PSMB10 - proteasome 20S subunit beta 10 Gene

中文名称：蛋白酶体 20S 亚基 beta 10

种属: Homo sapiens

同用名: LMP10; MECL1; PRAAS5; beta2i

关于 PSMB10

功能概要

蛋白酶体是一种多催化蛋白酶复合物，具有高度有序的环状 20S 核心结构。核心结构由 28 个不同亚基的 4 个环组成； 2 个环由 7 个α亚基组成，2 个环由 7 个β亚基组成。蛋白酶体以高浓度分布在整个真核细胞中，并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。修饰的蛋白酶体 (免疫蛋白酶体) 的基本功能是加工 I 类 MHC 肽。该基因编码蛋白酶体 B 型家族的成员，也称为 T1B 家族，是一个 20S 核心 β 亚基。需要蛋白水解加工来产生成熟的亚基。该基因的表达由γ干扰素诱导，该基因产物取代了免疫蛋白酶体中的催化亚基 2 (蛋白酶体β7 亚基) 。[RefSeq 提供，2008 年 7 月]

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the Proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (Proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]