2. Gene
  3. CHERP - calcium homeostasis endoplasmic reticulum protein Gene

CHERP - calcium homeostasis endoplasmic reticulum protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钙稳态内质网蛋白

种属: Homo sapiens

同用名: SRA1; DAN16; SCAF6

基因 ID: 10523 | 基因类型: protein coding

关于 CHERP

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,517,894-16,542,437 (from NCBI)

This gene has 7 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in testis (RPKM 13.3), spleen (RPKM 10.7) and 25 other tissues.

功能概要

启用跨膜转运蛋白结合活动。参与钙调神经磷酸酶-NFAT 信号级联的正向调节和将螯合的钙离子释放到胞质溶胶中。在细胞钙离子稳态和细胞群增殖的负调节的上游或内部起作用。位于细胞质的核周区。 [由基因组资源联盟提供，2022 年 4 月]

Enables transmembrane transporter binding activity. Involved in positive regulation of calcineurin-NFAT signaling cascade and release of sequestered calcium ion into cytosol. Acts upstream of or within cellular calcium ion homeostasis and negative regulation of cell population proliferation. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CHERP 基因产物(1)

mRNA Protein Name
NM_006387.6 NP_006378.3 calcium homeostasis endoplasmic reticulum protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22365833 GOA
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
21454501 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: 通过直接分析推断
10794731 GOA
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
10794731 GOA
involved in positive regulation of calcineurin-NFAT signaling cascade IMP
IMP: 通过突变表型推断
12656674 GOA
involved in release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
12656674 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10794731 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
12656674 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHERP 蛋白结构

Surp

Surp: Surp module (13 - 61)

CTD_bind

CTD_bind: RNA polymerase II-binding domain. (211 - 274)

G-patch

G-patch: G-patch domain (842 - 888)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 916 a.a.
蛋白主名 其他名称

calcium homeostasis endoplasmic reticulum protein

ERPROT 213-21

CHERP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CHERP Q8IWX8 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra CHERP Q8IWX8 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra CHERP Q8IWX8 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra CHERP Q8IWX8 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra CHERP Q8IWX8 RBFOX2 Homo sapiens O43251-10
Y2H Array
32296183
Intra CHERP Q8IWX8 RBFOX2 Homo sapiens O43251-10
Y2H Prey Pooling
32296183
Intra CHERP Q8IWX8 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra CHERP Q8IWX8 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra CHERP Q8IWX8 TLE3 Homo sapiens Q04726-4
Y2H Prey Pooling
32296183
Intra CHERP Q8IWX8 TLE3 Homo sapiens Q04726-4
Y2H Array
32296183
Intra CHERP Q8IWX8 FIGN Homo sapiens Q5HY92
Y2H Prey Pooling
32296183
Intra CHERP Q8IWX8 FIGN Homo sapiens Q5HY92
Y2H Array
32296183
Intra CHERP Q8IWX8 FASTK Homo sapiens Q14296
Y2H Array
32296183
Intra CHERP Q8IWX8 FASTK Homo sapiens Q14296
Y2H Prey Pooling
32296183
Intra CHERP Q8IWX8 DHX8 Homo sapiens Q14562
Y2H
22365833
Intra CHERP Q8IWX8 SNRNP27 Homo sapiens Q8WVK2
Y2H
22365833
Intra CHERP Q8IWX8 SAXO1 Homo sapiens Q8IYX7
Y2H Array
32296183
Intra CHERP Q8IWX8 SAXO1 Homo sapiens Q8IYX7
Y2H Prey Pooling
32296183
Intra CHERP Q8IWX8 SAXO1 Homo sapiens Q8IYX7
Validated Y2H
32296183
Intra CHERP Q8IWX8 LUC7L Homo sapiens Q9NQ29
Anti Tag CoIP
22365833
Intra CHERP Q8IWX8 LUC7L Homo sapiens Q9NQ29
Y2H
22365833
Intra CHERP Q8IWX8 FRA10AC1 Homo sapiens Q70Z53
Anti Tag CoIP
22365833
Intra CHERP Q8IWX8 FRA10AC1 Homo sapiens Q70Z53
Y2H
22365833
Intra CHERP Q8IWX8 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra CHERP Q8IWX8 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra CHERP Q8IWX8 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra CHERP Q8IWX8 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra CHERP Q8IWX8 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra CHERP Q8IWX8 U2AF2 Homo sapiens P26368
Anti Tag CoIP
22365833
Intra CHERP Q8IWX8 SF1 Homo sapiens Q15637
Pull Down
26420826
Intra CHERP Q8IWX8 CLK3 Homo sapiens P49761
Y2H Prey Pooling
32296183
Intra CHERP Q8IWX8 CLK3 Homo sapiens P49761
Validated Y2H
32296183
Intra CHERP Q8IWX8 CLK3 Homo sapiens P49761
Y2H Array
32296183
Intra CHERP Q8IWX8 LASP1 Homo sapiens Q14847-2
Y2H Array
32296183
Intra CHERP Q8IWX8 LASP1 Homo sapiens Q14847-2
Y2H Prey Pooling
32296183
Intra CHERP Q8IWX8 C1orf94 Homo sapiens Q6P1W5
Y2H Array
32296183
Intra CHERP Q8IWX8 C1orf94 Homo sapiens Q6P1W5
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 7

Spinocerebellar Ataxia Type 7

SCA7

Opca3

Opca Iii

Olivopontocerebellar Atrophy Iii

Opca With Retinal Degeneration

Opca With Macular Degeneration And External Ophthalmoplegia

Adca, Type Ii

Autosomal Dominant Cerebellar Ataxia Type 2

Olivopontocerebellar Atrophy 3

Autosomal Dominant Cerebellar Ataxia, Type Ii

Autosomal Dominant Cerebellar Ataxia Type Ii

Adca2

Adcaii

Ataxia With Pigmentary Retinopathy

Cerebellar Syndrome-Pigmentary Maculopathy Syndrome

Olivopontocerebellar Atrophy With Retinal Degeneration

Spinocerebellar Ataxia-7

Ataxia, Spinocerebellar, Type 7
Primary Cerebellar Degeneration

Spinocerebellar Degenerations

Cerebellar Degenerations, Primary

Spinocerebellar Degeneration
Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1

SCA1

Olivopontocerebellar Atrophy I

Opca1

Opca4

Menzel Type Opca

Schut-Haymaker Type Opca

Spinocerebellar Atrophy I

Opca I

Olivopontocerebellar Atrophy Iv

Opca Iv

Cerebelloparenchymal Disorder I

Cpd1

Olivopontocerebellar Atrophy 1

Cerebelloparenchymal Disorder 1

Olivopontocerebellar Atrophy 4

Spinocerebellar Atrophy 1

Type 1 Spinocerebellar Ataxia

Spinocerebellar Ataxia-1

Ataxia, Spinocerebellar, Type 1
Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar
Pancreatic Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Pancreas

Adenosquamous Carcinoma Of The Pancreas
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02622 CHERP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CHERP VGNC VGNC:39210
Bos taurus CHERP VGNC VGNC:27287
Rattus norvegicus CHERP RGD RGD:1305279
Felis catus CHERP VGNC VGNC:60852
Mus musculus CHERP MGD MGI:106417
Macaca mulatta CHERP VGNC VGNC:70960
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