2. Gene
  3. RBM15B - RNA binding motif protein 15B Gene

RBM15B - RNA binding motif protein 15B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RNA 结合基序蛋白 15B

种属: Homo sapiens

同用名: OTT3; HsOTT3; HUMAGCGB

基因 ID: 29890 | 基因类型: protein coding

关于 RBM15B

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,391,285-51,397,908 (from NCBI)

This gene has 1 transcript (splice variant), 225 orthologues and 7 paralogues.

功能概要

SPEN (Split-end) 蛋白质家族的成员，包括 RBM15B，在多个信号通路中具有抑制功能，并可能通过与剪接体成分的相互作用与 RNA 结合 (Hiriart 等人，2005 [PubMed 16129689]) 。[OMIM 提供, 2009 年 2 月]

Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

RBM15B 基因产物(1)

mRNA Protein Name
NM_013286.5 NP_037418.3 putative RNA-binding protein 15B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
27602518 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16129689 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RNA methylation IDA
IDA: 通过直接分析推断
27602518 GOA
involved in dosage compensation by inactivation of X chromosome IDA
IDA: 通过直接分析推断
27602518 GOA
NOT involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16129689 GOA
NOT involved in nucleocytoplasmic transport IDA
IDA: 通过直接分析推断
16129689 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
16129689 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA N6-methyladenosine methyltransferase complex IDA
IDA: 通过直接分析推断
27602518 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
19586903 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
19586903 GOA
NOT located in nucleolus IDA
IDA: 通过直接分析推断
16129689 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
16129689 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RBM15B 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (339 - 408)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (420 - 480)

SPOC

SPOC: SPOC domain (722 - 857)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 890 a.a.
蛋白主名 其他名称

putative RNA-binding protein 15B

chromosome 3p21.1 gene sequence

RBM15B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RBM15B Q8NDT2 NAV2 Homo sapiens Q8IVL1
Y2H Prey Pooling
25416956
种属内
RBM15B Q8NDT2 NAV2 Homo sapiens Q8IVL1
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11736 RBM15B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RBM15B VGNC VGNC:45410
Mus musculus RBM15B MGD MGI:1923598
Rattus norvegicus RBM15B RGD RGD:1305937
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