2. Gene
  3. RNF20 - ring finger protein 20 Gene

RNF20 - ring finger protein 20 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：无名指蛋白 20

种属: Homo sapiens

同用名: BRE1; BRE1A; hBRE1

基因 ID: 56254 | 基因类型: protein coding

关于 RNF20

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:101,533,853-101,563,344 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 16.7), brain (RPKM 13.7) and 25 other tissues.

功能概要

该基因编码的蛋白质与酿酒酵母的 BRE1 具有相似性。由该人类基因编码的蛋白质是一种 E3 泛素连接酶，它通过单泛素化组蛋白 H2B 来调节染色体结构。这种蛋白质充当推定的肿瘤抑制因子并正向调节 p53 肿瘤抑制因子以及许多组蛋白 H2A 和 H2B 基因。相反，这种蛋白质还抑制了几种原癌基因和生长相关基因的表达，包括许多由表皮生长因子诱导的基因。该基因通过干扰转录延伸因子 SII (TFIIS) 的染色质募集，选择性地抑制某些基因的表达。[RefSeq 提供，2012 年 2 月]

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin Ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]

RNF20 基因产物(1)

mRNA Protein Name
NM_019592.7 NP_062538.5 E3 ubiquitin-protein ligase BRE1A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone H2B C-terminal K residue ubiquitin ligase activity IMP
IMP: 通过突变表型推断
16337599 GOA
enables histone binding IDA
IDA: 通过直接分析推断
16337599 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables mRNA 3'-UTR binding IDA
IDA: 通过直接分析推断
19575011 GOA
enables p53 binding IDA
IDA: 通过直接分析推断
16337599 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16307923 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
16337599 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
16307923 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
16307923 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
19037095 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cell migration IDA
IDA: 通过直接分析推断
18832071 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
16713563 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16307923 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
19037095 GOA
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
18832071 GOA
NOT involved in regulation of mitotic cell cycle IMP
IMP: 通过突变表型推断
19575011 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
19037095 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of HULC complex IDA
IDA: 通过直接分析推断
19410543 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
19037095 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16307923 GOA
part of ubiquitin ligase complex IDA
IDA: 通过直接分析推断
16307923 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNF20 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (922 - 960)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 975 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase BRE1A

BRE1 E3 ubiquitin ligase homolog

RNF20 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RNF20 Q5VTR2 AMOTL2 Homo sapiens Q9Y2J4-4
Y2H Array
25416956
Intra RNF20 Q5VTR2 CHEK2 Homo sapiens O96017
Anti Tag CoIP
25640309
Intra RNF20 Q5VTR2 RNF40 Homo sapiens O75150
Anti Tag CoIP
19410543
Intra RNF20 Q5VTR2 RNF40 Homo sapiens O75150
Chromatography
19410543
Intra RNF20 Q5VTR2 RNF40 Homo sapiens O75150
GMS
16307923
Intra RNF20 Q5VTR2 TACC3 Homo sapiens Q9Y6A5
Y2H Prey Pooling
32296183
Intra RNF20 Q5VTR2 TACC3 Homo sapiens Q9Y6A5
Validated Y2H
32296183
Intra RNF20 Q5VTR2 TACC3 Homo sapiens Q9Y6A5
Y2H Array
32296183
Intra RNF20 Q5VTR2 UBE2E1 Homo sapiens P51965
Pull Down
16307923
Intra RNF20 Q5VTR2 HTT Homo sapiens P42858
Y2H Prey Pooling
23275563
Intra RNF20 Q5VTR2 HTT Homo sapiens P42858
Y2H
17500595
Intra RNF20 Q5VTR2 COPS5 Homo sapiens Q92905
Biochemical
19214193
Intra RNF20 Q5VTR2 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Intra RNF20 Q5VTR2 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
25416956
Intra RNF20 Q5VTR2 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
Intra RNF20 Q5VTR2 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
Intra RNF20 Q5VTR2 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
Intra RNF20 Q5VTR2 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra RNF20 Q5VTR2 CDC73 Homo sapiens Q6P1J9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis

Testicular Germ Cell Tumor

Testicular Germ Cell Neoplasm

Testicular Malignant Germ Cell Tumor
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12075 RNF20 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RNF20 VGNC VGNC:76704
Felis catus RNF20 VGNC VGNC:64689
Canis familiaris RNF20 VGNC VGNC:45653
Mus musculus RNF20 MGD MGI:1925927
Rattus norvegicus RNF20 RGD RGD:1311936
Bos taurus RNF20 VGNC VGNC:34047
Others RNF20 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z