RBM10 - RNA binding motif protein 10 Gene

中文名称：RNA 结合基序蛋白 10

种属: Homo sapiens

同用名: S1-1; TARPS; GPATC9; ZRANB5; GPATCH9; DXS8237E; MINAS-60

基因 ID: 8241 | 基因类型: protein coding

关于 RBM10

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:47,145,221-47,186,813 (from NCBI)

This gene has 6 transcripts (splice variants), 186 orthologues, 2 paralogues and is associated with 102 phenotypes. Ubiquitous expression in ovary (RPKM 15.6), spleen (RPKM 12.3) and 25 other tissues.

功能概要

该基因编码的核蛋白属于含有 RNA 结合基序的蛋白质家族。编码的蛋白质与 hnRNP 蛋白质相关联，可能参与调节选择性剪接。该基因的缺陷是 X 连锁隐性疾病 TARP 综合征的病因。交替剪接导致多个转录变体。[RefSeq 提供，2011 年 3 月]

This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]

RBM10 基因产物(5)

mRNA	Protein	Name
NM_001204466.2	NP_001191395.1	RNA-binding protein 10 isoform 3
NM_001204467.2	NP_001191396.1	RNA-binding protein 10 isoform 4
NM_001204468.2	NP_001191397.1	RNA-binding protein 10 isoform 5
NM_005676.5	NP_005667.2	RNA-binding protein 10 isoform 1
NM_152856.3	NP_690595.1	RNA-binding protein 10 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	22365833	GOA
enables miRNA binding	IDA IDA: 通过直接分析推断	28431233	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	22365833	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of ribosomal large subunit export from nucleus	IDA IDA: 通过直接分析推断	35393574	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in nucleolus	IDA IDA: 通过直接分析推断	35393574	GOA
located in nucleus	IDA IDA: 通过直接分析推断	28091594	GOA
part of protein-containing complex	IPI IPI: 通过物理相互作用推断	17707232	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RBM10 蛋白结构

zf-RanBP

G-patch

0
200
400
600
800
930 a.a.

