COPS5 - COP9 signalosome subunit 5 Gene

中文名称：COP9 信号体亚基 5

种属: Homo sapiens

同用名: CSN5; JAB1; SGN5; MOV-34

基因 ID: 10987 | 基因类型: protein coding

关于 COPS5

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:67,043,079-67,062,133 (from NCBI)

This gene has 13 transcripts (splice variants), 224 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 37.3), heart (RPKM 32.6) and 25 other tissues.

功能概要

该基因编码的蛋白质是 COP9 信号体的八个亚基之一，COP9 信号体是一种高度保守的蛋白质复合物，在多个信号通路中起重要调节作用。 COP9 信号体的结构和功能类似于 26S 蛋白酶体的 19S 调节颗粒。 COP9 信号体已被证明与 SCF 型 E3 泛素连接酶相互作用，并作为 E3 泛素连接酶的正调节剂。据报道，该蛋白参与细胞周期蛋白依赖性激酶抑制剂 CDKN1B/p27Kip1 的降解。还已知它是一种共激活剂，可增加 JUN/AP1 转录因子的特异性。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S Proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

COPS5 基因产物(1)

mRNA	Protein	Name
NM_006837.3	NP_006828.2	COP9 signalosome complex subunit 5

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables metal-dependent deubiquitinase activity	IDA IDA: 通过直接分析推断	19246649	GOA
enables metallopeptidase activity	IMP IMP: 通过突变表型推断	19214193	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12082530	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in exosomal secretion	IDA IDA: 通过直接分析推断	19246649	GOA
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	20978819	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	20978819	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16410250	GOA
involved in protein deneddylation	IDA IDA: 通过直接分析推断	19141280	GOA
involved in protein deneddylation	IMP IMP: 通过突变表型推断	19214193	GOA
involved in regulation of IRE1-mediated unfolded protein response	IMP IMP: 通过突变表型推断	15234121	GOA
involved in regulation of JNK cascade	IDA IDA: 通过直接分析推断	16410250	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of COP9 signalosome	IDA IDA: 通过直接分析推断	18850735	GOA
part of COP9 signalosome	IPI IPI: 通过物理相互作用推断	25043011	GOA
located in chromatin	IDA IDA: 通过直接分析推断	20978819	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	16300740	GOA
located in cytosol	IDA IDA: 通过直接分析推断	20978819	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16300740	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	16300740	GOA
located in synaptic vesicle	IDA IDA: 通过直接分析推断	21102408	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

COPS5 蛋白结构

JAB

0
100
200
300
334 a.a.

