U2AF2 - U2 small nuclear RNA auxiliary factor 2 Gene

中文名称：U2 小核 RNA 辅助因子 2

种属: Homo sapiens

同用名: U2AF65

关于 U2AF2

功能概要

U2 辅助因子 (U2AF) 由一个大亚基和一个小亚基组成，是 U2 snRNP 与 pre-mRNA 分支位点结合所需的非 snRNP 蛋白。该基因编码 U2AF 大亚基，该亚基包含一个具有 3 个 RNA 识别基序的序列特异性 RNA 结合区和一个剪接所需的富含 Arg/Ser 的结构域。在剪接体组装的早期，大亚基与内含子的聚嘧啶束结合。已检测到该基因的多个转录变体，但迄今为止仅确定了两个的全长性质。[RefSeq 提供，2008 年 7 月]

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]