FASTK - Fas activated serine/threonine kinase Gene

中文名称：Fas 激活的丝氨酸/苏氨酸激酶

种属: Homo sapiens

同用名: FAST

关于 FASTK

功能概要

该基因编码的蛋白质是丝氨酸/苏氨酸蛋白激酶家族的成员。该激酶显示在 Jurkat 细胞中 Fas 介导的细胞凋亡过程中被快速激活。响应于 Fas 受体连接，它磷酸化 TIA1，一种促进细胞凋亡的核 RNA 结合蛋白。编码的蛋白质是淋巴细胞凋亡的强诱导剂。已发现该基因的两个转录本变体编码不同的亚型。存在其他变体，但尚未确定其全长性质。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated Apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte Apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]