2. Gene
  3. COPS3 - COP9 signalosome subunit 3 Gene

COPS3 - COP9 signalosome subunit 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：COP9 信号体亚基 3

种属: Homo sapiens

同用名: CSN3; SGN3

基因 ID: 8533 | 基因类型: protein coding

关于 COPS3

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:17,246,616-17,281,246 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 49.1), bone marrow (RPKM 38.5) and 25 other tissues.

功能概要

由该基因编码的蛋白质具有磷酸化参与信号转导的调节因子的激酶活性。它磷酸化 I kappa-Balpha、p105 和 c-Jun。它充当复合物介导的磷酸化的停靠位点。该基因位于 17 号染色体上的 Smith-Magenis 综合征区域内。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2015 年 10 月]

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

COPS3 基因产物(7)

mRNA Protein Name
NM_001199125.1 NP_001186054.1 COP9 signalosome complex subunit 3 isoform 2
NM_001316354.2 NP_001303283.1 COP9 signalosome complex subunit 3 isoform 3
NM_001316355.2 NP_001303284.1 COP9 signalosome complex subunit 3 isoform 4
NM_001316356.2 NP_001303285.1 COP9 signalosome complex subunit 3 isoform 5
NM_001316357.2 NP_001303286.1 COP9 signalosome complex subunit 3 isoform 6
NM_001316358.2 NP_001303287.1 COP9 signalosome complex subunit 3 isoform 6
NM_003653.4 NP_003644.2 COP9 signalosome complex subunit 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10777491 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein deneddylation IDA
IDA: 通过直接分析推断
19141280 GOA
involved in regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
IMP: 通过突变表型推断
15861129 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of COP9 signalosome IDA
IDA: 通过直接分析推断
18850735 GOA
part of COP9 signalosome IPI
IPI: 通过物理相互作用推断
25043011 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
24421388 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24421388 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
15861129 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

COPS3 蛋白结构

PCI

PCI: PCI domain (259 - 361)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
蛋白主名 其他名称

