1. Gene
  2. COPS4 - COP9 signalosome subunit 4 Gene

COPS4 - COP9 signalosome subunit 4 Gene

中文名称:COP9 信号体亚基 4

种属: Homo sapiens

同用名: CSN4; SGN4

基因 ID: 51138 | 基因类型: protein coding

关于 COPS4

Cytogenetic location: 4q21.22 Genomic coordinates (GRCh38): 4:83,035,183-83,075,818 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 26.4), brain (RPKM 21.8) and 25 other tissues.

功能概要

该基因编码构成 COP9 信号体的八个亚基之一,COP9 信号体是一种高度保守的蛋白质复合物,在多个信号通路中起重要调节作用。 COP9 信号体的结构和功能类似于 26S 蛋白酶体的 19S 调节颗粒。 COP9 信号体已被证明与 SCF 型 E3 泛素连接酶相互作用,并作为 E3 泛素连接酶的正调节剂。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供,2012 年 4 月]

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S Proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

COPS4 基因产物(3)

mRNA Protein Name
NM_001258006.2 NP_001244935.1 COP9 signalosome complex subunit 4 isoform 2
NM_001330727.2 NP_001317656.1 COP9 signalosome complex subunit 4 isoform 3
NM_016129.3 NP_057213.2 COP9 signalosome complex subunit 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein deneddylation IDA
IDA: 通过直接分析推断
19141280 GOA
involved in protein deneddylation IMP
IMP: 通过突变表型推断
21102408 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of COP9 signalosome IDA
IDA: 通过直接分析推断
18850735 GOA
part of COP9 signalosome IPI
IPI: 通过物理相互作用推断
25043011 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
24421388 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24421388 GOA
located in synaptic vesicle IDA
IDA: 通过直接分析推断
21102408 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

COPS4 蛋白结构

PCI

PCI: PCI domain (268 - 362)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
蛋白主名 其他名称

COP9 signalosome complex subunit 4

COP9 constitutive photomorphogenic homolog subunit 4

COPS4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra COPS4 Q9BT78 PCDHB12 Homo sapiens Q9Y5F1
Validated Y2H
32296183
Intra COPS4 Q9BT78 STK11 Homo sapiens Q15831
Anti Tag CoIP
25852190
Intra COPS4 Q9BT78 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
26871637
Intra COPS4 Q9BT78 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Intra COPS4 Q9BT78 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
26871637
Intra COPS4 Q9BT78 USHBP1 Homo sapiens Q8N6Y0
Y2H Pooling
16189514
Intra COPS4 Q9BT78 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
26871637
Intra COPS4 Q9BT78 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Intra COPS4 Q9BT78 BRME1 Homo sapiens Q0VDD7
Y2H Pooling
16189514
Intra COPS4 Q9BT78 BRME1 Homo sapiens Q0VDD7
Pull Down
16189514
Intra COPS4 Q9BT78 KRT19 Homo sapiens P08727
Validated Y2H
26871637
Intra COPS4 Q9BT78 KRT19 Homo sapiens P08727
Y2H Array
26871637
Intra COPS4 Q9BT78 KRT19 Homo sapiens P08727
Y2H Prey Pooling
26871637
Intra COPS4 Q9BT78 FOS Homo sapiens P01100
Display Tech
20195357
Intra COPS4 Q9BT78 FOS Homo sapiens P01100
TAP
20195357
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V

Xp5

Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype

Xpe

Xp, Group E

Xeroderma Pigmentosum, Type 5

Xeroderma Pigmentosum Complementation Group E

XP-E

Xp Group E

Sulfonamide Allergy
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus COPS4 RGD RGD:1302952
Canis familiaris COPS4 VGNC VGNC:39511
Felis catus COPS4 VGNC VGNC:61089
Bos taurus COPS4 VGNC VGNC:27601
Macaca mulatta COPS4 VGNC VGNC:71183
Mus musculus COPS4 MGD MGI:1349414