RNF40 - ring finger protein 40 Gene

中文名称：无名指蛋白 40

种属: Homo sapiens

同用名: BRE1B; RBP95; STARING

关于 RNF40

功能概要

由该基因编码的蛋白质包含一个无名指，这是一种已知参与蛋白质-蛋白质和蛋白质-DNA 相互作用的基序。据报道，该蛋白质与肿瘤抑制蛋白 RB1 相互作用。对大鼠对应物的研究表明，这种蛋白质可能作为 E3 泛素蛋白连接酶发挥作用，并促进突触融合蛋白 1 的泛素化和降解，突触融合蛋白 1 是神经递质释放机制的重要组成部分。已为该基因发现编码不同亚型的多个可变剪接转录物变体。[RefSeq 提供，2011 年 5 月]

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein Ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]