc31

RNA_pol_3_Rpc31: DNA-directed RNA polymerase III subunit Rpc31 (1 - 223)

  • 0
  • 100
  • 200
  • 223 a.a.
蛋白主名 其他名称

DNA-directed RNA polymerase III subunit RPC7

DNA-directed RNA polymerase III 32 kDa polypeptide

POLR3G 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra POLR3G O15318 POLR3C Homo sapiens Q9BUI4
Anti Tag CoIP
35271311
Intra POLR3G O15318 POLR3C Homo sapiens Q9BUI4
Anti Tag CoIP
20154270
Intra POLR3G O15318 POLR3C Homo sapiens Q9BUI4
Validated Y2H
32296183
Intra POLR3G O15318 POLR3F Homo sapiens Q9H1D9
Anti Tag CoIP
35271311
Intra POLR3G O15318 POLR3F Homo sapiens Q9H1D9
Anti Tag CoIP
20154270
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cerebellofaciodental Syndrome

Cerebellar-Facial-Dental Syndrome

CFDS

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus POLR3G RGD RGD:1593792
Canis familiaris POLR3G VGNC VGNC:44805
Bos taurus POLR3G VGNC VGNC:33151
Macaca mulatta POLR3G VGNC VGNC:84480
Mus musculus POLR3G MGD MGI:1914736