COP9 signalosome complex subunit 3

COP9 complex subunit 3

COPS3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
COPS3 Q9UNS2 NF2 Homo sapiens P35240
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 NF2 Homo sapiens P35240
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 NF2 Homo sapiens P35240
Y2H Array
32814053
种属内
COPS3 Q9UNS2 YARS1 Homo sapiens P54577
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 YARS1 Homo sapiens P54577
Y2H Array
32814053
种属内
COPS3 Q9UNS2 YARS1 Homo sapiens P54577
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 COPS2 Homo sapiens P61201
Pull Down
25043011
种属内
COPS3 Q9UNS2 COPS2 Homo sapiens P61201
Anti Tag CoIP
24421388
种属内
COPS3 Q9UNS2 COPS2 Homo sapiens P61201
Anti Bait CoIP
24421388
种属内
COPS3 Q9UNS2 COPS2 Homo sapiens P61201
Pull Down
20399188
种属内
COPS3 Q9UNS2 COPS2 Homo sapiens P61201
Anti Tag CoIP
33961781
种属内
COPS3 Q9UNS2 RAB7A Homo sapiens P51149
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 RAB7A Homo sapiens P51149
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 RAB7A Homo sapiens P51149
Y2H Array
32814053
种属内
COPS3 Q9UNS2 MECP2 Homo sapiens P51608
Y2H Array
32814053
种属内
COPS3 Q9UNS2 MECP2 Homo sapiens P51608
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 MECP2 Homo sapiens P51608
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 ERCC8 Homo sapiens Q13216-2
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 ERCC8 Homo sapiens Q13216-2
Y2H Array
32814053
种属内
COPS3 Q9UNS2 ERCC8 Homo sapiens Q13216-2
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 GLE1 Homo sapiens Q53GS7
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 GLE1 Homo sapiens Q53GS7
Y2H Array
32814053
种属内
COPS3 Q9UNS2 GLE1 Homo sapiens Q53GS7
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 COPS8 Homo sapiens Q99627
Pull Down
25043011
种属内
COPS3 Q9UNS2 COPS8 Homo sapiens Q99627
Pull Down
20399188
种属内
COPS3 Q9UNS2 DCTN1 Homo sapiens Q14203-5
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 DCTN1 Homo sapiens Q14203-5
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 DCTN1 Homo sapiens Q14203-5
Y2H Array
32814053
种属内
COPS3 Q9UNS2 PANK2 Homo sapiens Q9BZ23-2
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 PANK2 Homo sapiens Q9BZ23-2
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 PANK2 Homo sapiens Q9BZ23-2
Y2H Array
32814053
种属内
COPS3 Q9UNS2 TTBK2 Homo sapiens Q6IQ55-3
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 TTBK2 Homo sapiens Q6IQ55-3
Y2H Array
32814053
种属内
COPS3 Q9UNS2 TTBK2 Homo sapiens Q6IQ55-3
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 SOS1 Homo sapiens Q07889
Y2H
30631038
种属内
COPS3 Q9UNS2 SOS1 Homo sapiens Q07889
Pull Down
30631038
种属内
COPS3 Q9UNS2 DDB1 Homo sapiens Q16531
Anti Tag CoIP
33961781
种属内
COPS3 Q9UNS2 DDB1 Homo sapiens Q16531
Y2H
10777491
种属内
COPS3 Q9UNS2 LMNA Homo sapiens P02545-2
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 LMNA Homo sapiens P02545-2
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 LMNA Homo sapiens P02545-2
Y2H Array
32814053
种属内
COPS3 Q9UNS2 HSPB1 Homo sapiens P04792
Y2H Array
32814053
种属内
COPS3 Q9UNS2 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 CCT5 Homo sapiens P48643
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 CCT5 Homo sapiens P48643
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 CCT5 Homo sapiens P48643
Y2H Array
32814053
种属内
COPS3 Q9UNS2 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
种属内
COPS3 Q9UNS2 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 COPS6 Homo sapiens Q7L5N1
Anti Tag CoIP
24421388
种属内
COPS3 Q9UNS2 COPS6 Homo sapiens Q7L5N1
Anti Tag CoIP
33961781
种属内
COPS3 Q9UNS2 COPS6 Homo sapiens Q7L5N1
Pull Down
25043011
种属内
COPS3 Q9UNS2 COPS6 Homo sapiens Q7L5N1
Anti Bait CoIP
24421388
种属内
COPS3 Q9UNS2 COPS6 Homo sapiens Q7L5N1
Pull Down
20399188
种属内
COPS3 Q9UNS2 TOR1A Homo sapiens O14656
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 TOR1A Homo sapiens O14656
Y2H Array
32814053
种属内
COPS3 Q9UNS2 TOR1A Homo sapiens O14656
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 COPS5 Homo sapiens Q92905
Pull Down
25043011
种属内
COPS3 Q9UNS2 COPS5 Homo sapiens Q92905
Anti Tag CoIP
24421388
种属内
COPS3 Q9UNS2 COPS5 Homo sapiens Q92905
Anti Bait CoIP
24421388
种属内
COPS3 Q9UNS2 COPS5 Homo sapiens Q92905
Pull Down
20399188
种属内
COPS3 Q9UNS2 COPS5 Homo sapiens Q92905
Anti Tag CoIP
33961781
种属内
COPS3 Q9UNS2 A2M Homo sapiens P01023
Y2H Array
32814053
种属内
COPS3 Q9UNS2 A2M Homo sapiens P01023
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 A2M Homo sapiens P01023
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 ATXN10 Homo sapiens Q9UBB4
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 ATXN10 Homo sapiens Q9UBB4
Y2H Array
32814053
种属内
COPS3 Q9UNS2 ATXN10 Homo sapiens Q9UBB4
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 TTR Homo sapiens P02766
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 TTR Homo sapiens P02766
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 TTR Homo sapiens P02766
Y2H Array
32814053
种属内
COPS3 Q9UNS2 COPS7A Homo sapiens Q9UBW8
Anti Bait CoIP
24421388
种属内
COPS3 Q9UNS2 COPS7A Homo sapiens Q9UBW8
Pull Down
20399188
种属内
COPS3 Q9UNS2 COPS7A Homo sapiens Q9UBW8
Anti Tag CoIP
28514442
种属内
COPS3 Q9UNS2 COPS7A Homo sapiens Q9UBW8
Anti Tag CoIP
33961781
种属内
COPS3 Q9UNS2 COPS7A Homo sapiens Q9UBW8
Pull Down
25043011
种属内
COPS3 Q9UNS2 HEXB Homo sapiens P07686
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 HEXB Homo sapiens P07686
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 HEXB Homo sapiens P07686
Y2H Array
32814053
种属内
COPS3 Q9UNS2 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
种属内
COPS3 Q9UNS2 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 UCHL1 Homo sapiens P09936
Y2H Array
32814053
种属内
COPS3 Q9UNS2 UCHL1 Homo sapiens P09936
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 UCHL1 Homo sapiens P09936
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 PHYH Homo sapiens O14832
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 PHYH Homo sapiens O14832
Y2H Array
32814053
种属内
COPS3 Q9UNS2 PHYH Homo sapiens O14832
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 PHYH Homo sapiens O14832
Anti Bait CoIP
17353931
种属内
COPS3 Q9UNS2 GARS1 Homo sapiens P41250
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 GARS1 Homo sapiens P41250
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 GARS1 Homo sapiens P41250
Y2H Array
32814053
种属内
COPS3 Q9UNS2 SNCB Homo sapiens Q16143
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 SNCB Homo sapiens Q16143
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 SNCB Homo sapiens Q16143
Y2H Array
32814053
种属内
COPS3 Q9UNS2 ASPA Homo sapiens P45381
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 ASPA Homo sapiens P45381
Y2H Array
32814053
种属内
COPS3 Q9UNS2 ASPA Homo sapiens P45381
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 PRPH Homo sapiens P41219
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 PRPH Homo sapiens P41219
Y2H Array
32814053
种属内
COPS3 Q9UNS2 PRPH Homo sapiens P41219
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 DBH Homo sapiens P09172
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 DBH Homo sapiens P09172
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 DBH Homo sapiens P09172
Y2H Array
32814053
种属内
COPS3 Q9UNS2 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
种属内
COPS3 Q9UNS2 PEX1 Homo sapiens O43933
Validated Y2H
32814053
种属内
COPS3 Q9UNS2 PEX1 Homo sapiens O43933
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

