1. Gene
  2. SRRM4 - serine/arginine repetitive matrix 4 Gene

SRRM4 - serine/arginine repetitive matrix 4 Gene

中文名称:丝氨酸/精氨酸重复矩阵 4

种属: Homo sapiens

同用名: nSR100; KIAA1853; MU-MB-2.76

基因 ID: 84530 | 基因类型: protein coding

关于 SRRM4

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:118,981,541-119,163,051 (from NCBI)

This gene has 7 transcripts (splice variants) and 108 orthologues. Biased expression in brain (RPKM 5.9) and adrenal (RPKM 0.7).

功能概要

SRRM4 促进目标 mRNA 中神经特异性外显子的选择性剪接和包含 (Calarco 等人,2009 [PubMed 19737518]) 。[OMIM 提供,2009 年 10 月]

SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).[supplied by OMIM, Oct 2009]

SRRM4 基因产物(1)

mRNA Protein Name
NM_194286.4 NP_919262.2 serine/arginine repetitive matrix protein 4
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
29961578 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SRRM4 蛋白结构

SRRM_C

SRRM_C: Serine/arginine repetitive matrix protein C-terminus (457 - 522)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 611 a.a.
蛋白主名 其他名称

serine/arginine repetitive matrix protein 4

medulloblastoma antigen MU-MB-2.76

SRRM4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SRRM4 A7MD48 FAM9B Homo sapiens Q8IZU0
Validated Y2H
32296183
种属内
SRRM4 A7MD48 LUZP4 Homo sapiens Q9P127
Validated Y2H
32296183
种属内
SRRM4 A7MD48 ZNF699 Homo sapiens Q32M78
Y2H Array
32296183
种属内
SRRM4 A7MD48 ZNF699 Homo sapiens Q32M78
Y2H Prey Pooling
32296183
种属内
SRRM4 A7MD48 ZNF699 Homo sapiens Q32M78
Validated Y2H
32296183
种属内
SRRM4 A7MD48 AKAP17A Homo sapiens Q02040
Validated Y2H
32296183
种属内
SRRM4 A7MD48 AKAP17A Homo sapiens Q02040
Y2H Array
32296183
种属内
SRRM4 A7MD48 AKAP17A Homo sapiens Q02040
Y2H Prey Pooling
32296183
种属内
SRRM4 A7MD48 SNRNP70 Homo sapiens P08621
Y2H Array
32296183
种属内
SRRM4 A7MD48 SNRNP70 Homo sapiens P08621
Y2H Prey Pooling
32296183
种属内
SRRM4 A7MD48 SNRNP70 Homo sapiens P08621
Validated Y2H
32296183
种属内
SRRM4 A7MD48 SRRM1 Homo sapiens Q8IYB3
Validated Y2H
32296183
种属内
SRRM4 A7MD48 ZNF286A Homo sapiens Q9HBT8
Validated Y2H
32296183
种属内
SRRM4 A7MD48 SRSF11 Homo sapiens Q05519-2
Validated Y2H
32296183
种属内
SRRM4 A7MD48 CLK1 Homo sapiens P49759-3
Validated Y2H
32296183
种属内
SRRM4 A7MD48 ZRSR2P1 Homo sapiens Q15695
Validated Y2H
32296183
种属内
SRRM4 A7MD48 RBM25 Homo sapiens P49756
Validated Y2H
32296183
种属内
SRRM4 A7MD48 ZNF124 Homo sapiens Q15973
Validated Y2H
32296183
种属内
SRRM4 A7MD48 CDC37 Homo sapiens Q16543
Validated Y2H
32296183
种属内
SRRM4 A7MD48 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
种属内
SRRM4 A7MD48 LUC7L2 Homo sapiens Q9Y383
Y2H Prey Pooling
32296183
种属内
SRRM4 A7MD48 LUC7L2 Homo sapiens Q9Y383
Validated Y2H
32296183
种属内
SRRM4 A7MD48 LUC7L2 Homo sapiens Q9Y383
Y2H Array
32296183
种属内
SRRM4 A7MD48 RBM39 Homo sapiens Q14498
Validated Y2H
32296183
种属内
SRRM4 A7MD48 RNPS1 Homo sapiens Q15287
Validated Y2H
32296183
种属内
SRRM4 A7MD48 WDR5 Homo sapiens P61964
Validated Y2H
32296183
种属内
SRRM4 A7MD48 U2AF1 Homo sapiens Q01081
Validated Y2H
32296183
种属内
SRRM4 A7MD48 CLK4 Homo sapiens Q9HAZ1
Validated Y2H
32296183
种属内
SRRM4 A7MD48 C16orf87 Homo sapiens Q6PH81
Validated Y2H
32296183
种属内
SRRM4 A7MD48 ZRSR2 Homo sapiens Q15696
Validated Y2H
32296183
种属内
SRRM4 A7MD48 RSRC1 Homo sapiens Q96IZ7
Validated Y2H
32296183
种属内
SRRM4 A7MD48 MMTAG2 Homo sapiens Q9BU76
Validated Y2H
32296183
种属内
SRRM4 A7MD48 SNIP1 Homo sapiens Q8TAD8
Validated Y2H
32296183
种属内
SRRM4 A7MD48 SNIP1 Homo sapiens Q8TAD8
Y2H Prey Pooling
32296183
种属内
SRRM4 A7MD48 SNIP1 Homo sapiens Q8TAD8
Y2H Array
32296183
种属内
SRRM4 A7MD48 RBMX2 Homo sapiens Q9Y388
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Deafness, Autosomal Dominant 27

DFNA27

Autosomal Dominant Nonsyndromic Deafness 27

Autosomal Dominant Deafness 27

Deafness, Autosomal Dominant, 27

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma

Adenocarcinoma Of Prostate

ST12

Prostate Adenocarcinoma 1

Pac1

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SRRM4 MGD MGI:1916205
Canis familiaris SRRM4 VGNC VGNC:46814
Bos taurus SRRM4 VGNC VGNC:35295
Macaca mulatta SRRM4 VGNC VGNC:78011
Rattus norvegicus SRRM4 RGD RGD:1560213
Felis catus SRRM4 VGNC VGNC:65692