F2RL1 - F2R like trypsin receptor 1 Gene

中文名称：F2R 样胰蛋白酶受体 1

种属: Homo sapiens

同用名: PAR2; GPR11

基因 ID: 2150 | 基因类型: protein coding

关于 F2RL1

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:76,819,030-76,835,315 (from NCBI)

This gene has 2 transcripts (splice variants), 307 orthologues and 16 paralogues. Broad expression in colon (RPKM 30.3), duodenum (RPKM 21.7) and 16 other tissues.

功能概要

该基因编码 G 蛋白偶联受体 1 蛋白家族的成员。编码的细胞表面受体通过其细胞外氨基末端的蛋白水解切割而被激活，从而产生一个新的氨基末端，该氨基末端充当与细胞外环结构域结合的束缚配体。受体的激活已被证明可以刺激血管平滑肌松弛、扩张血管、增加血流量和降低血压。这种蛋白质在炎症反应以及先天免疫和适应性免疫中也很重要。[RefSeq 提供，2016 年 6 月]

This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]

F2RL1 基因产物(1)

mRNA	Protein	Name
NM_005242.6	NP_005233.4	proteinase-activated receptor 2 preproprotein

F2RL1 蛋白结构

7tm_1

0
100
200
300
397 a.a.

蛋白主名

其他名称

proteinase-activated receptor 2

G-protein coupled receptor 11	coagulation factor II (thrombin) receptor-like 1
protease-activated receptor 2	thrombin receptor-like 1

关联疾病

疾病名称

别名

Pancreatitis

Mumps Pancreatitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Alzheimer Disease 12

Ad12	Alzheimer'S Disease 12
Alzheimer Disease, Familial, 12	Alzheimer Disease Familial 12

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Gastroesophageal Reflux

Gastroesophageal Reflux Disease	Gerd
GER	Gastroesophageal Reflux, Pediatric
Acid Reflux	Gastresophageal Reflux
Gastro-Esophageal Reflux	Gerd - Gastro-Esophageal Reflux Disease

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Granulomatous Orchitis

Non-Specific Granulomatous Orchitis

Vernal Keratoconjunctivitis

Vkc	Spring Catarrh
Keratoconjunctivitis Vernal	Keratoconjunctivitis, Vernal

Neuroleptic Malignant Syndrome

Rhinitis

Runny Nose

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04634	F2RL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04635	F2rl1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04636	F2rl1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	F2RL1	VGNC	VGNC:28684
Canis familiaris	F2RL1	VGNC	VGNC:40549
Mus musculus	F2RL1	MGD	MGI:101910
Macaca mulatta	F2RL1	VGNC	VGNC:110468
Rattus norvegicus	F2RL1	RGD	RGD:620866

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

F2RL1 - F2R like trypsin receptor 1 Gene

关于 F2RL1

功能概要

F2RL1 基因产物(1)

F2RL1 蛋白结构

关联疾病

直系同源

热门区域

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F2RL1 - F2R like trypsin receptor 1 Gene

关于 F2RL1

功能概要

F2RL1 基因产物(1)

F2RL1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z