DDX17 - DEAD-box helicase 17 Gene

中文名称：死盒解旋酶 17

种属: Homo sapiens

同用名: P72; RH70

关于 DDX17

功能概要

以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。它们涉及许多涉及 RNA 二级结构改变的细胞过程，例如翻译起始、核和线粒体剪接以及核糖体和剪接体组装。根据它们的分布模式，该家族的一些成员被认为参与了胚胎发生、精子发生以及细胞生长和分裂。该基因编码一个 DEAD box 蛋白，它是一种被多种 RNA 激活的 ATP 酶，但不被 dsDNA 激活。这种蛋白质以及由 DDX5 基因编码的蛋白质彼此之间的关系比与 DEAD 盒家族的任何其他成员之间的关系更为密切。由于选择性剪接和使用替代翻译起始密码子，包括非 AUG (CUG) 起始密码子，该基因可以编码多种亚型。[RefSeq 提供，2011 年 4 月]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]