1. Gene
  2. MACROD1 - mono-ADP ribosylhydrolase 1 Gene

MACROD1 - mono-ADP ribosylhydrolase 1 Gene

中文名称:单-ADP 核糖水解酶 1

种属: Homo sapiens

同用名: LRP16

基因 ID: 28992 | 基因类型: protein coding

关于 MACROD1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:63,998,558-64,166,113 (from NCBI)

This gene has 8 transcripts (splice variants), 170 orthologues and 2 paralogues. Broad expression in kidney (RPKM 9.5), prostate (RPKM 2.7) and 22 other tissues.

功能概要

启用 ADP-核糖基谷氨酸水解酶活性和脱乙酰酶活性。参与细胞对 DNA 损伤刺激的反应;肽基谷氨酸 ADP-脱核糖基化;和嘌呤核苷代谢过程。位于核质中。 [由基因组资源联盟提供,2022 年 4 月]

Enables ADP-ribosylglutamate hydrolase activity and deacetylase activity. Involved in cellular response to DNA damage stimulus; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MACROD1 基因产物(2)

mRNA Protein Name
NM_001411019.1 NP_001397948.1 ADP-ribose glycohydrolase MACROD1 isoform 2
NM_014067.4 NP_054786.2 ADP-ribose glycohydrolase MACROD1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ADP-ribosylglutamate hydrolase activity IDA
IDA: 通过直接分析推断
23474714 GOA
enables deacetylase activity IDA
IDA: 通过直接分析推断
21257746 GOA
enables hydrolase activity, acting on glycosyl bonds IDA
IDA: 通过直接分析推断
23474712 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17914104 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
23474712 GOA
involved in peptidyl-glutamate ADP-deribosylation IDA
IDA: 通过直接分析推断
23474714 GOA
involved in protein de-ADP-ribosylation IDA
IDA: 通过直接分析推断
23474712 GOA
involved in purine nucleoside metabolic process IDA
IDA: 通过直接分析推断
21257746 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
23474712 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MACROD1 蛋白结构

Macro

Macro: Macro domain (170 - 282)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
蛋白主名 其他名称

ADP-ribose glycohydrolase MACROD1

MACRO domain containing 1

MACROD1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MACROD1 Q9BQ69 KRT18 Homo sapiens P05783
Anti Bait CoIP
20035625
Intra MACROD1 Q9BQ69 KRT18 Homo sapiens P05783
Y2H
20035625
Intra MACROD1 Q9BQ69 KRT18 Homo sapiens P05783
Pull Down
20035625
Intra MACROD1 Q9BQ69 PARP1 Homo sapiens P09874
Anti Tag CoIP
33961781
Intra MACROD1 Q9BQ69 PARP1 Homo sapiens P09874
Anti Tag CoIP
28514442
Intra MACROD1 Q9BQ69 KPNA1 Homo sapiens P52294
Y2H Prey Pooling
32296183
Intra MACROD1 Q9BQ69 KPNA1 Homo sapiens P52294
Y2H Array
32296183
Intra MACROD1 Q9BQ69 RELA Homo sapiens Q04206
Pull Down
21483817
Intra MACROD1 Q9BQ69 ESR1 Homo sapiens P03372
Anti Bait CoIP
17914104
Intra MACROD1 Q9BQ69 ESR1 Homo sapiens P03372
Pull Down
17914104
Intra MACROD1 Q9BQ69 ESR1 Homo sapiens P03372
Anti Bait CoIP
20035625
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Cardiomyopathy, Dilated, 1e

Left Ventricular Noncompaction 9

Left Ventricular Noncompaction 5

Dilated Cardiomyopathy 1e

Dilated Cardiomyopathy 1s

CMD1E

Cdcd2

Cardiomyopathy, Dilated, 1y

CMD1Y

Cardiomyopathy, Dilated, 1s

CMD1S

Dilated Cardiomyopathy 1y

Dilated Cardiomyopathy With Conduction Defect 2

Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia

Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia

Cardiomyopathy, Dilated, With Conduction Defect 2

Cardiomyopathy Dilated With Conduction Defect Type 2

Cardiomyopathy, Dilated 1e

Cardiomyopathy, Dilated 1s

Cardiomyopathy, Dilated 1y

Left Ventricular Non-Compaction 5

LVNC5

Left Ventricular Non-Compaction 9

LVNC9

Cardiomyopathy, Dilated, Type 1e

Cardiomyopathy, Dilated, Type 1s

Cardiomyopathy, Dilated, Type 1y

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MACROD1 VGNC VGNC:107456
Bos taurus MACROD1 VGNC VGNC:56272
Mus musculus MACROD1 MGD MGI:2147583
Felis catus MACROD1 VGNC VGNC:103132
Canis familiaris MACROD1 VGNC VGNC:51880
Rattus norvegicus MACROD1 RGD RGD:628701