2. Gene
  3. BRSK2 - BR serine/threonine kinase 2 Gene

BRSK2 - BR serine/threonine kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：BR 丝氨酸/苏氨酸激酶 2

种属: Homo sapiens

同用名: SAD1; SADA; SAD-A; STK29; PEN11B; C11orf7

基因 ID: 9024 | 基因类型: protein coding

关于 BRSK2

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,389,934-1,462,689 (from NCBI)

This gene has 15 transcripts (splice variants), 308 orthologues, 17 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 8.8), pancreas (RPKM 3.6) and 2 other tissues.

功能概要

启用多项功能，包括 ATP 绑定活动； ATP 酶结合活性；和蛋白激酶活性。参与多个过程，包括细胞蛋白质代谢过程；响应内质网应激的内在凋亡信号通路；调节参与细胞对葡萄糖刺激的反应的胰岛素分泌。位于中心体和内质网。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; ATPase binding activity; and protein kinase activity. Involved in several processes, including cellular protein metabolic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of Insulin secretion involved in cellular response to glucose stimulus. Located in centrosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

BRSK2 基因产物(5)

mRNA Protein Name
NM_001256627.2 NP_001243556.1 serine/threonine-protein kinase BRSK2 isoform 1
NM_001256629.2 NP_001243558.1 serine/threonine-protein kinase BRSK2 isoform 3
NM_001256630.1 NP_001243559.1 serine/threonine-protein kinase BRSK2 isoform 4
NM_001282218.2 NP_001269147.1 serine/threonine-protein kinase BRSK2 isoform 5
NM_003957.4 NP_003948.2 serine/threonine-protein kinase BRSK2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
14976552 GOA
enables ATPase binding IDA
IDA: 通过直接分析推断
23907667 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
14976552 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22609399 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
14976552 GOA
enables tau-protein kinase activity IDA
IDA: 通过直接分析推断
21985311 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERAD pathway IMP
IMP: 通过突变表型推断
23907667 GOA
involved in G2/M transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
23029325 GOA
involved in actin cytoskeleton organization IMP
IMP: 通过突变表型推断
22669945 GOA
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
22713462 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
14976552 GOA
involved in regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
22669945 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
23029325 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
22713462 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
23907667 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BRSK2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (19 - 269)

  • 0
  • 200
  • 400
  • 600
  • 736 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase BRSK2

BR serine/threonine-protein kinase 2

BRSK2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BRSK2 Q8IWQ3 YWHAE Homo sapiens P62258
Crosslink
36931259
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Autosomal Dominant Non-Syndromic Intellectual Disability
Carrion'S Disease

Oroya Fever

Carrion Disease

Bartonellosis Due To Bartonella Bacilliformis Infection

Bartonella Infections

Systemic Bartonellosis Due To Bartonella Bacilliformis

Systemic Carrión Disease

Systemic Bartonellosis

Bartonella Fever
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-18174 Prexasertib 98.74% Phase 2
HY-18174A Prexasertib dihydrochloride 99.41% Phase 2
HY-18174E Prexasertib dimesylate 99.04% Phase 2
HY-18174B Prexasertib Mesylate Hydrate / Phase 2
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18174C Prexasertib mesylate / 否
HY-RS01638 BRSK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-18174H Prexasertib lactate / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta BRSK2 VGNC VGNC:70291
Felis catus BRSK2 VGNC VGNC:60185
Bos taurus BRSK2 VGNC VGNC:56257
Rattus norvegicus BRSK2 RGD RGD:1566256
Mus musculus BRSK2 MGD MGI:1923020
Canis familiaris BRSK2 VGNC VGNC:51843
Others BRSK2 NCBI
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