蛋白主名

其他名称

RNA-binding protein 10

G-patch domain containing 9

RBM10 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RBM10	P98175	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	32296183
种属内	RBM10	P98175	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	32296183
种属内	RBM10	P98175	SF3A1	Homo sapiens	Q15459	Anti Tag CoIP	22365833
种属内	RBM10	P98175	PATZ1	Homo sapiens	Q9HBE1-4	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	PATZ1	Homo sapiens	Q9HBE1-4	Validated Y2H	32296183
种属内	RBM10	P98175	PATZ1	Homo sapiens	Q9HBE1-4	Y2H Array	32296183
种属内	RBM10	P98175	ZNF526	Homo sapiens	Q8TF50	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	ZNF526	Homo sapiens	Q8TF50	Validated Y2H	32296183
种属内	RBM10	P98175	ZNF526	Homo sapiens	Q8TF50	Y2H Array	32296183
种属内	RBM10	P98175	CPSF7	Homo sapiens	Q8N684-3	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	CPSF7	Homo sapiens	Q8N684-3	Validated Y2H	26871637
种属内	RBM10	P98175	CPSF7	Homo sapiens	Q8N684-3	Validated Y2H	32296183
种属内	RBM10	P98175	CPSF7	Homo sapiens	Q8N684-3	Y2H Array	26871637
种属内	RBM10	P98175	CPSF7	Homo sapiens	Q8N684-3	Y2H Array	32296183
种属内	RBM10	P98175	CPSF7	Homo sapiens	Q8N684-3	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	ZNF317	Homo sapiens	Q96PQ6	Validated Y2H	32296183
种属内	RBM10	P98175	ZNF317	Homo sapiens	Q96PQ6	Y2H Array	32296183
种属内	RBM10	P98175	ZNF317	Homo sapiens	Q96PQ6	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	PTBP2	Homo sapiens	Q9UKA9-2	Validated Y2H	26871637
种属内	RBM10	P98175	PTBP2	Homo sapiens	Q9UKA9-2	Y2H Array	26871637
种属内	RBM10	P98175	PTBP2	Homo sapiens	Q9UKA9-2	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	DHX15	Homo sapiens	O43143	Y2H	22365833
种属内	RBM10	P98175	DHX15	Homo sapiens	O43143	Anti Tag CoIP	22365833
种属内	RBM10	P98175	PRR20E	Homo sapiens	P86478	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	PRR20E	Homo sapiens	P86478	Validated Y2H	26871637
种属内	RBM10	P98175	PRR20E	Homo sapiens	P86478	Y2H Array	26871637
种属内	RBM10	P98175	PTBP1	Homo sapiens	P26599-3	Validated Y2H	26871637
种属内	RBM10	P98175	PTBP1	Homo sapiens	P26599-3	Y2H Array	26871637
种属内	RBM10	P98175	PTBP1	Homo sapiens	P26599-3	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	26871637
种属内	RBM10	P98175	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	26871637
种属内	RBM10	P98175	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	ZNF275	Homo sapiens	Q9NSD4	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	ZNF275	Homo sapiens	Q9NSD4	Validated Y2H	32296183
种属内	RBM10	P98175	ZNF275	Homo sapiens	Q9NSD4	Y2H Array	32296183
种属内	RBM10	P98175	SUGP1	Homo sapiens	Q8IWZ8	Y2H	22365833
种属内	RBM10	P98175	CBLL1	Homo sapiens	Q75N03	Validated Y2H	26871637
种属内	RBM10	P98175	CBLL1	Homo sapiens	Q75N03	Y2H Array	26871637
种属内	RBM10	P98175	CBLL1	Homo sapiens	Q75N03	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	U2SURP	Homo sapiens	O15042	Anti Tag CoIP	22365833
种属内	RBM10	P98175	U2SURP	Homo sapiens	O15042	Y2H	22365833
种属内	RBM10	P98175	ZNF408	Homo sapiens	Q9H9D4	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	ZNF408	Homo sapiens	Q9H9D4	Validated Y2H	32296183
种属内	RBM10	P98175	ZNF408	Homo sapiens	Q9H9D4	Y2H Array	32296183
种属内	RBM10	P98175	SF3B4	Homo sapiens	Q15427	Y2H	22365833
种属内	RBM10	P98175	SF3B4	Homo sapiens	Q15427	Validated Y2H	26871637
种属内	RBM10	P98175	SF3B4	Homo sapiens	Q15427	Validated Y2H	32296183
种属内	RBM10	P98175	SF3B4	Homo sapiens	Q15427	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	SF3B4	Homo sapiens	Q15427	Y2H Array	26871637
种属内	RBM10	P98175	SF3B4	Homo sapiens	Q15427	Y2H Array	32296183
种属内	RBM10	P98175	SF3B4	Homo sapiens	Q15427	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	PTBP1	Homo sapiens	P26599	Validated Y2H	26871637
种属内	RBM10	P98175	PTBP1	Homo sapiens	P26599	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	PTBP1	Homo sapiens	P26599	Y2H Array	26871637
种属内	RBM10	P98175	CCAR1	Homo sapiens	Q8IX12	Y2H	22365833
种属内	RBM10	P98175	CCAR1	Homo sapiens	Q8IX12	Anti Tag CoIP	35271311
种属内	RBM10	P98175	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
种属内	RBM10	P98175	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
