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  2. PIAS2 - protein inhibitor of activated STAT 2 Gene

PIAS2 - protein inhibitor of activated STAT 2 Gene

中文名称:激活的 STAT 2 蛋白抑制因子

种属: Homo sapiens

同用名: DIP; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4

基因 ID: 9063 | 基因类型: protein coding

关于 PIAS2

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:46,803,218-46,920,145 (from NCBI)

This gene has 16 transcripts (splice variants), 219 orthologues and 5 paralogues. Broad expression in testis (RPKM 8.9), thyroid (RPKM 2.1) and 23 other tissues.

功能概要

该基因编码激活的 STAT 家族蛋白抑制剂的成员,其作为 SUMO E3 连接酶发挥作用,并通过介导靶蛋白的 sumoylation 在许多细胞过程中发挥重要作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。所编码蛋白质的异构体增强特定靶蛋白的苏木化,包括 p53 肿瘤抑制蛋白、c-Jun 和雄激素受体。该基因的假基因位于 4 号染色体的短臂上。符号 MIZ1 也与 ZBTB17 相关联,ZBTB17 是位于 1 号染色体上的不同基因。[RefSeq 提供,2017 年 8 月]

This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 Ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the Androgen Receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]

PIAS2 基因产物(22)

mRNA Protein Name
NM_001324046.2 NP_001310975.1 E3 SUMO-protein ligase PIAS2 isoform 4
NM_001324047.2 NP_001310976.1 E3 SUMO-protein ligase PIAS2 isoform 5
NM_001324048.2 NP_001310977.1 E3 SUMO-protein ligase PIAS2 isoform 6
NM_001324049.2 NP_001310978.1 E3 SUMO-protein ligase PIAS2 isoform 6
NM_001324051.2 NP_001310980.1 E3 SUMO-protein ligase PIAS2 isoform 7
NM_001324052.2 NP_001310981.1 E3 SUMO-protein ligase PIAS2 isoform 7
NM_001324053.2 NP_001310982.1 E3 SUMO-protein ligase PIAS2 isoform 7
NM_001324054.2 NP_001310983.1 E3 SUMO-protein ligase PIAS2 isoform 7
NM_001324055.2 NP_001310984.1 E3 SUMO-protein ligase PIAS2 isoform 8
NM_001324057.2 NP_001310986.1 E3 SUMO-protein ligase PIAS2 isoform 8
NM_001324058.2 NP_001310987.1 E3 SUMO-protein ligase PIAS2 isoform 9
NM_001324059.2 NP_001310988.1 E3 SUMO-protein ligase PIAS2 isoform 8
NM_001324060.2 NP_001310989.1 E3 SUMO-protein ligase PIAS2 isoform NY
NM_001354033.2 NP_001340962.1 E3 SUMO-protein ligase PIAS2 isoform 7
NM_001354034.2 NP_001340963.1 E3 SUMO-protein ligase PIAS2 isoform 10
NM_001354035.2 NP_001340964.1 E3 SUMO-protein ligase PIAS2 isoform 6
NM_001354036.2 NP_001340965.1 E3 SUMO-protein ligase PIAS2 isoform 6
NM_001354037.2 NP_001340966.1 E3 SUMO-protein ligase PIAS2 isoform 8
NM_001354038.2 NP_001340967.1 E3 SUMO-protein ligase PIAS2 isoform 5
NM_001354039.2 NP_001340968.1 E3 SUMO-protein ligase PIAS2 isoform 5
NM_004671.5 NP_004662.2 E3 SUMO-protein ligase PIAS2 isoform beta
NM_173206.4 NP_775298.1 E3 SUMO-protein ligase PIAS2 isoform alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
20408817 GOA
enables SUMO ligase activity IDA
IDA: 通过直接分析推断
18579533 GOA
enables SUMO transferase activity EXP
EXP: 通过实验结果推断
12393906 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11477070 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in SMAD protein signal transduction IDA
IDA: 通过直接分析推断
16777850 GOA
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
20408817 GOA
involved in negative regulation of androgen receptor signaling pathway IDA
IDA: 通过直接分析推断
11477070 GOA
involved in protein sumoylation IDA
IDA: 通过直接分析推断
20408817 GOA
NOT involved in transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
16777850 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with PML body IDA
IDA: 通过直接分析推断
22406621 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11477070 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PIAS2 蛋白结构

