CCNDBP1 - cyclin D1 binding protein 1 Gene

中文名称：细胞周期蛋白 D1 结合蛋白 1

种属: Homo sapiens

同用名: HHM; DIP1; GCIP

关于 CCNDBP1

功能概要

该基因是通过其基因产物与 Grap2 的相互作用而鉴定的，Grap2 是一种对免疫细胞信号传导很重要的白细胞特异性衔接蛋白。该基因编码的蛋白质显示与细胞周期蛋白 D 相互作用。据报道，在细胞中转染该基因可降低细胞周期蛋白 D 依赖性蛋白激酶对 Rb 基因产物的磷酸化，并抑制 E2F1 介导的转录活性。还发现该蛋白与螺旋-环-螺旋蛋白 E12 相互作用，被认为是肝脏特异性基因表达的负调节因子。已发现该基因的几种可变剪接变体。[RefSeq 提供，2009 年 4 月]

This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]