2. Gene
  3. MX2 - MX dynamin like GTPase 2 Gene

MX2 - MX dynamin like GTPase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MX 动力蛋白样 GTPase 2

种属: Homo sapiens

同用名: MXB

基因 ID: 4600 | 基因类型: protein coding

关于 MX2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:41,362,027-41,409,393 (from NCBI)

This gene has 18 transcripts (splice variants), 102 orthologues and 6 paralogues. Broad expression in spleen (RPKM 16.5), appendix (RPKM 13.6) and 23 other tissues.

功能概要

由该基因编码的蛋白质具有细胞核和细胞质形式，是动力蛋白家族和大 GTP 酶家族的成员。核形式位于核膜下方异染色质区域的颗粒状结构中。核定位信号 (NLS) 存在于核形式的氨基末端，但由于使用了替代翻译起始密码子，因此在细胞质形式中缺失。该蛋白被干扰素-α 上调，但不包含类似粘液病毒抗性蛋白 1 的抗病毒活性。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the Dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the Antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]

MX2 基因产物(1)

mRNA Protein Name
NM_002463.2 NP_002454.1 interferon-induced GTP-binding protein Mx2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTP binding IMP
IMP: 通过突变表型推断
15184662 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in defense response to virus IMP
IMP: 通过突变表型推断
24121441 GOA
involved in regulation of cell cycle IMP
IMP: 通过突变表型推断
15184662 GOA
involved in regulation of nucleocytoplasmic transport IMP
IMP: 通过突变表型推断
15184662 GOA
involved in response to interferon-alpha IDA
IDA: 通过直接分析推断
24121441 GOA
involved in response to virus IDA
IDA: 通过直接分析推断
24048477 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of nuclear pore IDA
IDA: 通过直接分析推断
15184662 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MX2 蛋白结构

Dynamin_N

Dynamin_N: Dynamin family (121 - 295)

Dynamin_M

Dynamin_M: Dynamin central region (307 - 594)

GED

GED: Dynamin GTPase effector domain (622 - 709)

  • 0
  • 200
  • 400
  • 600
  • 715 a.a.
蛋白主名 其他名称

interferon-induced GTP-binding protein Mx2

interferon-regulated resistance GTP-binding protein MXB

MX2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MX2 P20592 EHMT2 Homo sapiens A2ABF9
Validated Y2H
25416956
种属内
MX2 P20592 EHMT2 Homo sapiens A2ABF9
Y2H Prey Pooling
25416956
种属内
MX2 P20592 PIAS2 Homo sapiens O75928
Validated Y2H
25416956
种属内
MX2 P20592 PIAS2 Homo sapiens O75928
Y2H Prey Pooling
25416956
种属内
MX2 P20592 EHMT2 Homo sapiens Q96KQ7
Y2H Prey Pooling
32296183
种属内
MX2 P20592 EHMT2 Homo sapiens Q96KQ7
Validated Y2H
32296183
种属内
MX2 P20592 EHMT2 Homo sapiens Q96KQ7
Y2H Array
32296183
种属内
MX2 P20592 ATRIP Homo sapiens Q8WXE1
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Pediculus Humanus Corporis Infestation

Body Louse Infestation

Pediculus Corporis

Pediculus Humanus Infestation
Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome

Ophthalmoacromelic Syndrome

OAS

MLA

Anophthalmia-Syndactyly

Anophthalmia-Syndactyly Syndrome

Anophthalmos With Limb Anomalies

Anophthalmia Waardenburg Syndrome

Anophthalmos-Syndactyly

Ophthalmo-Acromelic Syndrome

Anophthalmia-Waardenburg Syndrome

Anophthalmos-Limb Anomalies Syndrome

Syndactyly-Anophthalmos Syndrome

Microphthalmia, With Limb Anomalies
Narcolepsy

Paroxysmal Sleep

Gelineau Syndrome

Narcoleptic Syndrome

Narcolepsy-Cataplexy Syndrome

Cataplexy And Narcolepsy

Narcolepsy, Without Cataplexy

Gelineau'S Syndrome

Narcolepsy With Or Without Cataplexy

Narcolepsy Nos
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08860 MX2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MX2 VGNC VGNC:43512
Macaca mulatta MX2 VGNC VGNC:81723
Bos taurus MX2 VGNC VGNC:50221
Others MX2 NCBI
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