1. Gene
  2. ZRSR2 - zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 Gene

ZRSR2 - zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 Gene

中文名称:锌指 CCCH 型、RNA 结合基序和富丝氨酸/精氨酸 2

种属: Homo sapiens

同用名: URP; ZC3H22; U2AF1L2; U2AF1RS2; U2AF1-RS2

基因 ID: 8233 | 基因类型: protein coding

关于 ZRSR2

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,790,484-15,823,260 (from NCBI)

This gene has 6 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 77 phenotypes. Ubiquitous expression in lymph node (RPKM 3.8), spleen (RPKM 3.5) and 25 other tissues.

功能概要

该基因编码一个重要的剪接因子。编码的蛋白质与 U2 辅助因子异二聚体结合,这是识别前 mRNA 剪接中功能性 3' 剪接位点所必需的,并且可能在剪接体组装过程中的网络相互作用中发挥作用。[RefSeq 提供,2008 年 7 月]

This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]

ZRSR2 基因产物(1)

mRNA Protein Name
NM_005089.4 NP_005080.1 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables pre-mRNA 3'-splice site binding IDA
IDA: 通过直接分析推断
21041408 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9237760 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA splicing, via spliceosome IMP
IMP: 通过突变表型推断
9237760 GOA
involved in spliceosomal complex assembly IMP
IMP: 通过突变表型推断
21041408 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of U12-type spliceosomal complex IDA
IDA: 通过直接分析推断
15146077 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ZRSR2 蛋白结构

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (168 - 192)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (246 - 302)

  • 0
  • 100
  • 200
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  • 400
  • 482 a.a.
蛋白主名 其他名称

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

U2 small nuclear ribonucleoprotein auxiliary factor, small subunit 2

ZRSR2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZRSR2 Q15696 TEPSIN Homo sapiens Q96N21 32296183
种属内
ZRSR2 Q15696 TEPSIN Homo sapiens Q96N21 32296183
种属内
ZRSR2 Q15696 TEPSIN Homo sapiens Q96N21 32296183
种属内
ZRSR2 Q15696 REP15 Homo sapiens Q6BDI9 32296183
种属内
ZRSR2 Q15696 REP15 Homo sapiens Q6BDI9 32296183
种属内
ZRSR2 Q15696 REP15 Homo sapiens Q6BDI9 32296183
种属内
ZRSR2 Q15696 ZRSR2P1 Homo sapiens Q15695 33961781
种属内
ZRSR2 Q15696 ZRSR2P1 Homo sapiens Q15695 28514442
种属内
ZRSR2 Q15696 ZRSR2P1 Homo sapiens Q15695 32296183
种属内
ZRSR2 Q15696 ZRSR2P1 Homo sapiens Q15695 32296183
种属内
ZRSR2 Q15696 SSX2IP Homo sapiens Q9Y2D8 25416956
种属内
ZRSR2 Q15696 SSX2IP Homo sapiens Q9Y2D8 25416956
种属内
ZRSR2 Q15696 SSX2IP Homo sapiens Q9Y2D8 33961781
种属内
ZRSR2 Q15696 CCNL1 Homo sapiens Q9UK58 32296183
种属内
ZRSR2 Q15696 CCNL1 Homo sapiens Q9UK58 32296183
种属内
ZRSR2 Q15696 CCNL1 Homo sapiens Q9UK58 32296183
种属内
ZRSR2 Q15696 LUC7L2 Homo sapiens Q9Y383 32296183
种属内
ZRSR2 Q15696 LUC7L2 Homo sapiens Q9Y383 32296183
种属内
ZRSR2 Q15696 LUC7L2 Homo sapiens Q9Y383 32296183
种属内
ZRSR2 Q15696 SRRM4 Homo sapiens A7MD48 32296183
种属内
ZRSR2 Q15696 SRRM4 Homo sapiens A7MD48 32296183
种属内
ZRSR2 Q15696 SRPK1 Homo sapiens Q96SB4 33961781
种属内
ZRSR2 Q15696 SRPK1 Homo sapiens Q96SB4 28514442
种属内
ZRSR2 Q15696 SRPK2 Homo sapiens P78362 25416956
种属内
ZRSR2 Q15696 SRPK2 Homo sapiens P78362 33961781
种属内
ZRSR2 Q15696 SRPK2 Homo sapiens P78362 32296183
种属内
ZRSR2 Q15696 SRPK2 Homo sapiens P78362 23602568
种属内
ZRSR2 Q15696 SRPK2 Homo sapiens P78362 32296183
种属内
ZRSR2 Q15696 SDCBP2 Homo sapiens Q9H190 32296183
种属内
ZRSR2 Q15696 SDCBP2 Homo sapiens Q9H190 31515488
种属内
ZRSR2 Q15696 CLK2 Homo sapiens P49760 25416956
种属内
ZRSR2 Q15696 SDCBP2 Homo sapiens Q9H190 25416956
种属内
ZRSR2 Q15696 CLK2 Homo sapiens P49760 25416956
种属内
ZRSR2 Q15696 SDCBP2 Homo sapiens Q9H190 32296183
种属内
ZRSR2 Q15696 SDCBP2 Homo sapiens Q9H190 32296183
种属内
ZRSR2 Q15696 SDCBP2 Homo sapiens Q9H190 25416956
种属内
ZRSR2 Q15696 SRSF5 Homo sapiens Q13243 32296183
种属内
ZRSR2 Q15696 SRSF5 Homo sapiens Q13243 32296183
种属内
ZRSR2 Q15696 DVL3 Homo sapiens Q92997 32296183
种属内
ZRSR2 Q15696 DVL3 Homo sapiens Q92997 32296183
种属内
ZRSR2 Q15696 DVL3 Homo sapiens Q92997 32296183
种属内
ZRSR2 Q15696 CLK2 Homo sapiens P49760 32296183
种属内
ZRSR2 Q15696 CLK2 Homo sapiens P49760 32296183
种属内
ZRSR2 Q15696 TNFAIP8L1 Homo sapiens Q8WVP5 32296183
种属内
ZRSR2 Q15696 TNFAIP8L1 Homo sapiens Q8WVP5 32296183
种属内
ZRSR2 Q15696 TNFAIP8L1 Homo sapiens Q8WVP5 32296183
种属内
ZRSR2 Q15696 KHDC4 Homo sapiens Q7Z7F0-4 32296183
种属内
ZRSR2 Q15696 KHDC4 Homo sapiens Q7Z7F0-4 32296183
种属内
ZRSR2 Q15696 KHDC4 Homo sapiens Q7Z7F0-4 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Holoprosencephaly 1

