2. Gene
  3. F2RL1 - F2R like trypsin receptor 1 Gene

F2RL1 - F2R like trypsin receptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：F2R 样胰蛋白酶受体 1

种属: Homo sapiens

同用名: PAR2; GPR11

基因 ID: 2150 | 基因类型: protein coding

关于 F2RL1

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:76,819,030-76,835,315 (from NCBI)

This gene has 2 transcripts (splice variants), 307 orthologues and 16 paralogues. Broad expression in colon (RPKM 30.3), duodenum (RPKM 21.7) and 16 other tissues.

功能概要

该基因编码 G 蛋白偶联受体 1 蛋白家族的成员。编码的细胞表面受体通过其细胞外氨基末端的蛋白水解切割而被激活，从而产生一个新的氨基末端，该氨基末端充当与细胞外环结构域结合的束缚配体。受体的激活已被证明可以刺激血管平滑肌松弛、扩张血管、增加血流量和降低血压。这种蛋白质在炎症反应以及先天免疫和适应性免疫中也很重要。[RefSeq 提供，2016 年 6 月]

This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]

F2RL1 基因产物(1)

mRNA Protein Name
NM_005242.6 NP_005233.4 proteinase-activated receptor 2 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IMP
IMP: 通过突变表型推断
18622013 GOA
enables protease binding IPI
IPI: 通过物理相互作用推断
18434511 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10725339 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
28445455 GOA
involved in cell-cell junction maintenance IMP
IMP: 通过突变表型推断
23202369 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
18453611 GOA
involved in establishment of endothelial barrier IDA
IDA: 通过直接分析推断
20826780 GOA
involved in leukocyte migration IDA
IDA: 通过直接分析推断
15155775 GOA
involved in mature conventional dendritic cell differentiation IDA
IDA: 通过直接分析推断
16478888 GOA
involved in negative regulation of JNK cascade IDA
IDA: 通过直接分析推断
19781631 GOA
involved in negative regulation of chemokine production IDA
IDA: 通过直接分析推断
19865078 GOA
involved in negative regulation of toll-like receptor 3 signaling pathway IMP
IMP: 通过突变表型推断
19865078 GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: 通过直接分析推断
19781631 GOA
involved in neutrophil activation IDA
IDA: 通过直接分析推断
15155775 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
10725339 GOA
involved in positive regulation of GTPase activity IMP
IMP: 通过突变表型推断
23202369 GOA
involved in positive regulation of JNK cascade IDA
IDA: 通过直接分析推断
11413129 GOA
involved in positive regulation of Rho protein signal transduction IMP
IMP: 通过突变表型推断
20826780 GOA
involved in positive regulation of actin filament depolymerization IDA
IDA: 通过直接分析推断
17500066 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
11413129 GOA
involved in positive regulation of chemokine production IDA
IDA: 通过直接分析推断
19494303 GOA
involved in positive regulation of cytokine production involved in immune response IDA
IDA: 通过直接分析推断
11441110 GOA
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
10725339 GOA
involved in positive regulation of eosinophil degranulation IDA
IDA: 通过直接分析推断
11714832 GOA
involved in positive regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
15155775 GOA
involved in positive regulation of interleukin-10 production IDA
IDA: 通过直接分析推断
18453611 GOA
involved in positive regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
11447194 GOA
involved in positive regulation of interleukin-8 production IDA
IDA: 通过直接分析推断
15155775 GOA
involved in positive regulation of leukocyte chemotaxis IDA
IDA: 通过直接分析推断
17991872 GOA
involved in positive regulation of neutrophil mediated killing of gram-negative bacterium IDA
IDA: 通过直接分析推断
21501162 GOA
involved in positive regulation of phagocytosis, engulfment IDA
IDA: 通过直接分析推断
21501162 GOA
involved in positive regulation of positive chemotaxis IDA
IDA: 通过直接分析推断
17991872 GOA
involved in positive regulation of superoxide anion generation IDA
IDA: 通过直接分析推断
11714832 GOA
involved in positive regulation of toll-like receptor 2 signaling pathway IMP
IMP: 通过突变表型推断
19865078 GOA
involved in positive regulation of toll-like receptor 3 signaling pathway IMP
IMP: 通过突变表型推断
19865078 GOA
involved in positive regulation of toll-like receptor 4 signaling pathway IDA
IDA: 通过直接分析推断
18622013 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16410250 GOA
involved in regulation of JNK cascade IDA
IDA: 通过直接分析推断
16410250 GOA
involved in regulation of blood coagulation IDA
IDA: 通过直接分析推断
17848177 GOA
involved in regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
18453611 GOA
involved in regulation of chemokine (C-X-C motif) ligand 2 production IDA
IDA: 通过直接分析推断
21501162 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome IDA
IDA: 通过直接分析推断
22547407 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17848177 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

F2RL1 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (93 - 344)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
蛋白主名 其他名称

proteinase-activated receptor 2

G-protein coupled receptor 11

coagulation factor II (thrombin) receptor-like 1

protease-activated receptor 2

thrombin receptor-like 1

F2RL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
F2RL1 P55085 EPR-1 Homo sapiens Q14868
Anti Bait CoIP
20826780
种属内
F2RL1 P55085 CBL Homo sapiens P22681
Anti Bait CoIP
15708858
种属内
F2RL1 P55085 CBL Homo sapiens P22681
Confocal
15708858
种属内
F2RL1 P55085 COPS5 Homo sapiens Q92905
Y2H
16410250
种属内
F2RL1 P55085 COPS5 Homo sapiens Q92905
Confocal
16410250
种属内
F2RL1 P55085 COPS5 Homo sapiens Q92905
Anti Tag CoIP
16410250
种属内
F2RL1 P55085 COPS5 Homo sapiens Q92905
Pull Down
16410250
种属内
F2RL1 P55085 TMED2 Homo sapiens Q15363
Anti Tag CoIP
17693410
种属内
F2RL1 P55085 TMED2 Homo sapiens Q15363
Y2H
17693410
种属内
F2RL1 P55085 TMED2 Homo sapiens Q15363
Pull Down
17693410
种属间: 跨种属相互作用 种属内: 同种属相互作用

F2RL1 抗体

目录号 产品名 应用 反应物种
HY-P82710 PAR2 Antibody (YA2455) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Pancreatitis

Mumps Pancreatitis
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Alzheimer Disease 12

Ad12

Alzheimer'S Disease 12

Alzheimer Disease, Familial, 12

Alzheimer Disease Familial 12
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Gastroesophageal Reflux

Gastroesophageal Reflux Disease

Gerd

GER

Gastroesophageal Reflux, Pediatric

Acid Reflux

Gastresophageal Reflux

Gastro-Esophageal Reflux

Gerd - Gastro-Esophageal Reflux Disease
Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Granulomatous Orchitis

Non-Specific Granulomatous Orchitis
Vernal Keratoconjunctivitis

Vkc

Spring Catarrh

Keratoconjunctivitis Vernal

Keratoconjunctivitis, Vernal
Neuroleptic Malignant Syndrome
Rhinitis

Runny Nose
Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04634 F2RL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04635 F2rl1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04636 F2rl1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus F2RL1 VGNC VGNC:28684
Canis familiaris F2RL1 VGNC VGNC:40549
Mus musculus F2RL1 MGD MGI:101910
Macaca mulatta F2RL1 VGNC VGNC:110468
Rattus norvegicus F2RL1 RGD RGD:620866
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