CLK4 - CDC like kinase 4 Gene

中文名称：CDC 样激酶 4

种属: Homo sapiens

关于 CLK4

功能概要

该基因编码的蛋白质属于 CDC2 样蛋白激酶 (CLK) 家族。这种蛋白激酶可以与富含丝氨酸和精氨酸 (SR) 的蛋白质相互作用并磷酸化，已知这些蛋白质在剪接体的形成中起重要作用，因此可能参与选择性剪接的调节。对以色列沙鼠 Psammomys obesus 的研究表明，泛素样 5 (UBL5/BEACON) 是一种高度保守的泛素样蛋白，可能与该激酶相互作用并调节其活性。已观察到多个选择性剪接的转录物变体，但尚未确定其全长性质。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]