种属内	RBM10	P98175	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
种属内	RBM10	P98175	PRPF19	Homo sapiens	Q9UMS4	Anti Tag CoIP	22365833
种属内	RBM10	P98175	PRPF19	Homo sapiens	Q9UMS4	Y2H	22365833
种属内	RBM10	P98175	PRDM14	Homo sapiens	Q9GZV8	Validated Y2H	26871637
种属内	RBM10	P98175	PRDM14	Homo sapiens	Q9GZV8	Validated Y2H	32296183
种属内	RBM10	P98175	PRDM14	Homo sapiens	Q9GZV8	Y2H Array	26871637
种属内	RBM10	P98175	PRDM14	Homo sapiens	Q9GZV8	Y2H Array	32296183
种属内	RBM10	P98175	PRDM14	Homo sapiens	Q9GZV8	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	PRDM14	Homo sapiens	Q9GZV8	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	ZFP64	Homo sapiens	Q9NTW7	Y2H Array	26871637
种属内	RBM10	P98175	ZFP64	Homo sapiens	Q9NTW7	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	ZFP64	Homo sapiens	Q9NTW7	Validated Y2H	26871637
种属内	RBM10	P98175	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
种属内	RBM10	P98175	MBD6	Homo sapiens	Q96DN6	Validated Y2H	32296183
种属内	RBM10	P98175	MBD6	Homo sapiens	Q96DN6	Y2H Array	32296183
种属内	RBM10	P98175	MBD6	Homo sapiens	Q96DN6	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	ccsb orf id: 2129	Homo sapiens	EBI-16432778	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	ccsb orf id: 2129	Homo sapiens	EBI-16432778	Validated Y2H	26871637
种属内	RBM10	P98175	ccsb orf id: 2129	Homo sapiens	EBI-16432778	Y2H Array	26871637
种属内	RBM10	P98175	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	ccsb orf id: 2129	Homo sapiens	EBI-16432778	Y2H Array	32296183
种属内	RBM10	P98175	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	26871637
种属内	RBM10	P98175	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
种属内	RBM10	P98175	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	26871637
种属内	RBM10	P98175	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
种属内	RBM10	P98175	ccsb orf id: 2129	Homo sapiens	EBI-16432778	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	26871637
种属内	RBM10	P98175	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
种属内	RBM10	P98175	THAP1	Homo sapiens	Q9NVV9	Y2H Array	26871637
种属内	RBM10	P98175	THAP1	Homo sapiens	Q9NVV9	Y2H Array	32296183
种属内	RBM10	P98175	U2AF2	Homo sapiens	P26368	Y2H	22365833
种属内	RBM10	P98175	BAHD1	Homo sapiens	Q8TBE0	Validated Y2H	32296183
种属内	RBM10	P98175	BAHD1	Homo sapiens	Q8TBE0	Y2H Array	32296183
种属内	RBM10	P98175	BAHD1	Homo sapiens	Q8TBE0	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	KHDRBS2	Homo sapiens	Q5VWX1	Validated Y2H	26871637
种属内	RBM10	P98175	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	26871637
种属内	RBM10	P98175	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	ZBTB24	Homo sapiens	O43167	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	ZBTB24	Homo sapiens	O43167	Validated Y2H	26871637
种属内	RBM10	P98175	ZBTB24	Homo sapiens	O43167	Y2H Array	26871637
种属内	RBM10	P98175	DDX17	Homo sapiens	Q92841	Validated Y2H	26871637
种属内	RBM10	P98175	DDX17	Homo sapiens	Q92841	Validated Y2H	32296183
种属内	RBM10	P98175	DDX17	Homo sapiens	Q92841	Y2H Array	26871637
种属内	RBM10	P98175	DDX17	Homo sapiens	Q92841	Y2H Array	32296183
种属内	RBM10	P98175	DDX17	Homo sapiens	Q92841	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	DDX17	Homo sapiens	Q92841	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	GPKOW	Homo sapiens	Q92917	Y2H	22365833
种属内	RBM10	P98175	ZNF473	Homo sapiens	Q8WTR7	Validated Y2H	26871637
种属内	RBM10	P98175	ZNF473	Homo sapiens	Q8WTR7	Y2H Array	26871637
种属内	RBM10	P98175	ZNF473	Homo sapiens	Q8WTR7	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	SNRPC	Homo sapiens	P09234	Y2H	22365833
种属内	RBM10	P98175	KLF1	Homo sapiens	Q13351	Y2H Prey Pooling	32296183
种属内	RBM10	P98175	KLF1	Homo sapiens	Q13351	Validated Y2H	32296183
种属内	RBM10	P98175	KLF1	Homo sapiens	Q13351	Y2H Array	32296183
种属内	RBM10	P98175	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	26871637
种属内	RBM10	P98175	RBMY1F	Homo sapiens	Q15415	Validated Y2H	26871637
种属内	RBM10	P98175	RBMY1F	Homo sapiens	Q15415	Y2H Array	26871637
种属内	RBM10	P98175	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Tarp Syndrome