Arhinencephaly

HPE1

Cyclopia

Holoprosencephaly, Familial Alobar

Hpe, Familial

Hpec

Demyer Sequence

Holoprosencephaly-1

Holoprosencephaly

Holoprosencephaly Sequence

Hpe

Hpe - [Holoprosencephaly]

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Vexas Syndrome

VEXAS

Vexas Syndrome, Somatic

Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory And Somatic Syndrome

Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic Syndrome

Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic

Chronic Leukemia

Adult Chronic Leukemia

Cll

Cml

Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative

Atypical Chronic Myeloid Leukemia

Atypical Chronic Myeloid Leukaemia

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Acml

Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Atypical Cml

Subacute Myeloid Leukemia

Subacute Myelogenous Leukaemia

Subacute Myeloid Leukaemia

Subacute Myelosis

Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission

Subacute Monocytic Leukaemia Without Mention Of Remission

Subacute Monocytic Leukaemia

Microcephalic Osteodysplastic Primordial Dwarfism, Type I

Taybi-Linder Syndrome

Brachymelic Primordial Dwarfism

Cephaloskeletal Dysplasia

Low-Birth-Weight Dwarfism With Skeletal Dysplasia

Microcephalic Osteodysplastic Primordial Dwarfism Type I

Osteodysplastic Primordial Dwarfism Type I

Primordial Microcephalic Dwarfism, Crachami Type

Osteodysplastic Primordial Dwarfism, Type 1

MOPD1

Mopd I

Mopd

Osteodysplastic Primordial Dwarfism, Type I

Tals

Microcephalic Osteodysplastic Primordial Dwarfism Type 1

Mopd 1

Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3

Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii

Mopd Types I And Iii

Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type

Primordial Microcephalic Dwarfism Crachami Type

Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1

Myelodysplastic/Myeloproliferative Neoplasm

Myelodysplastic-Myeloproliferative Diseases

Myelodysplastic/Myeloproliferative Disease

Myelodysplastic Myeloproliferative Cancer

Myelodysplastic Myeloproliferative Disease

Myeloproliferative/Myelodysplastic Syndromes

Chronic Myelomonocytic Leukemia

Leukemia, Myelomonocytic, Chronic

Cmml

Leukemia Myelomonocytic Chronic

Cmml - [Chronic Myelomonocytic Leukaemia]

Chronic Myelomonocytic Leukaemia Without Mention Of Remission

Chronic Monocytic Leukaemia

Chronic Monocytoid Leukaemia

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Essential Thrombocythemia

Essential Thrombocytosis

Familial Thrombocytosis

Hemorrhagic Thrombocythemia

Hereditary Thrombocythemia

Primary Thrombocytosis

Idiopathic Thrombocythemia

Primary Thrombocythemia

Thrombocythemia, Essential

Essential Thrombocythaemia

Et

Familial Thrombocythemia

Thrombocythemia Essential

Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic

JMML

Leukemia, Juvenile Myelomonocytic, Somatic

Juvenile Chronic Myelomonocytic Leukemia

Juvenile Chronic Myelogenous Leukemia

Leukemia, Myelomonocytic, Juvenile

Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To

Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ZRSR2 RGD RGD:1559763
Mus musculus ZRSR2 MGD MGI:103287