RPS28 - ribosomal protein S28 Gene

中文名称：核糖体蛋白 S28

种属: Homo sapiens

同用名: S28; eS28; DBA15

基因 ID: 6234 | 基因类型: protein coding

关于 RPS28

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,321,496-8,323,340 (from NCBI)

This gene has 4 transcripts (splice variants), 189 orthologues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 563.4), spleen (RPKM 434.5) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 40S 亚基的一个组成部分。该蛋白属于核糖体蛋白 S28E 家族。它位于细胞质中。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。[RefSeq 提供，2008 年 7 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS28 基因产物(1)

mRNA	Protein	Name
NM_001031.5	NP_001022.1	40S ribosomal protein S28

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables structural constituent of ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
enables structural constituent of ribosome	IMP IMP: 通过突变表型推断	18697920	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cytoplasmic translation	IDA IDA: 通过直接分析推断	25957688	GOA
involved in rRNA processing	IMP IMP: 通过突变表型推断	18697920	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: 通过直接分析推断	34516797	GOA
involved in ribosomal small subunit biogenesis	IMP IMP: 通过突变表型推断	18697920	GOA
involved in ribosome biogenesis	IMP IMP: 通过突变表型推断	24942156	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of cytosolic small ribosomal subunit	IDA IDA: 通过直接分析推断	8706699	GOA
located in ribosome	IDA IDA: 通过直接分析推断	25957688	GOA
part of small-subunit processome	IDA IDA: 通过直接分析推断	34516797	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPS28 蛋白结构

Ribosomal_S28e

0
69 a.a.

蛋白主名

其他名称

40S ribosomal protein S28

small ribosomal subunit protein eS28

RPS28 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RPS28	P62857	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	RPS28	P62857	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	RPS28	P62857	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	RPS28	P62857	KRTAP2-3	Homo sapiens	P0C7H8	Y2H Array	25416956
Intra	RPS28	P62857	KRTAP2-3	Homo sapiens	P0C7H8	Y2H Prey Pooling	25416956
Intra	RPS28	P62857	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	RPS28	P62857	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	RPS28	P62857	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	RPS28	P62857	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	RPS28	P62857	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	RPS28	P62857	CCNDBP1	Homo sapiens	O95273	Y2H Array	25416956
Intra	RPS28	P62857	CCNDBP1	Homo sapiens	O95273	Validated Y2H	25416956
Intra	RPS28	P62857	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	RPS28	P62857	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Diamond-Blackfan Anemia 15 With Mandibulofacial Dysostosis

DBA15	Diamond Blackfan Anemia 15 With Mandibulofacial Dysostosis
Diamond-Blackfan Anemia 15, With Mandibulofacial Dysostosis	Diamond-Blackfan Anemia With Microtia And Cleft Palate
Anemia, Diamond Blackfan, Type 15 With Mandibulofacial Dysostosis

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Macrocytic Anemia

Anemia Macrocytic	Anemia, Macrocytic
Macrocytic Anaemia

Diamond-Blackfan Anemia 10

DBA10	Rps26-Related Diamond-Blackfan Anemia
Anemia, Diamond-Blackfan, Type 10

Chromosome 5q Deletion Syndrome

5q- Syndrome	Mar
Myelodysplastic Syndrome Associated With Isolated Del Chromosome Abnormality	Macrocytic Anemia, Refractory, Due To 5q Deletion, Somatic
5q Deletion Syndrome	5q Minus Syndrome
Refractory Macrocytic Anemia Due To 5q Deletion	Myelodysplastic Syndrome With Isolated Del
Macrocytic Anemia, Refractory, Due To 5q Deletion	5q- Syndrome, Refractory Macrocytic Anemia Due To 5q Deletion
5q Syndrome	Chromosome 5q Deletion
Myelodysplastic Syndrome With 5q Deletion	Myelodysplastic Syndrome With 5q Deletion Syndrome
Anemia, Macrocytic, Refractory, Due To 5q Deletion, Somatic	5q-Syndrome
Chromosome 5, Trisomy 5q	Loss Of Chromosome 5q
5 Q- Syndrome

Erythrasma

Infection Due To Corynebacterium Minutissimum

Dysostosis

Dysostoses

Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome	Shwachman Syndrome
Shwachman-Bodian-Diamond Syndrome	Sds
Pancreatic Insufficiency And Bone Marrow Dysfunction	Shwachman-Bodian Syndrome
SDS1	Lipomatosis Of Pancreas, Congenital
Congenital Lipomatosis Of Pancreas	Shwachman-Diamond Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia, Shwachman Type	Shwachman-Diamond-Oski Syndrome

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12240	RPS28 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	RPS28	VGNC	VGNC:80709
Mus musculus	RPS28	MGD	MGI:1859516
Rattus norvegicus	RPS28	RGD	RGD:621046
Bos taurus	RPS28	VGNC	VGNC:34136
Canis familiaris	RPS28	VGNC	VGNC:108256

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