蛋白主名

其他名称

COP9 signalosome complex subunit 5

38 kDa Mov34 homolog

COPS5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	COPS5	Q92905	RNF20	Homo sapiens	Q5VTR2	Anti Tag CoIP	19214193
种属内	COPS5	Q92905	OPRM1	Homo sapiens	P35372	Y2H	23840749
种属内	COPS5	Q92905	OPRM1	Homo sapiens	P35372	Anti Tag CoIP	23840749
种属内	COPS5	Q92905	OPRM1	Homo sapiens	P35372	Pull Down	23840749
种属内	COPS5	Q92905	BRSK2	Homo sapiens	Q8IWQ3	Pull Down	22609399
种属内	COPS5	Q92905	BRSK2	Homo sapiens	Q8IWQ3	Confocal	22609399
种属内	COPS5	Q92905	BRSK2	Homo sapiens	Q8IWQ3	Anti Bait CoIP	22609399
种属内	COPS5	Q92905	BRSK2	Homo sapiens	Q8IWQ3	Y2H	22609399
种属内	COPS5	Q92905	BRSK2	Homo sapiens	Q8IWQ3	Anti Tag CoIP	22609399
种属内	COPS5	Q92905	COPS3	Homo sapiens	Q9UNS2	TAP	18850735
种属内	COPS5	Q92905	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	19615732
种属内	COPS5	Q92905	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	20399188
种属内	COPS5	Q92905	COPS3	Homo sapiens	Q9UNS2	TAP	21145461
种属内	COPS5	Q92905	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	33961781
种属内	COPS5	Q92905	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	28514442
种属内	COPS5	Q92905	SMAD7	Homo sapiens	O15105	Confocal	14993265
种属内	COPS5	Q92905	SMAD7	Homo sapiens	O15105	Pull Down	14993265
种属内	COPS5	Q92905	SMAD7	Homo sapiens	O15105	Anti Tag CoIP	14993265
种属内	COPS5	Q92905	SMAD7	Homo sapiens	O15105	Y2H	14993265
种属内	COPS5	Q92905	F2RL1	Homo sapiens	P55085	Y2H	16410250
种属内	COPS5	Q92905	F2RL1	Homo sapiens	P55085	Anti Bait CoIP	16410250
种属内	COPS5	Q92905	F2RL1	Homo sapiens	P55085	Confocal	16410250
种属内	COPS5	Q92905	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	33961781
种属内	COPS5	Q92905	CUL3	Homo sapiens	Q13618	TAP	21145461
种属内	COPS5	Q92905	CUL3	Homo sapiens	Q13618	TAP	18850735
种属内	COPS5	Q92905	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	19615732
种属内	COPS5	Q92905	COPS6	Homo sapiens	Q7L5N1	Anti Tag CoIP	20399188
种属内	COPS5	Q92905	COPS6	Homo sapiens	Q7L5N1	Pull Down	25043011
种属内	COPS5	Q92905	COPS6	Homo sapiens	Q7L5N1	TAP	18850735
种属内	COPS5	Q92905	COPS6	Homo sapiens	Q7L5N1	Anti Tag CoIP	19615732
种属内	COPS5	Q92905	COPS6	Homo sapiens	Q7L5N1	TAP	21145461
种属内	COPS5	Q92905	CDKN1B	Homo sapiens	P46527	Pull Down	15480426
种属内	COPS5	Q92905	TXN	Homo sapiens	P10599	Pull Down	15480426
种属内	COPS5	Q92905	TXN	Homo sapiens	P10599	TAP	21145461
种属内	COPS5	Q92905	TXN	Homo sapiens	P10599	Anti Bait CoIP	15480426
种属内	COPS5	Q92905	TXN	Homo sapiens	P10599	FRET	15480426
种属内	COPS5	Q92905	UCHL1	Homo sapiens	P09936	Y2H	12082530
种属内	COPS5	Q92905	UCHL1	Homo sapiens	P09936	IF	12082530
种属内	COPS5	Q92905	UCHL1	Homo sapiens	P09936	Anti Bait CoIP	12082530
种属内	COPS5	Q92905	MINDY3	Homo sapiens	Q9H8M7	Anti Tag CoIP	21499297
种属内	COPS5	Q92905	MINDY3	Homo sapiens	Q9H8M7	Y2H	21499297
种属内	COPS5	Q92905	GPS1	Homo sapiens	Q13098	Anti Tag CoIP	19615732
种属内	COPS5	Q92905	GPS1	Homo sapiens	Q13098	Anti Tag CoIP	20399188
种属内	COPS5	Q92905	GPS1	Homo sapiens	Q13098	TAP	21145461
种属内	COPS5	Q92905	GPS1	Homo sapiens	Q13098	TAP	18850735
种属内	COPS5	Q92905	GPS1	Homo sapiens	Q13098	Anti Tag CoIP	33961781
种属内	COPS5	Q92905	GTPBP3	Homo sapiens	Q969Y2	Validated Y2H	32296183
种属内	COPS5	Q92905	CCNDBP1	Homo sapiens	O95273	Confocal	15887118

种属间: 跨种属相互作用 种属内: 同种属相互作用

COPS5 抗体

目录号	产品名	应用	反应物种
HY-P83414	JAB1 Antibody (YA3159)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Maxillary Sinus Adenocarcinoma

Adenocarcinoma Of Maxillary Sinus

Adenocarcinoma Of The Maxillary Sinus

Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V	Xp5
Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype	Xpe
Xp, Group E	Xeroderma Pigmentosum, Type 5
Xeroderma Pigmentosum Complementation Group E	XP-E
Xp Group E

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Hereditary Ataxia

Sca	Spinocerebellar Ataxia
Ataxias Hereditary	Ataxias, Hereditary

Cerebellar Disease

Cerebellar Diseases	Cerebellar Dysfunction
Cerebellar Abnormality	Cerebellar Disorders

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03030	COPS5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	COPS5	VGNC	VGNC:61090
Mus musculus	COPS5	MGD	MGI:1349415
Macaca mulatta	COPS5	VGNC	VGNC:71317
Bos taurus	COPS5	VGNC	VGNC:27602
Rattus norvegicus	COPS5	RGD	RGD:1310301
Canis familiaris	COPS5	VGNC	VGNC:54110
Others	COPS5	NCBI

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站点地图隐私声明

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

COPS5 - COP9 signalosome subunit 5 Gene

关于 COPS5

功能概要

COPS5 基因产物(1)

COPS5 蛋白结构

COPS5 蛋白互作信息

COPS5 抗体

关联疾病

直系同源

热门区域

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COPS5 - COP9 signalosome subunit 5 Gene

关于 COPS5

功能概要

COPS5 基因产物(1)

COPS5 蛋白结构

COPS5 蛋白互作信息

COPS5 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

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