PINIT

PINIT: PINIT domain (141 - 297)

zf-MIZ

zf-MIZ: MIZ/SP-RING zinc finger (342 - 390)

  • 0
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  • 500
  • 621 a.a.
蛋白主名 其他名称

E3 SUMO-protein ligase PIAS2

DAB2-interacting protein

PIAS2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PIAS2 O75928 CCHCR1 Homo sapiens Q8TD31-3 25416956
种属内
PIAS2 O75928 CCHCR1 Homo sapiens Q8TD31-3 25416956
种属内
PIAS2 O75928 CCHCR1 Homo sapiens Q8TD31-3 25416956
种属内
PIAS2 O75928 UBE2I Homo sapiens Q7KZS0 25416956
种属内
PIAS2 O75928 UBE2I Homo sapiens Q7KZS0 25416956
种属内
PIAS2 O75928 UBE2I Homo sapiens Q7KZS0 25416956
种属内
PIAS2 O75928 MX2 Homo sapiens P20592 25416956
种属内
PIAS2 O75928 q59gp6_human Homo sapiens Q59GP6 25416956
种属内
PIAS2 O75928 PRKAB2 Homo sapiens O43741 25416956
种属内
PIAS2 O75928 PRKAB2 Homo sapiens O43741 25416956
种属内
PIAS2 O75928 RACK1 Homo sapiens P63244 22210188
种属内
PIAS2 O75928 ACY3 Homo sapiens Q96HD9 25416956
种属内
PIAS2 O75928 RUFY1 Homo sapiens Q96T51 21988832
种属内
PIAS2 O75928 RUFY1 Homo sapiens Q96T51
Y2H
21988832
种属内
PIAS2 O75928 MYC Homo sapiens P01106 17418410
种属内
PIAS2 O75928 GOLGA2 Homo sapiens Q08379 25416956
种属内
PIAS2 O75928 GOLGA2 Homo sapiens Q08379 25416956
种属内
PIAS2 O75928 TRIM23 Homo sapiens P36406 25416956
种属内
PIAS2 O75928 TRIM23 Homo sapiens P36406 25416956
种属内
PIAS2 O75928 NAV2 Homo sapiens Q8IVL1 16189514
种属内
PIAS2 O75928 NAV2 Homo sapiens Q8IVL1 25416956
种属内
PIAS2 O75928 NAV2 Homo sapiens Q8IVL1 25416956
种属内
PIAS2 O75928 ZBTB8A Homo sapiens Q96BR9 25416956
种属内
PIAS2 O75928 ZBTB8A Homo sapiens Q96BR9 25416956
种属内
PIAS2 O75928 TSR2 Homo sapiens Q969E8 25416956
种属内
PIAS2 O75928 TSR2 Homo sapiens Q969E8 25416956
种属内
PIAS2 O75928 CCNDBP1 Homo sapiens O95273 25416956
种属内
PIAS2 O75928 CCNDBP1 Homo sapiens O95273 25416956
种属内
PIAS2 O75928 SUMO1 Homo sapiens P63165 25416956
种属内
PIAS2 O75928 SUMO1 Homo sapiens P63165 25416956
种属内
PIAS2 O75928 SUMO1 Homo sapiens P63165
ITC
16204249
种属内
PIAS2 O75928 UBE2I Homo sapiens P63279
Y2H
19549727
种属内
PIAS2 O75928 UBE2I Homo sapiens P63279 20936779
种属内
PIAS2 O75928 UBE2I Homo sapiens P63279 21988832
种属内
PIAS2 O75928 UBE2I Homo sapiens P63279
Y2H
21988832
种属内
PIAS2 O75928 UBE2I Homo sapiens P63279 25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

PIAS2 抗体

目录号 产品名 应用 反应物种
HY-P82730 PIAS1/2 Antibody (YA2475) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P82985 PIAS2 Antibody (YA2730) WB, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PIAS2 VGNC VGNC:75815
Bos taurus PIAS2 VGNC VGNC:97299
Canis familiaris PIAS2 VGNC VGNC:44520
Felis catus PIAS2 VGNC VGNC:82550
Rattus norvegicus PIAS2 RGD RGD:71056
Mus musculus PIAS2 MGD MGI:1096566