ING5 - inhibitor of growth family member 5 Gene

中文名称：生长抑制因子家族成员 5

种属: Homo sapiens

同用名: p28ING5

基因 ID: 84289 | 基因类型: protein coding

关于 ING5

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,687,020-241,729,478 (from NCBI)

This gene has 13 transcripts (splice variants), 216 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 3.6), skin (RPKM 3.2) and 25 other tissues.

功能概要

该基因编码一种抑制细胞生长并诱导细胞凋亡的抑癌蛋白。这种蛋白质含有一个 PHD 型锌指。它与肿瘤抑制基因 p53 和 p300 (组蛋白乙酰转移酶复合物的一个组成部分) 相互作用，表明它在转录调控中发挥作用。可变剪接和使用多个启动子和 3' 末端外显子会导致多个转录变体。[RefSeq 提供，2016 年 8 月]

This gene encodes a tumor suppressor protein that inhibits cell growth and induces Apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]

ING5 基因产物(3)

mRNA	Protein	Name
NM_001330161.2	NP_001317090.1	inhibitor of growth protein 5 isoform 2
NM_001330162.2	NP_001317091.1	inhibitor of growth protein 5 isoform 3
NM_032329.6	NP_115705.2	inhibitor of growth protein 5 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables methylated histone binding	IDA IDA: 通过直接分析推断	16728974	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12750254	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA replication-dependent chromatin disassembly	IDA IDA: 通过直接分析推断	16387653	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	12750254	GOA
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: 通过遗传相互作用推断	21750715	GOA
involved in negative regulation of growth	IDA IDA: 通过直接分析推断	12750254	GOA
acts upstream of or within positive regulation of apoptotic process	IGI IGI: 通过遗传相互作用推断	21750715	GOA
involved in protein acetylation	IDA IDA: 通过直接分析推断	12750254	GOA
involved in regulation of DNA biosynthetic process	IDA IDA: 通过直接分析推断	16387653	GOA
involved in regulation of DNA replication	IDA IDA: 通过直接分析推断	16387653	GOA
involved in regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	18794358	GOA
involved in regulation of cell cycle	IDA IDA: 通过直接分析推断	16387653	GOA
involved in regulation of cell growth	IDA IDA: 通过直接分析推断	22144582	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MOZ/MORF histone acetyltransferase complex	IDA IDA: 通过直接分析推断	16387653	GOA
part of histone acetyltransferase complex	IDA IDA: 通过直接分析推断	16387653	GOA
part of histone acetyltransferase complex	IPI IPI: 通过物理相互作用推断	16387653	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	16387653	GOA
located in nucleus	IDA IDA: 通过直接分析推断	18794358	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ING5 蛋白结构

ING

PHD

0
100
200
240 a.a.