COPS3 抗体

目录号 产品名 应用 反应物种
HY-P82446 COPS3 Antibody (YA2191) WB, ICC/IF, IP, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Smith-Magenis Syndrome

SMS

Chromosome 17p11.2 Deletion Syndrome

17p11.2 Microdeletion Syndrome

17p11.2 Monosomy

Chromosome 17p Deletion Syndrome

Del(17)

P11.2

17p- Syndrome

Deletion 17p Syndrome

Partial Monosomy 17p
Bone Angioendothelial Sarcoma

Osseous Hemangiosarcoma

Bone Angiosarcoma
Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V

Xp5

Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype

Xpe

Xp, Group E

Xeroderma Pigmentosum, Type 5

Xeroderma Pigmentosum Complementation Group E

XP-E

Xp Group E
Parosteal Osteosarcoma

Juxtacortical Osteosarcoma

Parosteal Osteogenic Sarcoma

Osteosarcoma, Juxtacortical
Peripheral Osteosarcoma

Surface Osteosarcoma

Bone Surface Osteosarcoma
Telangiectatic Osteogenic Sarcoma

Telangiectatic Osteosarcoma
Conventional Osteosarcoma

Intracortical Osteosarcoma

Conventional Central Osteosarcoma

Intracortical Osteogenic Sarcoma

Medullary Osteosarcoma
Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone
Potocki-Lupski Syndrome

PTLS

Chromosome 17p11.2 Duplication Syndrome

17p11.2 Microduplication Syndrome

Duplication 17p11.2 Syndrome

Trisomy 17p11.2

Potocki-Lupski Syndrome (Dup(17)(P11.2p11.2))

17p11.2 Duplication Syndrome

Dup(17)(P11.2p11.2)

Pls

Chromosome 17, Trisomy 17p11 2
Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03028 COPS3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus COPS3 VGNC VGNC:61088
Rattus norvegicus COPS3 RGD RGD:1303002
Macaca mulatta COPS3 VGNC VGNC:71316
Mus musculus COPS3 MGD MGI:1349409
Canis familiaris COPS3 VGNC VGNC:39510
Bos taurus COPS3 VGNC VGNC:27600
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