COPS8 - COP9 signalosome subunit 8 Gene

中文名称：COP9 信号体亚基 8

种属: Homo sapiens

同用名: COP9; CSN8; SGN8

基因 ID: 10920 | 基因类型: protein coding

关于 COPS8

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:237,085,889-237,100,474 (from NCBI)

This gene has 7 transcripts (splice variants) and 141 orthologues. Ubiquitous expression in brain (RPKM 28.1), testis (RPKM 22.3) and 25 other tissues.

功能概要

该基因编码的蛋白质是 COP9 信号体的八个亚基之一，COP9 信号体是一种高度保守的蛋白质复合物，在多个信号通路中起重要调节作用。 COP9 信号体的结构和功能类似于 26S 蛋白酶体的 19S 调节颗粒。 COP9 信号体已被证明与 SCF 型 E3 泛素连接酶相互作用，并作为 E3 泛素连接酶的正调节剂。已经观察到编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S Proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

COPS8 基因产物(2)

mRNA	Protein	Name
NM_006710.5	NP_006701.1	COP9 signalosome complex subunit 8 isoform 1
NM_198189.3	NP_937832.1	COP9 signalosome complex subunit 8 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	20399188	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of NF-kappaB-inducing kinase activity	IMP IMP: 通过突变表型推断	22992343	GOA
involved in negative regulation of cell population proliferation	IMP IMP: 通过突变表型推断	23689509	GOA
involved in protein deneddylation	IDA IDA: 通过直接分析推断	19141280	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	9535219	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of COP9 signalosome	IDA IDA: 通过直接分析推断	9535219	GOA
part of COP9 signalosome	IPI IPI: 通过物理相互作用推断	25043011	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	24421388	GOA
located in nucleus	IDA IDA: 通过直接分析推断	24421388	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	9535219	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

COPS8 蛋白结构

CSN8_PSD8_EIF3K

0
100
209 a.a.

蛋白主名

其他名称

COP9 signalosome complex subunit 8

COP9 constitutive photomorphogenic homolog subunit 8

COPS8 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	COPS8	Q99627	GPS1	Homo sapiens	Q13098-7	Pull Down	25043011
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	Complementation	32296183
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	TAP	27173435
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	Pull Down	25043011
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	Y2H Array	32296183
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	MAPPIT	32296183
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	33961781
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	28514442
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	Y2H Prey Pooling	32296183
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	Validated Y2H	32296183
Intra	COPS8	Q99627	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956
Intra	COPS8	Q99627	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V	Xp5
Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype	Xpe
Xp, Group E	Xeroderma Pigmentosum, Type 5
Xeroderma Pigmentosum Complementation Group E	XP-E
Xp Group E

Smith-Magenis Syndrome

SMS	Chromosome 17p11.2 Deletion Syndrome
17p11.2 Microdeletion Syndrome	17p11.2 Monosomy
Chromosome 17p Deletion Syndrome	Del(17)
P11.2	17p- Syndrome
Deletion 17p Syndrome	Partial Monosomy 17p

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03032	COPS8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	COPS8	VGNC	VGNC:71334
Mus musculus	COPS8	MGD	MGI:1915363
Felis catus	COPS8	VGNC	VGNC:61092
Bos taurus	COPS8	VGNC	VGNC:27606
Rattus norvegicus	COPS8	RGD	RGD:1311404

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

COPS8 - COP9 signalosome subunit 8 Gene

关于 COPS8

功能概要

COPS8 基因产物(2)

COPS8 蛋白结构

COPS8 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

COPS8 - COP9 signalosome subunit 8 Gene

关于 COPS8

功能概要

COPS8 基因产物(2)

COPS8 蛋白结构

COPS8 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z