2. Gene
  3. GPS1 - G protein pathway suppressor 1 Gene

GPS1 - G protein pathway suppressor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白通路抑制因子 1

种属: Homo sapiens

同用名: CSN1; SGN1; COPS1

基因 ID: 2873 | 基因类型: protein coding

关于 GPS1

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,050,932-82,057,470 (from NCBI)

This gene has 28 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 28.1), testis (RPKM 27.1) and 25 other tissues.

功能概要

已知该基因可抑制哺乳动物细胞中的 G 蛋白和丝裂原激活信号转导。编码的蛋白质与拟南芥 FUS6 具有显着相似性，拟南芥 FUS6 是植物细胞中光介导信号转导的调节剂。[RefSeq 提供，2016 年 3 月]

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]

GPS1 基因产物(28)

mRNA Protein Name
NM_001321089.3 NP_001308018.1 COP9 signalosome complex subunit 1 isoform 3
NM_001321090.3 NP_001308019.1 COP9 signalosome complex subunit 1 isoform 4
NM_001321091.3 NP_001308020.1 COP9 signalosome complex subunit 1 isoform 5
NM_001321092.3 NP_001308021.1 COP9 signalosome complex subunit 1 isoform 6
NM_001321093.3 NP_001308022.1 COP9 signalosome complex subunit 1 isoform 7
NM_001330539.3 NP_001317468.1 COP9 signalosome complex subunit 1 isoform 8
NM_001330541.3 NP_001317470.1 COP9 signalosome complex subunit 1 isoform 9
NM_001394759.1 NP_001381688.1 COP9 signalosome complex subunit 1 isoform 10
NM_001394760.1 NP_001381689.1 COP9 signalosome complex subunit 1 isoform 11
NM_001394761.1 NP_001381690.1 COP9 signalosome complex subunit 1 isoform 12
NM_001394762.1 NP_001381691.1 COP9 signalosome complex subunit 1 isoform 13
NM_001394763.1 NP_001381692.1 COP9 signalosome complex subunit 1 isoform 13
NM_001394764.1 NP_001381693.1 COP9 signalosome complex subunit 1 isoform 14
NM_001394765.1 NP_001381694.1 COP9 signalosome complex subunit 1 isoform 15
NM_001394766.1 NP_001381695.1 COP9 signalosome complex subunit 1 isoform 15
NM_001394767.1 NP_001381696.1 COP9 signalosome complex subunit 1 isoform 15
NM_001394768.1 NP_001381697.1 COP9 signalosome complex subunit 1 isoform 16
NM_001394769.1 NP_001381698.1 COP9 signalosome complex subunit 1 isoform 7
NM_001394770.1 NP_001381699.1 COP9 signalosome complex subunit 1 isoform 7
NM_001394771.1 NP_001381700.1 COP9 signalosome complex subunit 1 isoform 7
NM_001394772.1 NP_001381701.1 COP9 signalosome complex subunit 1 isoform 17
NM_001394773.1 NP_001381702.1 COP9 signalosome complex subunit 1 isoform 17
NM_001394774.1 NP_001381703.1 COP9 signalosome complex subunit 1 isoform 18
NM_001394775.1 NP_001381704.1 COP9 signalosome complex subunit 1 isoform 19
NM_001394776.1 NP_001381705.1 COP9 signalosome complex subunit 1 isoform 20
NM_001394777.1 NP_001381706.1 COP9 signalosome complex subunit 1 isoform 21
NM_004127.7 NP_004118.3 COP9 signalosome complex subunit 1 isoform 2
NM_212492.4 NP_997657.1 COP9 signalosome complex subunit 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17337451 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein deneddylation IDA
IDA: 通过直接分析推断
19141280 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of COP9 signalosome IDA
IDA: 通过直接分析推断
18850735 GOA
part of COP9 signalosome IPI
IPI: 通过物理相互作用推断
25043011 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
24421388 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24421388 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPS1 蛋白结构

RPN7

RPN7: 26S proteasome subunit RPN7 (127 - 308)

PCI

PCI: PCI domain (324 - 426)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 491 a.a.
蛋白主名 其他名称

COP9 signalosome complex subunit 1

JAB1-containing signalosome subunit 1

GPS1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GPS1 Q13098 COPS5 Homo sapiens Q92905
TEM
27029275
种属内
GPS1 Q13098 COPS5 Homo sapiens Q92905
Anti Tag CoIP
33961781
种属内
GPS1 Q13098 COPS5 Homo sapiens Q92905
EM
20399188
种属内
GPS1 Q13098 COPS5 Homo sapiens Q92905
GMS
20399188
种属内
GPS1 Q13098 COPS5 Homo sapiens Q92905
Anti Bait CoIP
19444310
种属内
GPS1 Q13098 COPS5 Homo sapiens Q92905
3D-EM
27029275
种属内
GPS1 Q13098 COPS5 Homo sapiens Q92905
X-Ray Diffraction
27029275
种属内
GPS1 Q13098 COPS5 Homo sapiens Q92905
Solution Sedimentation
24421388
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V

Xp5

Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype

Xpe

Xp, Group E

Xeroderma Pigmentosum, Type 5

Xeroderma Pigmentosum Complementation Group E

XP-E

Xp Group E
Corneal Dystrophy, Avellino Type

Avellino Corneal Dystrophy

CDA

Combined Granular-Lattice Corneal Dystrophy

Cgd2

Granular Corneal Dystrophy Type 2

Acd

Granular Corneal Dystrophy 2

Corneal Dystrophy Avellino Type

Granular Corneal Dystrophy Type Ii

Granular Corneal Dystrophy, Type Ii

Combined Granular-Lattice Corneal Dystrophies

Granular And Lattice Corneal Dystrophies

Granular-Lattice Corneal Dystrophy

Gcd2

Gcdii

Granular-Lattice Corneal Dystrophy
Granular Corneal Dystrophy

Granular Dystrophy Corneal

Corneal Dystrophies, Hereditary

Hereditary Corneal Dystrophy

Corneal Dystrophy Nos

Familial Hereditary Corneal Degeneration

Hereditary Corneal Opacity
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05757 GPS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GPS1 RGD RGD:621532
Macaca mulatta GPS1 VGNC VGNC:73149
Mus musculus GPS1 MGD MGI:2384801
Canis familiaris GPS1 VGNC VGNC:41455
Felis catus GPS1 VGNC VGNC:67450
Bos taurus GPS1 VGNC VGNC:29612
Others GPS1 NCBI
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