COPS6 - COP9 signalosome subunit 6 Gene

中文名称：COP9 信号体亚基 6

种属: Homo sapiens

同用名: CSN6; MOV34-34KD

关于 COPS6

功能概要

该基因编码的蛋白质是 COP9 信号体的八个亚基之一，COP9 信号体是一种高度保守的蛋白质复合物，在多个信号通路中起重要调节作用。 COP9 信号体的结构和功能类似于 26S 蛋白酶体的 19S 调节颗粒。 COP9 信号体已被证明与 SCF 型 E3 泛素连接酶相互作用，并作为 E3 泛素连接酶的正调节剂。该蛋白属于翻译起始因子 3 (eIF3) 超家族。它参与细胞周期的调节，可能是 HIV-1 辅助基因产物 Vpr 的细胞辅助因子。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S Proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]