2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK
  3. CDK DYRK
  4. Leucettinib-92

Leucettinib-92 (compound 92) 是 DYRK/CLK 激酶的抑制剂，IC50s 分别为 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), 1.0 μM (DYRK3), 0.52 μM (DYRK4), 2.78 μM (GSK3)。

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Leucettinib-92 Chemical Structure

Leucettinib-92 Chemical Structure

CAS No. : 2732859-57-1

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Leucettinib-92 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

查看 DYRK 亚型特异性产品:

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DYRK1 DYRK2 DYRK3 DYRK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Leucettinib-92 (compound 92) is an inhibitor of DYRK/CLK kinase, The IC50s are 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), respectively. 1.0 μM (DYRK3), 0.52 μM (DYRK4), 2.78 μM (GSK3)[1].

IC50 & Target

IC50: 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), 1.0 μM (DYRK3), 0.52 μM (DYRK4), 2.78 μM (GSK3)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HT-22 IC50
6.3 μM
Compound: 22
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 36876904]
体外研究
(In Vitro)

Leucettinib-92 (0.1-10 μM; 3 min) 与 SH-SY5Y 细胞中的 DYRK1A 结合，诱导其稳定直到 52°C 以上的熔化温度。Leucettinib-92 (1 μM) 抑制 2 种 DYRK1A 底物 (Thr212-Tau and Thr286-cyclin D1) 的磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Leucettinib-92 相关抗体:
分子量

378.49

Formula

C21H22N4OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Leucettinib-92 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leucettinib-922732859-57-1Leucettinib92Leucettinib 92CDKDYRKCyclin dependent kinaseDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseInhibitorinhibitorinhibit

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