TARPS	Pierre Robin Syndrome With Congenital Heart Malformation And Clubfoot
Pierre Robin Sequence-Congenital Heart Defect-Talipes Syndrome	Pierre Robin Syndrome-Congenital Heart Defect-Talipes Syndrome
Talipes Equinovarus-Atrial Septal Defect-Robin Sequence-Persistence Of The Left Superior Vena Cava Syndrome	Talipes Equinovarus, Atrial Septal Defect, Robin Sequence, And Persistence Of Left Superior Vena Cava
Pierre Robin Sequence - Congenital Heart Defect - Talipes	Pierre Robin Syndrome - Congenital Heart Defect - Talipes
Talipes Equinovarus - Atrial Septal Defect - Robin Sequence - Persistence Of The Left Superior Vena Cava	Talipes Equinovarus Atrial Septal Defect Robin Sequence And Persistence Of Left Superior Vena Cava

Pierre Robin Syndrome

Pierre Robin Sequence	Glossoptosis, Micrognathia, And Cleft Palate
Pierre Robin Syndrome Skeletal Dysplasia Polydactyly	Pierre-Robin Syndrome
Isolated Pierre Robin Sequence	Isolated Pierre-Robin Syndrome
PRBNS	Robin Sequence
Robin Syndrome	Isolated Pierre Robin Syndrome

Skin Angiosarcoma

Angiosarcoma Of Skin	Hemangiosarcoma Of The Skin
Haemangiosarcoma Of Skin	Lymphangiosarcoma Of Skin
Cutaneous Angiosarcoma	Malignant Haemangioendothelioma Of Skin

Talipes Equinovarus

Congenital Equinovarus	Congenital Talipes Equinovarus
Equinovarus	Congenital Varus Clubfoot

Treacher Collins Syndrome 1

Treacher Collins Syndrome	Mandibulofacial Dysostosis
Treacher Collins-Franceschetti Syndrome	Tcof
Tcs	Mfd1
Franceschetti-Klein Syndrome	TCS1
Franceschetti Syndrome	Franceschetti-Zwahlen-Klein Syndrome
Zygoauromandibular Dysplasia	Treacher-Collins Syndrome
Mandibulofacial Dysostosis Without Limb Anomalies	Bilateral And Symmetric Oto-Mandibular Dysplasia

Atrial Heart Septal Defect

Atrial Septal Defect	Atrial Septal Defects
Atrioseptal Defect	Auricular Septal Defect
Congenital Atrial Septal Defect	Interatrial Septal Defect
Interauricular Septal Defect	Heart Septal Defects, Atrial
Septal Defect, Atrial

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma	Hereditary Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma, Sporadic	Papillary Renal Cell Adenocarcinoma
RCCP	RCCP1
Renal Cell Carcinoma, Papillary	Renal Cell Carcinoma, Papillary, 1, Familial And Somatic
Chromophil Carcinoma Of Kidney	Papillary Kidney Carcinoma
Sporadic Papillary Renal Cell Carcinoma	Chromophil Renal Cell Carcinoma
Papillary Renal Carcinoma, Malignant -	Papillary Renal Cell Carcinoma, Bilateral -
Papillary Renal Cell Carcinoma, Familial -	Papillary Renal Cell Carcinoma, Multiple -
Papillary Renal Cell Carcinoma, Sporadic -	Renal Adenocarcinoma
Chromophil Rcc	Hprcc
Renal Cell Carcinoma Papillary	Chromophilic Renal Cell Carcinoma
Prcc	Carcinoma, Renal Cell, Papillary, Type 1
Type 1 Papillary Renal Cell Carcinoma	Renal Cell Carcinoma
Hereditary Papillary Renal Carcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-142032	RBM10-8	Inhibitor	/	否
HY-RS11731	RBM10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	RBM10	VGNC	VGNC:33783
Macaca mulatta	RBM10	VGNC	VGNC:76680
Felis catus	RBM10	VGNC	VGNC:69262
Mus musculus	RBM10	MGD	MGI:2384310
Rattus norvegicus	RBM10	RGD	RGD:631366
Canis familiaris	RBM10	VGNC	VGNC:45404

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RBM10 - RNA binding motif protein 10 Gene

关于 RBM10

功能概要

RBM10 基因产物(5)

RBM10 蛋白结构

RBM10 蛋白互作信息

关联疾病

直系同源

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RBM10 - RNA binding motif protein 10 Gene

关于 RBM10

功能概要

RBM10 基因产物(5)

RBM10 蛋白结构

RBM10 蛋白互作信息

关联疾病

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