2. Gene
  3. DCPS - decapping enzyme, scavenger Gene

DCPS - decapping enzyme, scavenger Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：脱帽酶，清除因子

种属: Homo sapiens

同用名: ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015

基因 ID: 28960 | 基因类型: protein coding

关于 DCPS

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:126,304,060-126,350,005 (from NCBI)

This gene has 4 transcripts (splice variants), 211 orthologues and is associated with 2 phenotypes. Ubiquitous expression in lymph node (RPKM 6.1), gall bladder (RPKM 5.3) and 25 other tissues.

功能概要

该基因编码焦磷酸酶组氨酸三联体家族的一个成员，该家族去除含有 5′ 的短 mRNA 片段。 mRNA 帽结构，出现在 3′ → 5′脱腺苷酸化和外泌体介导的周转后的 mRNA 衰变途径。该酶水解帽结构 (7-甲基鸟苷核苷三磷酸) 的三磷酸键，产生 7-甲基鸟苷一磷酸和核苷二磷酸。它保护细胞免受这些短的加帽 mRNA 片段的潜在毒性积累，并调节其他帽结合蛋白的活性，这些蛋白的积累会抑制这些蛋白。它还充当 pre-mRNA 剪接和 MicroRNA 转换的转录物特异性调节剂。[RefSeq 提供，2017 年 4 月]

This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This Enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and MicroRNA turnover. [provided by RefSeq, Apr 2017]

DCPS 基因产物(2)

mRNA Protein Name
NM_001350236.2 NP_001337165.1 m7GpppX diphosphatase isoform 1
NM_014026.6 NP_054745.1 m7GpppX diphosphatase isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity IDA
IDA: 通过直接分析推断
12198172 GOA
enables RNA 7-methylguanosine cap binding IDA
IDA: 通过直接分析推断
12198172 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16140270 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA cis splicing, via spliceosome IDA
IDA: 通过直接分析推断
18426921 GOA
involved in mRNA methylguanosine-cap decapping IDA
IDA: 通过直接分析推断
26049109 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18441014 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12871939 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DCPS 蛋白结构

DcpS

DcpS: Scavenger mRNA decapping enzyme (DcpS) N-terminal (44 - 146)

DcpS_C

DcpS_C: Scavenger mRNA decapping enzyme C-term binding (174 - 291)

  • 0
  • 100
  • 200
  • 300
  • 337 a.a.
蛋白主名 其他名称

m7GpppX diphosphatase

5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase

DCPS 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DCPS Q96C86 KPNA2 Homo sapiens P52292
Y2H Array
32296183
Intra DCPS Q96C86 KPNA2 Homo sapiens P52292
Y2H Prey Pooling
32296183
Intra DCPS Q96C86 KPNA6 Homo sapiens O60684
Y2H Prey Pooling
32296183
Intra DCPS Q96C86 KPNA6 Homo sapiens O60684
Y2H Array
32296183
Intra DCPS Q96C86 DCPS Homo sapiens Q96C86
Y2H Prey Pooling
32296183
Intra DCPS Q96C86 DCPS Homo sapiens Q96C86
Validated Y2H
32296183
Intra DCPS Q96C86 CHST4 Homo sapiens Q8NCG5
Y2H Array
21988832
Intra DCPS Q96C86 DCPS Homo sapiens Q96C86
Y2H Array
32296183
Intra DCPS Q96C86 KPNA5 Homo sapiens O15131
Y2H Prey Pooling
32296183
Intra DCPS Q96C86 KPNA5 Homo sapiens O15131
Y2H Array
32296183
Intra DCPS Q96C86 SSRP1 Homo sapiens Q08945
Crosslink
30021884
Intra DCPS Q96C86 GPC5 Homo sapiens P78333
Y2H Array
21988832
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Al-Raqad Syndrome

ARS
Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid
Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy
Spinal Muscular Atrophy, Type I

Werdnig-Hoffmann Disease

SMA1

Spinal Muscular Atrophy 1

Sma I

Sma, Infantile Acute Form

Muscular Atrophy, Infantile

Spinal Muscular Atrophy-1

Hmn Proximal Type I

Infantile Muscular Atrophy

Proximal Spinal Muscular Atrophy Type 1

Sma Type 1

Sma Type I

Sma-I

Hereditary Motor Neuropathy Proximal Type I

Progressive Muscular Atrophy Of Infancy

Proximal Spinal Muscular Atrophy, Type 1

Werdnig Hoffmann Disease

Infantile Spinal Muscular Atrophy

Infantile-Onset Spinal Muscular Atrophy

Proximal Hereditary Motor Neuropathy Type I

Sma Infantile Acute Form

Spinal Muscular Atrophy Type I

Werdnig-Hoffman Disease

Atrophy, Muscular, Spinal, Type 1
Spinal Muscular Atrophy, Type Iii

SMA3

Juvenile Spinal Muscular Atrophy

Kugelberg-Welander Disease

Sma Iii

Kugelberg-Welander Syndrome

Kws

Muscular Atrophy, Juvenile

Spinal Muscular Atrophy, Mild Childhood And Adolescent Form

Spinal Muscular Atrophy-3

Spinal Muscular Atrophy Type 3

Spinal Muscular Atrophy, Type Iii, Modifier Of

Type Iii Spinal Muscular Atrophy

Sma 3

Proximal Spinal Muscular Atrophy Type 3

Sma Type 3

Sma Type Iii

Sma-Iii

Spinal Muscular Atrophy 3

Spinal Muscular Atrophy Mild Childhood And Adolescent Form

Spinal Muscular Atrophy Type Iii

Wohlfart-Kugelberg-Welander Disease

Atrophy, Muscular, Spinal, Type Iii
Childhood Spinal Muscular Atrophy

Spinal Muscular Atrophies Of Childhood

Survival Motor Neuron Spinal Muscular Atrophy
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108599 DCP-LA ≥98.0% 否
HY-102020 RG3039 Inhibitor 99.62% 否
HY-138147 DCP-Rho1 / 否
HY-155771 1-DCP / 否
HY-RS03584 DCP1A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03585 DCP1B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03586 DCP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03587 DCPS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-122604 PF-DcpSi / 否
HY-131933 DCP-Bio3 / 否
HY-W087905 2,3-Dimethyl-2,3-diphenylbutane ≥95.0% 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DCPS RGD RGD:628887
Mus musculus DCPS MGD MGI:1916555
Macaca mulatta DCPS VGNC VGNC:71816
Felis catus DCPS VGNC VGNC:61375
Canis familiaris DCPS VGNC VGNC:39811
Bos taurus DCPS VGNC VGNC:27922
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z