SSRP1 - structure specific recognition protein 1 Gene

中文名称：结构特异性识别蛋白 1

种属: Homo sapiens

同用名: FACT; T160; FACT80

关于 SSRP1

功能概要

该基因编码的蛋白质是异二聚体的一个亚基，与 SUPT16H 一起形成染色质转录延长因子 FACT。 FACT 与组蛋白 H2A/H2B 特异性相互作用以影响核小体分解和转录延伸。事实和顺铂损伤的 DNA 可能对顺铂的抗癌机制至关重要。这种编码的蛋白质包含一个高迁移率组框，它很可能构成顺铂修饰 DNA 的结构识别元件。该蛋白质还充当转录激活因子 p63 的共激活因子。已经描述了该基因的可变剪接转录变体，但其全长性质尚不清楚。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the Anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]