SUPT16H - SPT16 homolog, facilitates chromatin remodeling subunit Gene

中文名称：SPT16 同系物，促进染色质重塑亚基

种属: Homo sapiens

同用名: CDC68; SPT16; NEDDFAC; FACTP140; SPT16/CDC68

关于 SUPT16H

功能概要

蛋白质编码基因的转录可以在裸露的 DNA 上重建，仅使用一般转录因子和 RNA 聚合酶 II。然而，这个最小系统不能转录包装成染色质的 DNA，这表明辅助因素可能有助于获取 DNA。其中一个因素 FACT (促进染色质转录) 特异性地与组蛋白 H2A/H2B 相互作用，以影响核小体分解和转录延伸。 FACT 由一个 80 kDa 亚基和一个 140 kDa 亚基组成；该基因编码 140 kDa 亚基。[RefSeq 提供，2009 年 2 月]

Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]