2. Gene
  3. NAV2 - neuron navigator 2 Gene

NAV2 - neuron navigator 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经元导航器 2

种属: Homo sapiens

同用名: HELAD1; RAINB1; POMFIL2; UNC53H2; STEERIN2

基因 ID: 89797 | 基因类型: protein coding

关于 NAV2

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:19,345,236-20,121,601 (from NCBI)

This gene has 15 transcripts (splice variants), 242 orthologues and 2 paralogues. Broad expression in thyroid (RPKM 4.0), brain (RPKM 3.3) and 25 other tissues.

功能概要

该基因编码神经元导航基因家族的一个成员，可能在细胞生长和迁移中发挥作用。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 10 月]

This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

NAV2 基因产物(5)

mRNA Protein Name
NM_001111018.2 NP_001104488.1 neuron navigator 2 isoform 3
NM_001111019.3 NP_001104489.1 neuron navigator 2 isoform 4
NM_001244963.2 NP_001231892.1 neuron navigator 2 isoform 5
NM_145117.5 NP_660093.2 neuron navigator 2 isoform 2
NM_182964.6 NP_892009.3 neuron navigator 2 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3'-5' DNA helicase activity IDA
IDA: 通过直接分析推断
12214280 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NAV2 蛋白结构

CH

CH: Calponin homology (CH) domain (91 - 190)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2488 a.a.
蛋白主名 其他名称

neuron navigator 2

helicase, APC down-regulated 1

NAV2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NAV2 Q8IVL1 CFAP58 Homo sapiens Q5T655
Y2H Array
25416956
种属内
NAV2 Q8IVL1 RBM15B Homo sapiens Q8NDT2-2
Y2H Array
25416956
种属内
NAV2 Q8IVL1 RBM15B Homo sapiens Q8NDT2-2
Y2H Prey Pooling
25416956
种属内
NAV2 Q8IVL1 RBM15 Homo sapiens Q96T37
Y2H Array
25416956
种属内
NAV2 Q8IVL1 ADAT2 Homo sapiens Q7Z6V5
Y2H Prey Pooling
25416956
种属内
NAV2 Q8IVL1 ADAT2 Homo sapiens Q7Z6V5
Validated Y2H
25416956
种属内
NAV2 Q8IVL1 ADAT2 Homo sapiens Q7Z6V5
Y2H Array
25416956
种属内
NAV2 Q8IVL1 ING4 Homo sapiens Q9UNL4
Y2H Array
25416956
种属内
NAV2 Q8IVL1 ING4 Homo sapiens Q9UNL4
Validated Y2H
25416956
种属内
NAV2 Q8IVL1 PIAS2 Homo sapiens O75928
Y2H Array
25416956
种属内
NAV2 Q8IVL1 MORF4L1 Homo sapiens Q9UBU8
Y2H Prey Pooling
25416956
种属内
NAV2 Q8IVL1 MORF4L1 Homo sapiens Q9UBU8
Y2H Array
25416956
种属内
NAV2 Q8IVL1 ING5 Homo sapiens Q8WYH8
Validated Y2H
25416956
种属内
NAV2 Q8IVL1 RBM15B Homo sapiens Q8NDT2
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Neuroblastoma 1

Neuroblastoma, Susceptibility To, 1

NBLST1

Neuroblastoma, Susceptibility To, Type 1
Sucrase-Isomaltase Deficiency, Congenital

Congenital Sucrase-Isomaltase Deficiency

CSID

Si Deficiency

Congenital Sucrose Intolerance

Disaccharide Intolerance

Sucrase-Isomaltase Deficiency

Disaccharide Intolerance I

Congenital Sucrose-Isomaltose Malabsorption

Sucrose-Isomaltose Malabsorption, Congenital

Sucrose Intolerance, Congenital

Congenital Sucrase-Isomaltose Malabsorption

Congenital Sucrose-Isomaltase Malabsorption

Disaccharide Intolerance, 1

Sucrose Intolerance Congenital

Sucrose-Isomaltase Malabsorption, Congenital

Disaccharidase Deficiency

Invertase Deficiency

Sucrase-Alpha-Dextrinase Deficiency

Disaccharide Intolerance Type I

Csid - [Congenital Sucrase-Isomaltase Deficiency]

Sucrose Intolerance Of Newborn

Sucrose Intolerance

Sucrase Deficiency

Disaccharide Malabsorption

Intestinal Disaccharidase Deficiency
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09047 NAV2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NAV2 VGNC VGNC:74968
Felis catus NAV2 VGNC VGNC:81976
Bos taurus NAV2 VGNC VGNC:31891
Mus musculus NAV2 MGD MGI:2183691
Canis familiaris NAV2 VGNC VGNC:43630
Rattus norvegicus NAV2 RGD RGD:619778
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