2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK
  3. CDK DYRK
  4. MU1210

MU1210 (compound 12f) 是一种 CDC 样激酶 Clk1、Clk2 和 Clk4 的抑制剂 (IC50 分别为 8、20 和 12 nM)，对 HIPK1 和 DYRK2 的 IC50 为 187 和 1309 nM。MU1210 还具有有利的药代动力学特征 (小鼠，10 mg/kg，腹腔注射：Cmax = 1.24 μM，T1/2 = 58 分钟；未观察到急性毒性)。

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MU1210 Chemical Structure

MU1210 Chemical Structure

CAS No. : 2275601-87-9

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规格 是否有货
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100 mg   询价  
250 mg   询价  

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MU1210 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

查看 DYRK 亚型特异性产品:

查看所有亚型
DYRK1 DYRK2 DYRK3 DYRK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MU1210 (compound 12f) is an inhibitor of CDC-like kinases Clk1, Clk2, and Clk4 (with IC50 values of 8, 20, and 12 nM respectively), and its IC50 for HIPK1 and DYRK2 are 187 and 1309 nM. MU1210 also has favorable pharmacokinetic characteristics (in mice, 10 mg/kg, intraperitoneal injection: Cmax = 1.24 μM, T1/2 = 58 minutes; no acute toxicity observed)[1].

IC50 & Target

CLK1

8 nM (IC50)

CLK2

20 nM (IC50)

CLK4

12 nM (IC50)

HIPK1

187 nM (IC50)

DYRK2

1309 nM (IC50)

分子量

352.39

Formula

C22H16N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MU1210 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MU12102275601-87-9MU 1210MU-1210CDKDYRKCyclin dependent kinaseDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinasepharmacokinetic characteristicsmicecancerInhibitorinhibitorinhibit

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HY-125290
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