2. Gene
  3. RBM15 - RNA binding motif protein 15 Gene

RBM15 - RNA binding motif protein 15 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RNA 结合基序蛋白 15

种属: Homo sapiens

同用名: OTT; OTT1; SPEN

基因 ID: 64783 | 基因类型: protein coding

关于 RBM15

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,339,377-110,346,677 (from NCBI)

This gene has 9 transcripts (splice variants), 259 orthologues, 7 paralogues and is associated with 58 phenotypes. Broad expression in bone marrow (RPKM 6.3), testis (RPKM 2.8) and 24 other tissues.

功能概要

SPEN (Split-end) 蛋白家族的成员，包括 RBM15，在多个信号通路中具有抑制功能，并可能通过与剪接体成分的相互作用与 RNA 结合 (Hiriart 等人，2005 [PubMed 16129689]) 。[OMIM 提供, 2009 年 2 月]

Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

RBM15 基因产物(2)

mRNA Protein Name
NM_001201545.2 NP_001188474.1 RNA-binding protein 15 isoform 2
NM_022768.5 NP_073605.4 RNA-binding protein 15 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
27602518 GOA
enables mRNA binding IDA
IDA: 通过直接分析推断
26575292 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16129689 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RNA methylation IDA
IDA: 通过直接分析推断
27602518 GOA
involved in dosage compensation by inactivation of X chromosome IDA
IDA: 通过直接分析推断
27602518 GOA
NOT involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16129689 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
26575292 GOA
involved in regulation of megakaryocyte differentiation IDA
IDA: 通过直接分析推断
26575292 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA N6-methyladenosine methyltransferase complex IDA
IDA: 通过直接分析推断
27602518 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
24100041 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
24100041 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RBM15 蛋白结构

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (190 - 248)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (376 - 444)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (471 - 527)

SPOC

SPOC: SPOC domain (788 - 924)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 977 a.a.
蛋白主名 其他名称

RNA-binding protein 15

one twenty two protein

RBM15 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RBM15 Q96T37 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
种属内
RBM15 Q96T37 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
种属内
RBM15 Q96T37 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
种属内
RBM15 Q96T37 NAV2 Homo sapiens Q8IVL1
Validated Y2H
25416956
种属内
RBM15 Q96T37 NAV2 Homo sapiens Q8IVL1
Y2H Prey Pooling
25416956
种属内
RBM15 Q96T37 CEP44 Homo sapiens Q9C0F1
Validated Y2H
25416956
种属内
RBM15 Q96T37 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
25416956
种属内
RBM15 Q96T37 CEP44 Homo sapiens Q9C0F1
Y2H Array
25416956
种属内
RBM15 Q96T37 DDX17 Homo sapiens Q92841
Y2H Array
25416956
种属内
RBM15 Q96T37 DDX17 Homo sapiens Q92841
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Megakaryoblastic Acute Myeloid Leukemia With T(1;22)(P13;Q13)

Megakaryoblastic Aml With T(1

22)(P13

Q13)
Acute Megakaryocytic Leukemia

Acute Megakaryoblastic Leukemia

Acute Megakaryoblastic Leukaemia

Megakaryocytic Myelosis

Thrombocytic Leukaemia

Amkl

Aml M7

Acute Myeloblastic Leukemia Type 7

Acute Myeloid Leukemia M7

Megakaryoblastic Leukemia Acute

Leukemia, Megakaryoblastic, Acute

Acute Myeloid Leukaemia, M7

Acute Megakaryocytic Leukaemia

Acute Megakaryoblastic Leukaemia, Fab M7

Fab M7

Malignant Megakaryocytosis

M7 - Acute Megakaryoblastic Leukaemia

Megakaryoblastic Leukaemia

Megakaryocytic Leukaemia

Acute Megakaryoblastic Leukaemia, Nos

Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Neonatal Leukemia
Myeloproliferative Syndrome, Transient

Transient Abnormal Myelopoiesis

Transient Myeloproliferative Syndrome

Transient Myeloproliferative Disease

Mst

Tam

Leukemia, Transient, Of Down Syndrome

Tmd

Leukemia, Transient

Transient Leukemia

Transient Leukemia Of Down Syndrome
Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome

Deletion 1p36

Monosomy 1p36

Subtelomeric 1p36 Deletion

Monosomy 1p36 Syndrome

Distal Monosomy 1p36

Del(1)(P36)

Deletion 1pter

Monosomy 1pter
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11735 RBM15 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11736 RBM15B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RBM15 RGD RGD:1592713
Felis catus RBM15 VGNC VGNC:64521
Macaca mulatta RBM15 VGNC VGNC:76481
Mus musculus RBM15 MGD MGI:2443205
Canis familiaris RBM15 VGNC VGNC:45409
Bos taurus RBM15 VGNC VGNC:33787
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