蛋白主名

其他名称

inhibitor of growth protein 5

ING5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ING5	Q8WYH8	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	ING5	Q8WYH8	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	ING5	Q8WYH8	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	ING5	Q8WYH8	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	32296183
Intra	ING5	Q8WYH8	MBIP	Homo sapiens	Q9NS73-5	Validated Y2H	25416956
Intra	ING5	Q8WYH8	MBIP	Homo sapiens	Q9NS73-5	Y2H Array	25416956
Intra	ING5	Q8WYH8	ICA1	Homo sapiens	Q05084	Y2H Prey Pooling	25416956
Intra	ING5	Q8WYH8	ICA1	Homo sapiens	Q05084	Y2H Array	25416956
Intra	ING5	Q8WYH8	ICA1	Homo sapiens	Q05084	Validated Y2H	25416956
Intra	ING5	Q8WYH8	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	CBY2	Homo sapiens	Q8NA61-2	Y2H Array	32296183
Intra	ING5	Q8WYH8	BRPF1	Homo sapiens	P55201-2	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	BRPF1	Homo sapiens	P55201-2	Y2H Array	32296183
Intra	ING5	Q8WYH8	JADE2	Homo sapiens	A0A0C4DFT8	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	JADE2	Homo sapiens	A0A0C4DFT8	Y2H Array	32296183
Intra	ING5	Q8WYH8	GGA1	Homo sapiens	Q9UJY5-4	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	GGA1	Homo sapiens	Q9UJY5-4	Validated Y2H	32296183
Intra	ING5	Q8WYH8	GGA1	Homo sapiens	Q9UJY5-4	Y2H Array	32296183
Intra	ING5	Q8WYH8	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	ING5	Q8WYH8	WASF1	Homo sapiens	Q92558	Validated Y2H	32296183
Intra	ING5	Q8WYH8	JADE2	Homo sapiens	Q9NQC1	Validated Y2H	25416956
Intra	ING5	Q8WYH8	JADE2	Homo sapiens	Q9NQC1	Anti Tag CoIP	33961781
Intra	ING5	Q8WYH8	JADE2	Homo sapiens	Q9NQC1	TAP	24981860
Intra	ING5	Q8WYH8	C3orf62	Homo sapiens	Q6ZUJ4	Y2H Array	25416956
Intra	ING5	Q8WYH8	C3orf62	Homo sapiens	Q6ZUJ4	Validated Y2H	25416956
Intra	ING5	Q8WYH8	THAP6	Homo sapiens	Q8TBB0	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	THAP6	Homo sapiens	Q8TBB0	Y2H Array	32296183
Intra	ING5	Q8WYH8	SMARCE1	Homo sapiens	Q969G3	Y2H Prey Pooling	25416956
Intra	ING5	Q8WYH8	SMARCE1	Homo sapiens	Q969G3	Y2H Array	25416956
Intra	ING5	Q8WYH8	CDCA7L	Homo sapiens	Q96GN5	Y2H Array	25416956
Intra	ING5	Q8WYH8	CDCA7L	Homo sapiens	Q96GN5	Y2H Prey Pooling	25416956
Intra	ING5	Q8WYH8	ARFIP2	Homo sapiens	P53365	Validated Y2H	25416956
Intra	ING5	Q8WYH8	ARFIP2	Homo sapiens	P53365	Y2H Prey Pooling	25416956
Intra	ING5	Q8WYH8	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183
Intra	ING5	Q8WYH8	KXD1	Homo sapiens	Q9BQD3	Validated Y2H	32296183
Intra	ING5	Q8WYH8	KXD1	Homo sapiens	Q9BQD3	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	KXD1	Homo sapiens	Q9BQD3	Y2H Array	32296183
Intra	ING5	Q8WYH8	HGS	Homo sapiens	O14964	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	HGS	Homo sapiens	O14964	Y2H Array	32296183
Intra	ING5	Q8WYH8	NAV2	Homo sapiens	Q8IVL1	Y2H Prey Pooling	25416956
Intra	ING5	Q8WYH8	NAV2	Homo sapiens	Q8IVL1	Y2H Array	25416956
Intra	ING5	Q8WYH8	NAV2	Homo sapiens	Q8IVL1	Y2H Pooling	16189514
Intra	ING5	Q8WYH8	NAV2	Homo sapiens	Q8IVL1	Anti Tag CoIP	33961781
Intra	ING5	Q8WYH8	BEX3	Homo sapiens	Q00994	Y2H Array	32296183
Intra	ING5	Q8WYH8	BEX3	Homo sapiens	Q00994	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	CEP44	Homo sapiens	Q9C0F1	Validated Y2H	25416956
Intra	ING5	Q8WYH8	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	25416956
Intra	ING5	Q8WYH8	DEUP1	Homo sapiens	Q05D60	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ING5 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75887	ING5 Protein, Human (His)	Q8WYH8-2 (E36-Q84)	≥95%

关联疾病

疾病名称

别名

Ohdo Syndrome, Sbbys Variant

Say-Barber-Biesecker-Young-Simpson Syndrome	SBBYSS
Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Sbbys Type
Yss	Sbbys Variant Of Ohdo Syndrome
Blepharophimosis - Intellectual Disability Syndrome, Sbbys Type	Young Simpson Syndrome
Sbbyss Syndrome	Ohdo Syndrome, Say-Barber-Biesecker-Young-Simpson Variant
Blepharophimosis And Mental Retardation Syndrome, Say-Barber/Biesecker/Young-Simpson Type	Blepharophimosis-Intellectual Deficit Syndrome, Say-Barber/Biesecker/Young-Simpson Type
Bmrs Sbbys	Ohdo Syndrome, Say-Barber-Biesecker Variant
Say-Barber-Biesecker-Young-Simpson Variant Of Ohdo Syndrome	Hypothyroidism-Dysmorphism-Postaxial Polydactyly-Intellectual Disability Syndrome
Say-Barber-Biesecker Variant Of Ohdo Syndrome

Ohdo Syndrome

Young Simpson Syndrome	Ohdo Blepharophimosis Syndrome
Blepharophimosis Syndrome Ohdo Type	Blepharophimosis Intellectual Disability Syndromes
Bmrs	Blepharophimosis-Intellectual Disability Syndrome
Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth	Sbbys Syndrome
Say Barber Biesecker Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type
Bmrs, Ohdo Type	Blepharophimosis Syndrome, Ohdo Type
Ohdo-Madokoro-Sonoda Syndrome	Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type
Blepharophimosis - Intellectual Disability Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06811	ING5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ING5	RGD	RGD:1307908
Canis familiaris	ING5	VGNC	VGNC:42019
Felis catus	ING5	VGNC	VGNC:107565
Bos taurus	ING5	VGNC	VGNC:30198
Macaca mulatta	ING5	VGNC	VGNC:73627
Mus musculus	ING5	MGD	MGI:1922816
Others	ING5	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4