TMED2 - transmembrane p24 trafficking protein 2 Gene

中文名称：跨膜 p24 运输蛋白 2

种属: Homo sapiens

同用名: p24; P24A; RNP24; p24b1; p24beta1

基因 ID: 10959 | 基因类型: protein coding

关于 TMED2

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:123,584,552-123,598,582 (from NCBI)

This gene has 5 transcripts (splice variants), 262 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 170.2), colon (RPKM 110.3) and 25 other tissues.

功能概要

参与多个过程，包括高尔基组织； GTP 酶活性的负调节；和蛋白质定位到质膜。位于高尔基体；内质网；和内质网-高尔基中间室。 [由基因组资源联盟提供，2022 年 4 月]

Involved in several processes, including Golgi organization; negative regulation of GTPase activity; and protein localization to plasma membrane. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]

TMED2 基因产物(2)

mRNA	Protein	Name
NM_001321445.2	NP_001308374.1	transmembrane emp24 domain-containing protein 2 isoform 2 precursor
NM_006815.4	NP_006806.1	transmembrane emp24 domain-containing protein 2 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10359607	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Golgi organization	IMP IMP: 通过突变表型推断	17693410	GOA
involved in intracellular protein transport	IDA IDA: 通过直接分析推断	20427317	GOA
involved in negative regulation of GTPase activity	IDA IDA: 通过直接分析推断	10761932	GOA
involved in protein localization to plasma membrane	IDA IDA: 通过直接分析推断	20361938	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	12237308	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	12237308	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: 通过直接分析推断	12237308	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TMED2 蛋白结构

EMP24_GP25L

0
100
201 a.a.

蛋白主名

其他名称

transmembrane emp24 domain-containing protein 2

coated vesicle membrane protein

TMED2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TMED2	Q15363	CD59	Homo sapiens	P13987	Anti Tag CoIP	20427317
种属内	TMED2	Q15363	CD59	Homo sapiens	P13987	Anti Bait CoIP	20427317
种属内	TMED2	Q15363	F2RL1	Homo sapiens	P55085	Confocal	17693410
种属内	TMED2	Q15363	F2RL1	Homo sapiens	P55085	Pull Down	21219331
种属内	TMED2	Q15363	CASR	Homo sapiens	P41180	Anti Tag CoIP	20361938
种属内	TMED2	Q15363	TMED10	Homo sapiens	P49755	Anti Tag CoIP	35271311
种属内	TMED2	Q15363	TMED10	Homo sapiens	P49755	Anti Bait CoIP	18287528
种属内	TMED2	Q15363	TMED10	Homo sapiens	P49755	Anti Bait CoIP	12237308
种属内	TMED2	Q15363	TMED10	Homo sapiens	P49755	Anti Tag CoIP	33961781
种属内	TMED2	Q15363	TMED10	Homo sapiens	P49755	Anti Bait CoIP	16641999

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Epiphyseal Dysplasia, Multiple, 3

EDM3	Multiple Epiphyseal Dysplasia 3
Epiphyseal Dysplasia, Multiple, 3, With Or Without Myopathy	Multiple Epiphyseal Dysplasia 3 With Or Without Myopathy
Epiphyseal Dysplasia Multiple 3	Dysplasia, Epiphyseal, Multiple, Type 3

Cardiomyopathy, Dilated, 1m

Dilated Cardiomyopathy 1m	CMD1M
Cardiomyopathy, Dilated 1m	Cardiomyopathy, Dilated, Type 1m

Cardiomyopathy, Familial Hypertrophic, 7

Hypertrophic Cardiomyopathy 7	CMH7
Cardiomyopathy, Familial Hypertrophic 7	Cardiomyopathy, Hypertrophic, 7
Cardiomyopathy, Hypertrophic, Familial, Type 7

B-Lymphoblastic Leukemia/Lymphoma Mll Rearranged

B-Lymphoblastic Leukemia/Lymphoma Kmt2a Rearranged	B Lymphoblastic Leukemia/Lymphoma With T
Mll Rearranged	B-All Kmt2a Rearranged
B-Lymphoblastic Leukemia/Lymphoma With T	Kmt2a Rearranged

Cardiomyopathy, Dilated, 1p

Dilated Cardiomyopathy 1p	CMD1P
Cardiomyopathy, Dilated 1p	Cardiomyopathy, Dilated, Type 1p

Epiphyseal Dysplasia, Multiple, 1

EDM1	Multiple Epiphyseal Dysplasia 1
Multiple Epiphyseal Dysplasia Type 1	Med1
Multiple Epiphyseal Dysplasia Comp-Related	Polyepiphyseal Dysplasia Type 1
Multiple Epiphyseal Dysplasia, Comp-Related	Epiphyseal Dysplasia Multiple 1
Epiphyseal Dysplasia, Multiple 1	Dysplasia, Epiphyseal, Multiple, Type 1

Epiphyseal Dysplasia, Multiple, 2

EDM2	Multiple Epiphyseal Dysplasia 2
Dysplasia, Epiphyseal, Multiple, Type 2

Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly

Ovarian Mucinous Adenocarcinoma

Mucinous Carcinoma Of Ovary

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14636	TMED2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	TMED2	VGNC	VGNC:80502
Canis familiaris	TMED2	VGNC	VGNC:57417
Rattus norvegicus	TMED2	RGD	RGD:69243
Mus musculus	TMED2	MGD	MGI:1929269

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TMED2 - transmembrane p24 trafficking protein 2 Gene

关于 TMED2

功能概要

TMED2 基因产物(2)

TMED2 蛋白结构

TMED2 蛋白互作信息

关联疾病

直系同源

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TMED2 - transmembrane p24 trafficking protein 2 Gene

关于 TMED2

功能概要

TMED2 基因产物(2)

TMED2 蛋白结构

TMED2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z